Article(id=1291707032286023916, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.22.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747238400000, receivedDateStr=2025-05-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896555252, onlineDateStr=2026-08-05, pubDate=1764259200000, pubDateStr=2025-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896555252, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896555252, creator=13701087609, updateTime=1785896555252, updator=13701087609, issue=Issue{id=1291707004800750583, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='22', pageStart='3151', pageEnd='3300', issueExtLink='null', onlineDate='null', pubDate='1764259200000', pubDateStr='2025-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896548700, creator='13701087609', updateTime=1785896693213, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707610999316815, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707610999316816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291707004800750583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3185, endPage=3190, ext={EN=ArticleExt(id=1291707032550265069, articleId=1291707032286023916, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of conbercept in elderly patients with diabetic retinopathy, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effect of conbercept ophthalmic injection on aqueous humor glucose (AHG) and vascular endothelial growth factor (VEGF) in elderly patients with diabetes retinopathy (DR) and vitreous hemorrhage, and the correlation with blood glucose.
Methods A total of 80 elderly patients with DR and vitreous hemorrhage were selected as the study subjects. All of them received intravitreal injection of 0.05 mL of conbercept ophthalmic injection for 7 consecutive days, and then underwent vitrectomy. They were divided into the standard reaching group and the non-standard reaching group according to whether blood glucose control met the standard. The changes in ocular signs and visual recovery indicators [central macular thickness (CMT), hemorrhagic spot area and best corrected visual acuity (BCVA)], aqueous humor AHG, VEGF, inflammatory factors [interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)] and blood glucose before and after conbercept ophthalmic injection treatment were compared between groups. Pearson method was used to analyze the correlation between AHG, VEGF and blood glucose level. Logistic regression method was used to identify the independent influencing factors of inadequate blood glucose control.
Results 49 patients were included in the standard reaching group, and 31 patients were included in the non-standard reaching group. After treatment, the CMT values of standard reaching and the non-standard reaching groups were (215.63±22.45) and (254.68±26.73) μm, respectively; the bleeding spot areas were (1.18±0.14) and (1.46±0.17) mm2, respectively; the BCVA values were 0.85±0.07 and 0.71±0.08, respectively; the AHG values for aqueous humor were (4.68±0.54) and (6.27±0.65) mmol·L-1, respectively; VEGF levels were (121.46±13.65) and (158.72±16.39) pg·mL-1, respectively; IL-6 levels were (18.13±1.89) and (19.44±2.31) pg·mL-1, respectively; TNF-α levels were (6.73±0.75) and (7.16±0.73) pg·mL-1, respectively; the blood glucose levels were (5.16±0.57) and (7.22±0.78) mmol·L-1, respectively; the above indicators of standard reaching group were compared with those of the non-standard reaching group, and the differences were statistically significant (all P<0.05). Correlation analysis found that the levels of aqueous humor AHG, VEGF, IL-6 and TNF-α were positively correlated with blood glucose levels in elderly patients with DR and vitreous hemorrhage (P<0.05). Logistic regression analysis showed that aqueous humor AHG, VEGF, and IL-6 were independent risk factors for inadequate blood glucose control in elderly patients with DR and vitreous hemorrhage (P<0.05).
Conclusion After conbercept ophthalmic injection treatment, there are significant differences in the levels of AHG and VEGF in elderly patients with DR and vitreous hemorrhage, and visual acuity is restored. Moreover, AHG and VEGF are positively correlated with blood glucose. Monitoring them can assist in efficacy evaluation.
, authors=Wen-zhang LIANG
1, Jing-he HUANG
1, Yan-fang WANG
2, authorsList=Wen-zhang LIANG, Jing-he HUANG, Yan-fang WANG, authorCompany=null, correspAuthors=Jing-he HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707032848060654, articleId=1291707032286023916, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=康柏西普对老年糖尿病视网膜病变伴玻璃体积血患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 分析康柏西普眼用注射液对老年糖尿病视网膜病变（DR）伴玻璃体积血患者房水葡萄糖（AHG）、血管内皮生长因子（VEGF）的影响及与血糖的相关性。
方法 选取老年DR伴玻璃体积血患者80例为研究对象，均经玻璃体腔注射康柏西普眼用注射液0.05 mL，连续7 d后均行玻璃体切割手术治疗，以血糖控制是否达标分为达标组和未达标组，对比2组采用康柏西普眼用注射液治疗前后眼部体征与视力恢复指标[中心凹视网膜厚度（CMT）、出血斑面积、最佳矫正视力（BCVA）]、房水AHG、VEGF、炎性因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]、血糖变化，并采用Pearson法分析患者AHG、VEGF与其血糖水平相关性，经Logistics回归法分析血糖控制不达标的独立影响因素。
结果 达标组纳入49例、未达标组纳入31例。治疗后，达标组和未达标组的CMT分别为（215.63±22.45）和（254.68±26.73）μm；出血斑面积分别为（1.18±0.14）和（1.46±0.17）mm2；BCVA分别为0.85±0.07和0.71±0.08；房水AHG分别为（4.68±0.54）和（6.27±0.65）mmol·L-1；VEGF分别为（121.46±13.65）和（158.72±16.39）pg·mL-1；IL-6分别为（18.13±1.89）和（19.44±2.31）pg·mL-1；TNF-α分别为（6.73±0.75）和（7.16±0.73）pg·mL-1；血糖水平分别为（5.16±0.57）和（7.22±0.78）mmol·L-1，达标组上述指标与未达标组比较，在统计学上差异均有统计学意义（均P<0.05）。相关分析发现，老年DR伴玻璃体积血患者房水AHG、VEGF、IL-6、TNF-α与血糖水平呈正相关，在统计学上差异均有统计学意义（均P<0.05）；Logistics回归分析显示，房水AHG、VEGF、IL-6为老年DR伴玻璃体积血患者血糖控制不达标的独立危险因素，在统计学上差异均具有统计学意义（均P<0.05）。
结论 老年DR伴玻璃体积血患者经康柏西普眼用注射液治疗后AHG、VEGF水平明显下降，视力得以恢复，且AHG、VEGF和血糖存在正相关关系，对其予以监测可用于判断疗效。
, authors=梁文章
1, 黄经河
1, 汪艳芳
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梁文章（1982-），男，副主任医师，主要从事眼表、玻璃体视网膜方向的临床工作和研究
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