Article(id=1291707022140011482, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.21.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752595200000, receivedDateStr=2025-07-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896552834, onlineDateStr=2026-08-05, pubDate=1763308800000, pubDateStr=2025-11-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896552834, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896552834, creator=13701087609, updateTime=1785896552834, updator=13701087609, issue=Issue{id=1291706987964822180, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='21', pageStart='3001', pageEnd='3150', issueExtLink='null', onlineDate='null', pubDate='1763308800000', pubDateStr='2025-11-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896544684, creator='13701087609', updateTime=1785896721343, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707729324826977, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707729324826978, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706987964822180, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3120, endPage=3124, ext={EN=ArticleExt(id=1291707022374892507, articleId=1291707022140011482, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A case report of fatal traumatic brain injury complicated by propofol infusion syndrome, columnId=1246531412023730850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Medication Comment, runingTitle=null, highlight=null, articleAbstract=

A 55 years old female patient was given propofol medium and long chain fat emulsion injection once, during the operation due to traumatic brain injury (TBI), with no documented adverse drug reactions (ADRs). Postoperative cerebral edema was treated with propofol injectable emulsion sedation to lower intracranial pressure. One day after medication initiation, the patient developed oliguria, darkened urine, elevated creatine kinase, elevated transaminases and electrocardiogram (ECG) changes. The patient responded poorly to fluid resuscitation and hepatoprotective therapy, leading to a presumptive diagnosis of propofol infusion syndrome (PRIS). Three days later withdrawal of propofol symptomatic treatment were administered. The patient’s symptoms and laboratory tests improved, but later death due to heart arrest. This case serves as a reminder that clinicians should be vigilant about the cumulative dose and infusion duration of propofol when treating critically ill patients. The absence of ADRs with previous use don’t entirely preclude the risk of subsequent administration. Early recognition of PRIS is critical. Once patients experience symptoms such as unexplained creatine kinase elevation and ECG changes, early diagnosis, timely drug withdrawal and symptomatic treatment measures such as hemofiltration should be taken to ensure medication safety.

, authors=Xu GAO^1a, Xing-hong LI^1b, Xiao-yu JÜ^1a, Wen-xi ZHANG^1a, Jie CHENG^1a, authorsList=Xu GAO, Xing-hong LI, Xiao-yu JÜ, Wen-xi ZHANG, Jie CHENG, authorCompany=null, correspAuthors=Jie CHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707022697853916, articleId=1291707022140011482, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=1例创伤性脑损伤合并丙泊酚输注综合征致死的病例分析, columnId=1246531412271194800, journalTitle=中国临床药理学杂志, columnName=用药点评, runingTitle=null, highlight=null, articleAbstract=

1例55岁患者，女性，因创伤性脑损伤（TBI）术中给予丙泊酚中/长链脂肪乳注射液，期间未发生药物不良反应。术后因脑水肿给予丙泊酚乳状注射液镇静降颅压。用药1天后患者出现尿少，尿色加深，肌酸激酶升高、转氨酶升高，心电图改变等表现。补液、护肝治疗效果不佳，考虑为丙泊酚输注综合征（PRIS）。3天后停用丙泊酚，并对症治疗，患者的症状及实验室检查好转，后心脏骤停死亡。本案例提醒临床应关注危重病患者丙泊酚累积剂量、输注时长等因素，患者既往用药未出现药物不良反应，并不意味着后续用药不会发生药物不良反应。丙泊酚输注综合征的早期的识别至关重要，一旦出现不明原因肌酸激酶升高、心电图改变等表现，临床应提高警觉，早判断、及时停药，尽早给予血液滤过等对症治疗措施，保障用药安全。

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高旭（1987-），女，主管药师，主要从事临床药学相关工作

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高旭（1987-），女，主管药师，主要从事临床药学相关工作

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