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The conjugation and integration of functional molecules have emerged as a core innovative direction in the biomedical field, driving the innovation and upgrading of biotechnology across multiple domains including imaging, detection, and therapy. As a class of novel functional biomolecules, antibody-oligonucleotide conjugates (AOCs) achieve the precise combination of monoclonal antibodies and oligonucleotides through chemical conjugation or bioengineering technologies. They not only inherit the advantage of antibodies in specific targeted delivery but also possess the gene expression regulation function of oligonucleotides, gaining increasing attention in the field of modern biotechnology in recent years. This article systematically sorts out the structural composition, core characteristics, and key technological breakthroughs of AOCs, focusing on analyzing their application scenarios and research status in clinical detection and disease treatment, aiming to provide a reference for the independent research and development, technological innovation, and industrial transformation of AOC drugs in China.

, authors=Zeng-ping XU, Tao SUN, authorsList=Zeng-ping XU, Tao SUN, authorCompany=null, correspAuthors=Tao SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707009334796388, articleId=1291707008823091298, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=抗体-寡核苷酸偶联物研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

功能分子的偶联整合已成为生物医学领域的核心创新方向，推动了成像、检测及治疗等多领域生物技术的革新升级。抗体-寡核苷酸偶联物（AOC）作为一类新型功能生物分子，通过化学偶联或生物工程技术实现单克隆抗体与寡核苷酸的精准结合，既承袭了抗体的特异性靶向递送优势，又兼具寡核苷酸的基因表达调控功能，近年来在现代生物技术领域的关注度持续攀升。本文系统梳理了AOC的结构组成、核心特性及关键技术突破，重点分析其在临床检测与疾病治疗中的应用场景及研发现状，旨在为我国AOC药物的自主研发、技术创新及产业转化提供参考依据。

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许曾平（1990-），男，主管药师，主要从事新药药理毒理审评工作

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许曾平（1990-），男，主管药师，主要从事新药药理毒理审评工作

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