Article(id=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1760457600000, receivedDateStr=2025-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896549342, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896549342, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896549342, creator=13701087609, updateTime=1785896549342, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3530, endPage=3535, ext={EN=ArticleExt(id=1291707007963263794, articleId=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism, columnId=1246531412023730850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Medication Comment, runingTitle=null, highlight=null, articleAbstract=
Objective

To provide anticoagulation recommendations and optimize pharmacotherapy for a patient with lower extremity arterial embolism following aortic valve replacement by integrating pharmacogenomics and drug-drug interactions with medication education.

Methods

A clinical pharmacist participated in the anticoagulation therapy and medication monitoring for a patient who underwent emergency surgery due to lower extremity arterial embolism after mechanical aortic valve replacement. Based on an analysis of the patient′s individual condition and clinical characteristics, and with reference to guidelines and evidence-based literature, the clinical pharmacist guided the perioperative anticoagulation regimen. Factors influencing the effect of warfarin were also analyzed to optimize its dosage.

Results

The patient′s lower extremity arterial embolism improved, and the patient was discharged with favorable follow-up outcomes.

Conclusion

This case provides a reference for clinical pharmacists in managing anticoagulation therapy for patients with lower extremity arterial embolism after mechanical heart valve replacement.

, authors=Wei-wei ZHANG1a, 2, 3, Kang SHE1b, Min YANG1b, Zi-ning WANG1a, authorsList=Wei-wei ZHANG, Kang SHE, Min YANG, Zi-ning WANG, authorCompany=null, correspAuthors=Zi-ning WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707008667906867, articleId=1291707007497696049, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护, columnId=1246531412271194800, journalTitle=中国临床药理学杂志, columnName=用药点评, runingTitle=null, highlight=null, articleAbstract=
目的

结合药物基因组学、药物相互作用及用药教育的综合药学服务为1例主动脉瓣瓣膜置换术后下肢动脉栓塞患者提供及优化抗凝药物使用方案。

方法

临床药师参与1例主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞并进行紧急手术患者的抗凝治疗及用药监护,通过对患者个体情况及病情特点进行分析,同时结合指南、文献相关循证依据,对患者围手术期抗凝方案进行指导,同时对影响华法林作用的因素进行分析并优化其使用剂量。

结果

患者下肢动脉栓塞好转出院,后续随访良好。

结论

本例报告为临床药师针对心脏机械瓣膜置换术后发生下肢动脉栓塞患者提供相关抗凝用药参考。

, authors=张微微1a, 2, 3, 佘康1b, 杨敏1b, 王梓凝1a, authorsList=张微微, 佘康, 杨敏, 王梓凝, authorCompany=null, correspAuthors=王梓凝, authorNote=

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

, correspAuthorsNote=
王梓凝,副主任药师 Tel: (010)83575892 E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=l1IYRLSeBh6MRJSb91ny4g==, magXml=mgPZWmGFMXn9Cz4MLIe+fg==, pdfUrl=null, pdf=RQSGYaOecVO6m57n4+QLkQ==, pdfFileSize=1241344, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=95Sc1I1p+qj14kRBIQoBNQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291707009896837953, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010018472773, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707009896837953, language=EN, stringName=Wei-wei ZHANG, firstName=Wei-wei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, 2, 3, address=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010320462662, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707009896837953, language=CN, stringName=张微微, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, 2, 3, address=1a.北京大学 第一医院 药剂科,北京 100034
2.清华大学 北京清华长庚医院 临床药学科,北京 102218
3.清华大学 化学工程系,北京 100084, bio={"content":"

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

"}, bioImg=null, bioContent=

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009095725876, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1a., ext=[AuthorCompanyExt(id=1291707009108308789, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009112503094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.北京大学 第一医院 药剂科,北京 100034)]), AuthorCompany(id=1291707009489990458, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=2., ext=[AuthorCompanyExt(id=1291707009498379067, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China), AuthorCompanyExt(id=1291707009502573372, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.清华大学 北京清华长庚医院 临床药学科,北京 102218)]), AuthorCompany(id=1291707009582265149, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=3., ext=[AuthorCompanyExt(id=1291707009590653758, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China), AuthorCompanyExt(id=1291707009599042367, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.清华大学 化学工程系,北京 100084)])]), Author(id=1291707010404348744, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010492429130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010404348744, language=EN, stringName=Kang SHE, firstName=Kang, middleName=null, lastName=SHE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010572120907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010404348744, language=CN, stringName=佘康, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.北京大学 第一医院 介入血管外科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009208972087, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1b., ext=[AuthorCompanyExt(id=1291707009217360696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009229943609, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.北京大学 第一医院 介入血管外科,北京 100034)])]), Author(id=1291707010739893069, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010827973455, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010739893069, language=EN, stringName=Min YANG, firstName=Min, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010916053840, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010739893069, language=CN, stringName=杨敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.北京大学 第一医院 介入血管外科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009208972087, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1b., ext=[AuthorCompanyExt(id=1291707009217360696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009229943609, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.北京大学 第一医院 介入血管外科,北京 100034)])]), Author(id=1291707010991551314, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangzining0904@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291707011088020308, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010991551314, language=EN, stringName=Zi-ning WANG, firstName=Zi-ning, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, address=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707011213849429, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010991551314, language=CN, stringName=王梓凝, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, address=1a.北京大学 第一医院 药剂科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009095725876, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1a., ext=[AuthorCompanyExt(id=1291707009108308789, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009112503094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.北京大学 第一医院 药剂科,北京 100034)])])], keywords=[Keyword(id=1291707011331289942, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=EN, orderNo=1, keyword=warfarin), Keyword(id=1291707011415176023, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=EN, orderNo=2, keyword=mechanical prosthetic aortic valve replacement), Keyword(id=1291707011494867800, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=EN, orderNo=3, keyword=lower extremity arterial embolism), Keyword(id=1291707011595531097, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=EN, orderNo=4, keyword=pharmaceutical care), Keyword(id=1291707011692000090, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=CN, orderNo=1, keyword=华法林), Keyword(id=1291707011767497563, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=CN, orderNo=2, keyword=主动脉瓣机械瓣膜置换), Keyword(id=1291707011838800732, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=CN, orderNo=3, keyword=下肢动脉栓塞), Keyword(id=1291707011931075421, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, language=CN, orderNo=4, keyword=药学监护)], refs=null, funds=null, companyList=[AuthorCompany(id=1291707009095725876, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1a., ext=[AuthorCompanyExt(id=1291707009108308789, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009112503094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.北京大学 第一医院 药剂科,北京 100034)]), AuthorCompany(id=1291707009208972087, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1b., ext=[AuthorCompanyExt(id=1291707009217360696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009229943609, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.北京大学 第一医院 介入血管外科,北京 100034)]), AuthorCompany(id=1291707009489990458, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=2., ext=[AuthorCompanyExt(id=1291707009498379067, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China), AuthorCompanyExt(id=1291707009502573372, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.清华大学 北京清华长庚医院 临床药学科,北京 102218)]), AuthorCompany(id=1291707009582265149, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=3., ext=[AuthorCompanyExt(id=1291707009590653758, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China), AuthorCompanyExt(id=1291707009599042367, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.清华大学 化学工程系,北京 100084)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.24.013, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.24.013, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.24.013, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.24.013, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1766851200000, fullTextJson=null, articleText=null, reference=null)
收藏切换
主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护
收藏切换
PDF下载
张微微 1a, 2, 3 , 佘康 1b , 杨敏 1b , 王梓凝 1a
中国临床药理学杂志 | 用药点评 2025,41(24): 3530-3535
收起
收藏切换
中国临床药理学杂志 |用药点评 2025 , 41 (24) : 3530 -3535
主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护
全屏
[Author(id=1291707009896837953, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010018472773, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707009896837953, language=EN, stringName=Wei-wei ZHANG, firstName=Wei-wei, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, 2, 3, address=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010320462662, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707009896837953, language=CN, stringName=张微微, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, 2, 3, address=1a.北京大学 第一医院 药剂科,北京 100034
2.清华大学 北京清华长庚医院 临床药学科,北京 102218
3.清华大学 化学工程系,北京 100084, bio={"content":"

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

"}, bioImg=null, bioContent=

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009095725876, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1a., ext=[AuthorCompanyExt(id=1291707009108308789, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009112503094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.北京大学 第一医院 药剂科,北京 100034)]), AuthorCompany(id=1291707009489990458, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=2., ext=[AuthorCompanyExt(id=1291707009498379067, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China), AuthorCompanyExt(id=1291707009502573372, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009489990458, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.清华大学 北京清华长庚医院 临床药学科,北京 102218)]), AuthorCompany(id=1291707009582265149, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=3., ext=[AuthorCompanyExt(id=1291707009590653758, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China), AuthorCompanyExt(id=1291707009599042367, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009582265149, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.清华大学 化学工程系,北京 100084)])]), Author(id=1291707010404348744, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010492429130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010404348744, language=EN, stringName=Kang SHE, firstName=Kang, middleName=null, lastName=SHE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010572120907, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010404348744, language=CN, stringName=佘康, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.北京大学 第一医院 介入血管外科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009208972087, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1b., ext=[AuthorCompanyExt(id=1291707009217360696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009229943609, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.北京大学 第一医院 介入血管外科,北京 100034)])]), Author(id=1291707010739893069, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291707010827973455, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010739893069, language=EN, stringName=Min YANG, firstName=Min, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707010916053840, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010739893069, language=CN, stringName=杨敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1b, address=1b.北京大学 第一医院 介入血管外科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009208972087, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1b., ext=[AuthorCompanyExt(id=1291707009217360696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009229943609, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009208972087, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1b.北京大学 第一医院 介入血管外科,北京 100034)])]), Author(id=1291707010991551314, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangzining0904@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291707011088020308, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010991551314, language=EN, stringName=Zi-ning WANG, firstName=Zi-ning, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, address=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291707011213849429, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, authorId=1291707010991551314, language=CN, stringName=王梓凝, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1a, address=1a.北京大学 第一医院 药剂科,北京 100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291707009095725876, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, xref=1a., ext=[AuthorCompanyExt(id=1291707009108308789, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1291707009112503094, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291707007497696049, companyId=1291707009095725876, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1a.北京大学 第一医院 药剂科,北京 100034)])])]
张微微1a, 2, 3, 佘康1b, 杨敏1b, 王梓凝1a
作者信息
  • 1a.北京大学 第一医院 药剂科,北京 100034
  • 1b.北京大学 第一医院 介入血管外科,北京 100034
  • 2.清华大学 北京清华长庚医院 临床药学科,北京 102218
  • 3.清华大学 化学工程系,北京 100084
通讯作者:
王梓凝,副主任药师 Tel: (010)83575892 E-mail:
作者简介:

张微微(1983-),女,主管药师,主要从事临床药学及医工交叉研究

Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism
Wei-wei ZHANG1a, 2, 3, Kang SHE1b, Min YANG1b, Zi-ning WANG1a
Affiliations
  • 1a.Department of Pharmacy, Peking University First Hospital, Beijing 100034, China
  • 1b.Department of Interventional Vascular Surgery, Peking University First Hospital, Beijing 100034, China
  • 2.Department of Clinical Pharmacy, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China
  • 3.Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
出版时间: 2025-12-28 doi: 10.13699/j.cnki.1001-6821.2025.24.013
文章导航
收藏切换
目的

结合药物基因组学、药物相互作用及用药教育的综合药学服务为1例主动脉瓣瓣膜置换术后下肢动脉栓塞患者提供及优化抗凝药物使用方案。

方法

临床药师参与1例主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞并进行紧急手术患者的抗凝治疗及用药监护,通过对患者个体情况及病情特点进行分析,同时结合指南、文献相关循证依据,对患者围手术期抗凝方案进行指导,同时对影响华法林作用的因素进行分析并优化其使用剂量。

结果

患者下肢动脉栓塞好转出院,后续随访良好。

结论

本例报告为临床药师针对心脏机械瓣膜置换术后发生下肢动脉栓塞患者提供相关抗凝用药参考。

华法林  /  主动脉瓣机械瓣膜置换  /  下肢动脉栓塞  /  药学监护
Objective

To provide anticoagulation recommendations and optimize pharmacotherapy for a patient with lower extremity arterial embolism following aortic valve replacement by integrating pharmacogenomics and drug-drug interactions with medication education.

Methods

A clinical pharmacist participated in the anticoagulation therapy and medication monitoring for a patient who underwent emergency surgery due to lower extremity arterial embolism after mechanical aortic valve replacement. Based on an analysis of the patient′s individual condition and clinical characteristics, and with reference to guidelines and evidence-based literature, the clinical pharmacist guided the perioperative anticoagulation regimen. Factors influencing the effect of warfarin were also analyzed to optimize its dosage.

Results

The patient′s lower extremity arterial embolism improved, and the patient was discharged with favorable follow-up outcomes.

Conclusion

This case provides a reference for clinical pharmacists in managing anticoagulation therapy for patients with lower extremity arterial embolism after mechanical heart valve replacement.

warfarin  /  mechanical prosthetic aortic valve replacement  /  lower extremity arterial embolism  /  pharmaceutical care
张微微, 佘康, 杨敏, 王梓凝. 主动脉瓣机械瓣膜置换术后合并下肢动脉栓塞抗凝治疗的药学监护. 中国临床药理学杂志, 2025 , 41 (24) : 3530 -3535 . DOI: 10.13699/j.cnki.1001-6821.2025.24.013
Wei-wei ZHANG, Kang SHE, Min YANG, Zi-ning WANG. Pharmaceutical care for anticoagulation therapy following mechanical aortic valve replacement complicated by lower extremity arterial embolism[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (24) : 3530 -3535 . DOI: 10.13699/j.cnki.1001-6821.2025.24.013

参考文献 引证文献
排序方式:
2025年第41卷第24期
PDF下载
145
22
引用本文
BibTeX
文章信息
doi: 10.13699/j.cnki.1001-6821.2025.24.013
  • 接收时间:2025-10-15
  • 首发时间:2026-08-05
  • 出版时间:2025-12-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2025-10-15
基金
作者信息
    1a.北京大学 第一医院 药剂科,北京 100034
    1b.北京大学 第一医院 介入血管外科,北京 100034
    2.清华大学 北京清华长庚医院 临床药学科,北京 102218
    3.清华大学 化学工程系,北京 100084

通讯作者:

王梓凝,副主任药师 Tel: (010)83575892 E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.24.013
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏