Article(id=1291707003785732155, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1746633600000, receivedDateStr=2025-05-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896548457, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896548457, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896548457, creator=13701087609, updateTime=1785896548457, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3465, endPage=3470, ext={EN=ArticleExt(id=1291707004909805632, articleId=1291707003785732155, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of duloxetine combined with
Bifidobacterium quadruple live bacteria tablets in patients with depression accompanied by gastrointestinal disorders, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of duloxetine hydrochloride enteric-coated capsules combined with Bifidobacterium quadruple live bacteria tablets in patients with depression accompanied by gastrointestinal disorders.
Methods According to the treatment method, patients with depression and gastrointestinal dysfunction were divided into control group and treatment group. The control group took 30 mg duloxetine hydrochloride enteric-coated capsules once a day after breakfast, and adjusted to 60 mg once a day after 1 week. The treatment group was combined with 1.5 g Bifidobacterium quadruple viable tablets, 3 times a day. Both groups were treated for 8 weeks. The clinical therapeutic effects, and intestinal microbiota composition of the two groups of patients were compared, and safety evaluation was conducted.
Results A total of 76 patients were enrolled, 32 patients were included in the control group and 44 patients in the treatment group. After treatment, the total effective rate of the treatment group was 84.09% (37 cases /44 cases), and that of control group was 62.50% (20 cases/32 cases), and the difference was statistically significant (P<0.05). After treatment, the Lactobacillus of treatment group and control group were (7.14±1.14) and (6.54±1.24) lg CFU·g-1, respectively; Staphylococcus were (3.73±0.73) and (4.12±0.74) lg CFU·g-1, respectively; Bifidobacterium were (8.39±1.44) and (7.69±1.34) lg CFU·g-1, respectively; Escherichia coli were (7.08±0.93) and (7.52±0.81) lg CFU·g-1, respectively; Enterococcus faecalis were (5.95±0.76) and (6.50±0.84) lg CFU·g-1, respectively. The above indicators of treatment group were compared with those of the control group, and the differences were statistically significant (all P<0.05). The adverse drug reactions in the treatment group mainly included nausea, dry mouth, constipation, insomnia and dizziness. The adverse drug reactions in the control group mainly included palpitations, nausea, dry mouth, constipation, insomnia and dizziness. The total incidence of adverse drug reactions in the treatment group and the control group were 15.91% (7 cases /44 cases) and 40.63% (13 cases /32 cases), respectively, with no statistically significant different (P<0.05).
Conclusion Duloxetine hydrochloride enteric-coated capsules combined with Bifidobacterium quadruflora live bacteria tablets have a good clinical efficacy in patients with depression accompanied by gastrointestinal disorders. They can improve the intestinal flora of patients and reduce the occurrence of adverse drug reactions.
, authors=Wei-wei LI
a, Lu WANG
a, Jing CHEN
b, authorsList=Wei-wei LI, Lu WANG, Jing CHEN, authorCompany=null, correspAuthors=Lu WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291707005455065153, articleId=1291707003785732155, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=度洛西汀联合双歧杆菌四联活菌片在抑郁症伴胃肠紊乱患者中的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察盐酸度洛西汀肠溶胶囊联合双歧杆菌四联活菌片对抑郁症伴胃肠紊乱患者的临床疗效及安全性。
方法 根据治疗方式将抑郁症伴胃肠功能紊乱患者分为对照组和试验组。对照组早餐饭后口服30 mg盐酸度洛西汀肠溶胶囊，每天1次，1 w后调整为60 mg，每天1次。试验组于对照组基础上联合1.5 g双歧杆菌四联活菌片口服，每天3次。2组均治疗8 w。对比2组患者的临床治疗效果和肠道菌群，并进行安全性评价。
结果 本研究共纳入76例患者，对照组纳入32例，试验组纳入44例。治疗后，试验组的总有效率为84.09%（37例/44例），对照组的总有效率为62.50%（20例/32例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的乳杆菌分别为（7.14±1.14）和（6.54±1.24）lg CFU·g-1，葡萄球菌分别为（3.73±0.73）和（4.12±0.74）lg CFU·g-1，双歧杆菌分别为（8.39±1.44）和（7.69±1.34）lg CFU·g-1，大肠杆菌分别为（7.08±0.93）和（7.52±0.81）lg CFU·g-1，粪肠球菌分别为（5.95±0.76）和（6.50±0.84）lg CFU·g-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要包括恶心、口干、便秘、失眠和眩晕；对照组的主要有心悸、恶心、口干、便秘、失眠、眩晕。试验组与对照组的总药物不良反应发生率分别为15.91%（7例/44例）和40.63%（13例/32例），在统计学上差异有统计学意义（P<0.05）。
结论 盐酸度洛西汀肠溶胶囊联合双歧杆菌四联活菌片对抑郁症伴胃肠紊乱患者的临床疗效好，能改善患者肠道菌群，且能够降低药物不良反应发生情况。
, authors=李薇薇
a, 王鹭
a, 陈晶
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