Article(id=1291706974404637250, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1756742400000, receivedDateStr=2025-09-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896541452, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896541452, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896541452, creator=13701087609, updateTime=1785896541452, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3477, endPage=3481, ext={EN=ArticleExt(id=1291706974610158147, articleId=1291706974404637250, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Surveillance of antimicrobial in
Klebsiella pneumoniae in Xinjiang region from 2019 to 2023, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To understand the distribution and antibiotic resistance changes of clinical isolated Klebsiella pneumoniae in Xinjiang from 2019 to 2023, and provide a basis for the rational use of antibiotics in clinical practice.
Methods Clinical isolates from Xinjiang region between 2019 and 2023 were collectd and identified and subjected to drug sensitivity tests using the fully automated bacterial identification analyzer VITEK-2 compact and VITEK-MS, supplemented by the K-B paper method.
Results Over the course of 5 years, a total of 72 678 strains of Klebsiella pneumoniae were detected, among which 19 061 were extended-spectrum β-lactamases (ESBLs) producing strains, accounting for a detection rate of 26.23%. The strains mainly come from sputum, urine, blood, etc. The top three departments in terms of strain distribution were the intensive care medicine, respiratory medicine, and pediatrics. The resistance rates of Klebsiella pneumoniae to third-generation cephalosporins ceftriaxone and ceftazidime were 21.42% and 15.73%, respectively. The resistance rates to carbapenems ranged from 6.82% to 7.48%, and the resistance rate to amikacin was 4.15%.
Conclusion Klebsiella pneumoniae has become one of the most common pathogenic bacteria in clinical practice. The resistance of Klebsiella pneumoniae detected in Xinjiang is not optimistic. In order to improve the treatment effect of antibiotics, the resistance of antibiotics in the local area should be continuously monitored, and antibiotics should be selected reasonably based on drug sensitivity results.
, authors=RENAGU·Aishan
1, Na CHEN
2, Ping JI
2, authorsList=RENAGU·Aishan, Na CHEN, Ping JI, authorCompany=null, correspAuthors=Ping JI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706974920536644, articleId=1291706974404637250, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=2019~2023年新疆地区肺炎克雷伯菌耐药性监测, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 了解2019~2023年新疆地区临床分离肺炎克雷伯菌的分布及耐药变迁，为临床合理使用抗菌药物提供依据。
方法 收集2019~2023年新疆地区住院病人送检的标本，用全自动细菌鉴定分析仪VITEK-2 compact和VITEK-MS对临床分离株进行菌株鉴定并进行药敏试验，用K-B纸片法做补充。
结果 5年间共检出肺炎克雷伯菌72 678株，其中产超广谱β-内酰胺酶（ESBLs）菌株19 061株，检出率为26.23%。菌株主要来源于痰液、尿液、血液等。科室分布前3位的是重症医学科、呼吸科和儿科。肺炎克雷伯菌对第三代头孢菌素头孢曲松和头孢他啶耐药率分别为21.42%和15.73%。对碳青霉烯类耐药率在6.82%~7.48%；对阿米卡星耐药率为4.15%。
结论 肺炎克雷伯菌已成为临床最常见的致病菌之一，新疆地区检出的肺炎克雷伯菌耐药情况不容乐观，为了提高抗菌药物的治疗效果，应连续监测本地区的抗菌药物的耐药情况，根据药敏结果合理选用抗菌药物。
, authors=热那古·艾山
1, 陈娜
2, 季萍
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热那古·艾山（1991-），女，主管检验师，主要从事细菌耐药机制研究
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