Article(id=1291706967614059042, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.24.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896539834, onlineDateStr=2026-08-05, pubDate=1766851200000, pubDateStr=2025-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896539834, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896539834, creator=13701087609, updateTime=1785896539834, updator=13701087609, issue=Issue{id=1291706966187991876, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='24', pageStart='3451', pageEnd='3600', issueExtLink='null', onlineDate='null', pubDate='1766851200000', pubDateStr='2025-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896539494, creator='13701087609', updateTime=1785998798662, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292135872292479273, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292135872296673578, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291706966187991876, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3471, endPage=3476, ext={EN=ArticleExt(id=1291706969325335075, articleId=1291706967614059042, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trail of therapeutic effect of emedastine difumarate sustained-release capsules combined with tacrolimus ointment on senile skin pruritus patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of emedastine difumarate sustained-release capsules in conjunction with tacrolimus ointment for treating elderly patients with skin pruritus.
Methods The senile patients with pruritus who were treated in our hospital were divided into control group and treatment group according to the treatment methods. The control group was treated with tacrolimus ointment twice a day on the basis of conventional treatment for 6 consecutive weeks. The treatment group, on the basis of the control group, orally administered 2 mg of emestine fumarate sustained-release capsules after breakfast or before going to bed, twice a day for 6 consecutive weeks. The clinical efficacy of patients, evaluation of itching degree, the levels of eosinophils (EOS), histamine and immunoglobulin E (IgE), levels of inflammatory response indicators recurrence situation, and safety were compared between two groups.
Results A total of 122 cases were included in this study, including 59 cases in the control group and 63 cases in the treatmnet group. The total effective rates of treatment in the treatmnet group and the control group were 92.06% (58 cases/63 cases) and 76.27% (45 cases/59 cases), respectively; the pruritus degree scores were (2.35±0.48) and (2.64±0.52) points, respectively; the EOS were (208.07±33.69) and (225.61±34.82) ×106·L-1 respectively; the histamine was (0.79±0.13) and (1.25±0.21) ng·mL-1, respectively; the IgE was (42.07±6.56) and (45.17±6.08) ng·mL-1, respectively; the monocyte chemoattractant protein-1 was (279.77±39.14) and (298.52±47.64) pg·mL-1, respectively; the eosinophil chemoattractant was (44.77±6.21) and (47.96±7.45) pg·mL-1, respectively; the interleukin-6 was (6.56±1.07) and (7.13±1.08) pg·mL-1, respectively; the tumor necrosis factor -α was (5.91±0.69) and (6.24±0.89) pg·mL-1, respectively, and the recurrence rates were 11.11% and 25.42%, respectively. The comparison of above indicators showed that there were statistically significant differences between the two groups (P<0.05, P<0.01, P<0.001). The adverse reactions in the control group included a burning sensation on the skin and rosacea, while those in the treatmnet group included a burning sensation on the skin, rosacea, drowsiness, headache, dizziness and tinnitus. The adverse reaction rates of the control group and the treatmnet group were 11.86% and 19.05%, without tatistically significant difference (P>0.05).
Conclusion Emedastine difumarate sustained-release capsules combined with tacrolimus ointment can alleviate patients′ pruritus symptoms, reduce inflammatory response, regulate immune function, improve efficacy and reduce the risk of recurrence without increasing adverse reactions.
, authors=Hong-juan SONG, Guo-an MA, Xin ZHANG, authorsList=Hong-juan SONG, Guo-an MA, Xin ZHANG, authorCompany=null, correspAuthors=Hong-juan SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291706970457797156, articleId=1291706967614059042, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=依美斯汀缓释胶囊联合他克莫司软膏治疗老年性皮肤瘙痒症患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察富马酸依美斯汀缓释胶囊与他克莫司软膏联合使用，对老年性皮肤瘙痒症患者的临床疗效和安全性。
方法 将老年性皮肤瘙痒症患者，按照治疗方法分为对照组和试验组。对照组在常规治疗基础上涂抹他克莫司软膏，每天2次，连续治疗6 w。试验组在对照组基础上另于早餐后或临睡前口服富马酸依美斯汀缓释胶囊2 mg，每天2次，连续给药6 w。比较2组患者的临床疗效、瘙痒程度评分、嗜酸性粒细胞（EOS）、组胺、免疫球蛋白E（IgE）水平、炎症反应指标水平及复发情况并进行安全性评价。
结果 本研究共纳入122例，其中对照组59例，试验组63例。试验组和对照组治疗总有效率分别为92.06%（58例/63例）和76.27%（45例/59例），瘙痒程度评分分别为（2.35±0.48）和（2.64±0.52）分，EOS分别为（208.07±33.69）和（225.61±34.82）×106·L-1，组胺分别为（0.79±0.13）和（1.25±0.21）ng·mL-1，IgE分别为（42.07±6.56）和（45.17±6.08）ng·mL-1，单核细胞趋化蛋白-1分别为（279.77±39.14）和（298.52±47.64）pg·mL-1，嗜酸性粒细胞趋化因子分别为（44.77±6.21）和（47.96±7.45）pg·mL-1，白细胞介素-6分别为（6.56±1.07）和（7.13±1.08）pg·mL-1，肿瘤坏死因子-α分别为（5.91±0.69）和（6.24±0.89）pg·mL-1，复发率分别为11.11%和25.42%，上述指标在2组间比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。对照组的药物不良反应包括皮肤灼烧感、红斑痤疮，试验组的药物不良反应包括皮肤灼烧感、红斑痤疮、倦睡、头痛、头晕、耳鸣。对照组和试验组的药物不良反应率分别为11.86%（7例/59例）和19.05%（12例/63例），在统计学上差异无统计学意义（P>0.05）。
结论 富马酸依美斯汀缓释胶囊联合他克莫司软膏能改善患者瘙痒症状，减轻炎症反应，调节免疫功能，提升疗效并降低复发风险，且不增加药物不良反应。
, authors=宋红娟, 马国安, 张鑫, authorsList=宋红娟, 马国安, 张鑫, authorCompany=null, correspAuthors=宋红娟, authorNote=
宋红娟（1982-），女，副主任医师，主要从事瘙痒性皮肤病诊疗方面的临床工作和研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=TjYY1vRkqhUrksOIT9jttw==, magXml=Gv7Hcum5/UiYFPRV9nMW6g==, pdfUrl=null, pdf=DwQbi+ZKPAO4lUIWeosn0Q==, pdfFileSize=1253106, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=OOV7JiUuNr/lrs9ZC9zlCQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291706970772369961, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=sshhjj1982@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291706970894004779, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706970772369961, language=EN, stringName=Hong-juan SONG, firstName=Hong-juan, middleName=null, lastName=SONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291706970969502252, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706970772369961, language=CN, stringName=宋红娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=衡水市人民医院 皮肤科，河北 衡水 053000, bio={"content":"
宋红娟（1982-），女，副主任医师，主要从事瘙痒性皮肤病诊疗方面的临床工作和研究
"}, bioImg=null, bioContent=
宋红娟（1982-），女，副主任医师，主要从事瘙痒性皮肤病诊疗方面的临床工作和研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291706970663318053, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, xref=null, ext=[AuthorCompanyExt(id=1291706970667512358, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China), AuthorCompanyExt(id=1291706970684289575, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=衡水市人民医院 皮肤科，河北 衡水 053000)])]), Author(id=1291706971049194030, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291706971133080112, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706971049194030, language=EN, stringName=Guo-an MA, firstName=Guo-an, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291706971200188977, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706971049194030, language=CN, stringName=马国安, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=衡水市人民医院 皮肤科，河北 衡水 053000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291706970663318053, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, xref=null, ext=[AuthorCompanyExt(id=1291706970667512358, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China), AuthorCompanyExt(id=1291706970684289575, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=衡水市人民医院 皮肤科，河北 衡水 053000)])]), Author(id=1291706971271492147, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291706971384738357, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706971271492147, language=EN, stringName=Xin ZHANG, firstName=Xin, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291706971456041526, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, authorId=1291706971271492147, language=CN, stringName=张鑫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=衡水市人民医院 皮肤科，河北 衡水 053000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291706970663318053, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, xref=null, ext=[AuthorCompanyExt(id=1291706970667512358, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China), AuthorCompanyExt(id=1291706970684289575, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=衡水市人民医院 皮肤科，河北 衡水 053000)])])], keywords=[Keyword(id=1291706971573482039, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=EN, orderNo=1, keyword=emedastine difumarate sustained-release capsule), Keyword(id=1291706971640590904, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=EN, orderNo=2, keyword=tacrolimus ointment), Keyword(id=1291706971728671289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=EN, orderNo=3, keyword=senile skin pruritus), Keyword(id=1291706971804168762, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=EN, orderNo=4, keyword=inflammatory response), Keyword(id=1291706971888054843, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=EN, orderNo=5, keyword=immune function), Keyword(id=1291706971967746620, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=CN, orderNo=1, keyword=富马酸依美斯汀缓释胶囊), Keyword(id=1291706973670634046, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=CN, orderNo=2, keyword=他克莫司软膏), Keyword(id=1291706973758714431, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=CN, orderNo=3, keyword=老年性皮肤瘙痒症), Keyword(id=1291706973846794816, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=CN, orderNo=4, keyword=炎症反应), Keyword(id=1291706973922292289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, language=CN, orderNo=5, keyword=免疫功能)], refs=null, funds=null, companyList=[AuthorCompany(id=1291706970663318053, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, xref=null, ext=[AuthorCompanyExt(id=1291706970667512358, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Dermatology, Hengshui People′s Hospital, Hengshui 053000, Hebei Province, China), AuthorCompanyExt(id=1291706970684289575, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291706967614059042, companyId=1291706970663318053, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=衡水市人民医院 皮肤科，河北 衡水 053000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.24.004, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.24.004, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.24.004, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.24.004, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1766851200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
170
29
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
