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Article(id=1291705003857699030, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752595200000, receivedDateStr=2025-07-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896071637, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896071637, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896071637, creator=13701087609, updateTime=1785896071637, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2941, endPage=2947, ext={EN=ArticleExt(id=1291705004054831319, articleId=1291705003857699030, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy and safety of ceftolozane/tazobactam in the treatment of gram-negative bacterial infections: A systematic review and Meta-analysis, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective

This study systematically evaluated its clinical efficacy and safety of ceftolozane/tazobactam for gram-negative bacterial (GNB) infections.

Methods

Clinical studies on ceftolozane/tazobactam for GNB infections were retrieved from PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang databases from inception to April 2025. Study quality was assessed using the Cochrane Risk of Bias tool and Newcastle-Ottawa Scale (NOS). Meta-analysis was performed using RevMan 5.4.1.

Results

Twenty-two studies involving 5 728 patients were included. Ceftolozane/tazobactam demonstrated superior clinical efficacy against Pseudomonas aeruginosa infections compared to control drugs (OR=1.61; 95% CI: 1.07-2.42; I2=60%; P=0.02) and significantly higher bacterial eradication rates (OR=1.27; 95% CI: 1.05-1.55; I2=11%; P=0.01). No significant differences were observed in adverse event rates (OR=0.90; 95% CI: 0.70-1.15; I2=55%; P=0.40), serious adverse event rates (OR=0.83; 95% CI: 0.53-1.29; I2=73%; P=0.40), or all-cause mortality (OR=0.92; 95% CI: 0.78-1.10; I2=0%; P=0.37).

Conclusion

For GNB infections, ceftolozane/tazobactam exhibits non-inferior clinical efficacy and safety to comparator drugs with higher bacterial eradication rates. It may represent a preferred alternative for Pseudomonas aeruginosa nfections.

, authors=Yun-pei ZHAO1, 2, Jun YANG1, Ge YANG1, Jie QIN2, Lin-li XIE1, Yong-chuan CHEN1, authorsList=Yun-pei ZHAO, Jun YANG, Ge YANG, Jie QIN, Lin-li XIE, Yong-chuan CHEN, authorCompany=null, correspAuthors=Yong-chuan CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291705004562342104, articleId=1291705003857699030, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=头孢洛扎/他唑巴坦治疗革兰阴性菌感染的有效性与安全性：系统综述及Meta分析, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的

本研究对头孢洛扎/他唑巴坦治疗革兰阴性菌感染的临床有效性和安全性进行系统评价。

方法

检索PubMed、Embase、Cochrane Library、中国知网、维普中文科技期刊、万方数据库建库至2025年4月公开发表的头孢洛扎/他唑巴坦治疗革兰阴性菌感染的临床研究。以Cochrane风险偏倚评估工具、纽卡斯尔-渥太华量表对纳入研究进行质量评价，RevMan 5.4.1软件进行Meta分析。

结果

共纳入22篇文献，5 728例患者，头孢洛扎/他唑巴坦对铜绿假单胞菌感染的临床疗效优于对照组药物（OR=1.61；95%CI：1.07~2.42; I2=60%；P=0.02），且在细菌清除率方面有显著优势（OR=1.27；95%CI：1.05~1.55; I2=11%；P=0.01），在不良反应发生率（OR=0.90；95%CI：0.70~1.15；I2=55%；P=0.40）、严重不良反应发生率（OR=0.83；95%CI：0.53~1.29; I2=73%；P=0.40）及全因死亡率（OR=0.92；95%CI：0.78~1.10; I2=0%；P=0.37）方面未见明显差异。

结论

头孢洛扎/他唑巴坦治疗革兰阴性菌感染时，临床疗效与安全性不劣于对照组药物，且细菌清除率更高；对铜绿假单胞菌感染可能是潜在优选方案。

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赵耘佩（1995-），女，主管护师，主要从事抗菌药物临床药理方面的研究

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陈勇川，副主任药师，硕士生导师 Tel: （023）68766772 E-mail:
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头孢洛扎/他唑巴坦治疗革兰阴性菌感染的有效性与安全性：系统综述及Meta分析
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赵耘佩 1, 2 , 杨君 1 , 杨戈 1 , 秦杰 2 , 谢林利 1 , 陈勇川 1
中国临床药理学杂志 | 读者园地 2025,41(20): 2941-2947
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中国临床药理学杂志 |读者园地 2025 , 41 (20) : 2941 -2947
头孢洛扎/他唑巴坦治疗革兰阴性菌感染的有效性与安全性：系统综述及Meta分析
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赵耘佩1, 2, 杨君1, 杨戈1, 秦杰2, 谢林利1, 陈勇川1
作者信息
  • 1.陆军军医大学 第一附属医院 药剂科，重庆 400038
  • 2.中国人民解放军陆军第七十四集团军医院，广东 广州 510000
通讯作者:
陈勇川，副主任药师，硕士生导师 Tel: （023）68766772 E-mail:
作者简介:

赵耘佩（1995-），女，主管护师，主要从事抗菌药物临床药理方面的研究

Efficacy and safety of ceftolozane/tazobactam in the treatment of gram-negative bacterial infections: A systematic review and Meta-analysis
Yun-pei ZHAO1, 2, Jun YANG1, Ge YANG1, Jie QIN2, Lin-li XIE1, Yong-chuan CHEN1
Affiliations
  • 1.Department of Pharmacy, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China
  • 2.The 74th Group Army Hospital of PLA, Guangzhou 510000, Guangdong Province, China
出版时间: 2025-10-28 doi: 10.13699/j.cnki.1001-6821.2025.20.016
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摘要
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目的

本研究对头孢洛扎/他唑巴坦治疗革兰阴性菌感染的临床有效性和安全性进行系统评价。

方法

检索PubMed、Embase、Cochrane Library、中国知网、维普中文科技期刊、万方数据库建库至2025年4月公开发表的头孢洛扎/他唑巴坦治疗革兰阴性菌感染的临床研究。以Cochrane风险偏倚评估工具、纽卡斯尔-渥太华量表对纳入研究进行质量评价，RevMan 5.4.1软件进行Meta分析。

结果

共纳入22篇文献，5 728例患者，头孢洛扎/他唑巴坦对铜绿假单胞菌感染的临床疗效优于对照组药物（OR=1.61；95%CI：1.07~2.42; I2=60%；P=0.02），且在细菌清除率方面有显著优势（OR=1.27；95%CI：1.05~1.55; I2=11%；P=0.01），在不良反应发生率（OR=0.90；95%CI：0.70~1.15；I2=55%；P=0.40）、严重不良反应发生率（OR=0.83；95%CI：0.53~1.29; I2=73%；P=0.40）及全因死亡率（OR=0.92；95%CI：0.78~1.10; I2=0%；P=0.37）方面未见明显差异。

结论

头孢洛扎/他唑巴坦治疗革兰阴性菌感染时，临床疗效与安全性不劣于对照组药物，且细菌清除率更高；对铜绿假单胞菌感染可能是潜在优选方案。

头孢洛扎/他唑巴坦  /  革兰阴性菌  /  有效性  /  安全性  /  Meta分析
Objective

This study systematically evaluated its clinical efficacy and safety of ceftolozane/tazobactam for gram-negative bacterial (GNB) infections.

Methods

Clinical studies on ceftolozane/tazobactam for GNB infections were retrieved from PubMed, Embase, Cochrane Library, CNKI, VIP, and WanFang databases from inception to April 2025. Study quality was assessed using the Cochrane Risk of Bias tool and Newcastle-Ottawa Scale (NOS). Meta-analysis was performed using RevMan 5.4.1.

Results

Twenty-two studies involving 5 728 patients were included. Ceftolozane/tazobactam demonstrated superior clinical efficacy against Pseudomonas aeruginosa infections compared to control drugs (OR=1.61; 95% CI: 1.07-2.42; I2=60%; P=0.02) and significantly higher bacterial eradication rates (OR=1.27; 95% CI: 1.05-1.55; I2=11%; P=0.01). No significant differences were observed in adverse event rates (OR=0.90; 95% CI: 0.70-1.15; I2=55%; P=0.40), serious adverse event rates (OR=0.83; 95% CI: 0.53-1.29; I2=73%; P=0.40), or all-cause mortality (OR=0.92; 95% CI: 0.78-1.10; I2=0%; P=0.37).

Conclusion

For GNB infections, ceftolozane/tazobactam exhibits non-inferior clinical efficacy and safety to comparator drugs with higher bacterial eradication rates. It may represent a preferred alternative for Pseudomonas aeruginosa nfections.

ceftolozane/tazobactam  /  gram-negative bacteria  /  efficacy  /  safety  /  Meta-analysis
赵耘佩, 杨君, 杨戈, 秦杰, 谢林利, 陈勇川. 头孢洛扎/他唑巴坦治疗革兰阴性菌感染的有效性与安全性：系统综述及Meta分析. 中国临床药理学杂志, 2025 , 41 (20) : 2941 -2947 . DOI: 10.13699/j.cnki.1001-6821.2025.20.016
Yun-pei ZHAO, Jun YANG, Ge YANG, Jie QIN, Lin-li XIE, Yong-chuan CHEN. Efficacy and safety of ceftolozane/tazobactam in the treatment of gram-negative bacterial infections: A systematic review and Meta-analysis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (20) : 2941 -2947 . DOI: 10.13699/j.cnki.1001-6821.2025.20.016

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doi: 10.13699/j.cnki.1001-6821.2025.20.016
  • 接收时间：2025-07-16
  • 首发时间：2026-08-05
  • 出版时间：2025-10-28
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  • 收稿日期：2025-07-16
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    1.陆军军医大学 第一附属医院 药剂科，重庆 400038
    2.中国人民解放军陆军第七十四集团军医院，广东 广州 510000

通讯作者:

陈勇川，副主任药师，硕士生导师 Tel: （023）68766772 E-mail:
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2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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