Article(id=1291705001550828430, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1755187200000, receivedDateStr=2025-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896071087, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896071087, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896071087, creator=13701087609, updateTime=1785896071087, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2407, endPage=2411, ext={EN=ArticleExt(id=1291705001806680975, articleId=1291705001550828430, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial on effects of infection on prognosis of patients with ST segment elevation myocardial infarction, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To develop and validate a simple scoring system for predicting the risk of infection after acute myocardial infarction (AMI) in patients undergoing percutaneous coronary intervention (PCI).
Methods Continuous patients with ST-segment elevation myocardial infarction (STEMI) who received PCI in our hospital were divided into training set and validation set using a cohort approach. All patients received oral rosuvastatin calcium tablets 10-20 mg per day combined with evolocumab injection therapy 140 mg. The primary endpoint was post-AMI infection during hospitalization, while all-cause mortality and major adverse cardiovascular events (MACE) were considered secondary endpoints. The area under the curve (AUC) and the calibration between predicted and observed infection risks were calculated. A backward stepwise logistic regression model was selected to develop the risk score.
Results A total of 359 patients were included, with 217 in the training set and 142 in the validation set, and no patient dropout occurred during the study. A 24-point risk scoring system was developed, with infection risks ranging from 0.70% to 99.60% in patients with the lowest and highest scores, respectively. Seven variables including age, Killip class, insulin use, white blood cell count, serum albumin, diuretics and transfemoral approach were incorporated into the model. The model achieved equally high discrimination in both the development and validation cohorts (C-statistic: 0.85) and demonstrated good calibration in both datasets. In both development and validation cohorts, the incidence of post-myocardial infarction infection increased steadily across risk score groups. Additionally, this risk score exhibited good predictive ability for infection, in-hospital all-cause mortality.
Conclusion This study established a simple bedside tool, a risk scoring system for assessing the risk of infection and other in-hospital outcomes in STEMI patients undergoing PCI. Clinicians can utilize this risk scoring system to evaluate infection risk and make evidence-based decisions accordingly.
, authors=Li-shan ZHU
1, Wen-xin GAO
1, Jia-ying LI
1, Jing LIANG
2, authorsList=Li-shan ZHU, Wen-xin GAO, Jia-ying LI, Jing LIANG, authorCompany=null, correspAuthors=Wen-xin GAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291705003538928528, articleId=1291705001550828430, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=感染对ST段抬高型心肌梗死患者预后影响的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 开发并验证一个简单的评分系统以预测接受经皮冠状动脉介入治疗（PCI）患者在急性心肌梗死（AMI）后发生感染的风险。
方法 将本院就诊的连续接受PCI的ST段抬高型心肌梗死（STEMI）患者按照队列法分为训练集和验证集，所有患者均接受口服瑞舒伐他汀钙片每日10~20 mg，联合依洛尤单抗注射液140 mg注射治疗。主要终点为住院期间的AMI后感染，次要终点为全因死亡和主要不良心血管事件（MACE）。计算受试者工作特征曲线下面积（AUC）以及预测感染风险与观察感染风险的校准。选择向后逐步逻辑回归模型来开发风险评分。
结果 共纳入359例患者，其中训练集217例，验证集142例，研究过程中未发生脱落。开发了1个24分的风险评分系统，感染风险在最低和最高评分的患者中分别为0.70%至99.60%。年龄、Killip分级、胰岛素使用、白细胞计数、血清白蛋白、利尿剂及经股动脉途径7个变量被纳入模型。该模型在开发和验证队列中均达到了同样高的区分度（C统计量：0.85），并在2个数据集中显示出良好的校准。在开发队列和验证队列中，心肌梗死后感染的发生率在风险评分组中稳步增加。此外，该风险评分在这些患者中对感染、住院全因死亡和主要不良心血管事件（MACE）表现出良好的预测能力。
结论 本研究建立了一种简单的床边工具用于评估接受PCI的STEMI患者发生感染及其他住院结果的风险评分系统。临床医生可以利用该风险评分系统评估感染风险，并据此做出基于证据的决策。
, authors=朱立杉
1, 高雯鑫
1, 李佳莹
1, 梁静
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朱立杉（1998-），女，主治医师，主要从事心肌梗死方面的临床工作和研究
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