Article(id=1291704999478845627, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1744473600000, receivedDateStr=2025-04-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896070593, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896070593, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896070593, creator=13701087609, updateTime=1785896070593, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2435, endPage=2440, ext={EN=ArticleExt(id=1291704999701143740, articleId=1291704999478845627, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of labetalol and nifedipine in patients with preeclampsia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To compare the clinical efficacy and safety of labetalol injection and nifedipine controlled-release tablets combined with magnesium sulfate injection and calcium carbonate D3 tablets in the treatment of preeclampsia.
Methods The patients with preeclampsia who were hospitalized in the obstetrics department of our hospital were included as the research objects, and the patients were divided into group A, group B and group C according to the medication plan. Group A was treated with labetalol hydrochloride injection 100-200 mg, intravenous drip, 1.5-3.5 mg per minute, once a day combined with 25% magnesium sulfate injection 60 mL, intravenous drip, 1.55-2.0 g per hour, 25 g per day and calcium carbonate D3 tablets, take orally, 300 mg each time, twice a day; Group B was treated with nifedipine controlled-release tablets orally, 30 mg each time, once a day, and the administration methods of magnesium sulfate injection, calcium carbonate D3 tablets were the same as those in group A; Group C was treated with labetalol hydrochloride injection, nifedipine controlled-release tablets, magnesium sulfate injection and calcium carbonate D3 tablets, and the administration methods of them were the same as those in group A and group B. The clinical efficacy, blood pressure condition, heart and kidney function, psychological status, fetal hemodynamics, maternal and pregnancy outcome of patients in 3 groups were compared, and the safety was evaluated.
Results A total of 170 patients were enrolled, 90 patients in group A, 39 patiets in group B and 41 patients in group C. After treatment, the total effective rates of group A, Group B and Group C were 58.89% (53 cases/90 cases), 53.85% (21 cases / 39 cases) and 85.37% (35 cases / 41 cases), respectively, and the blood pressure recovery time were 3.00 (3.00,5.00), 3.00 (3.00,5.00), and 7.00 (3.00,9.00) d, respectively. The total effective rate of group C was statistically significantly higher than that of group A and group B (all P<0.05), and the recovery time of blood pressure was statistically significantly shorter than that of group A and group B (all P<0.05). After treatment, the systolic blood pressures of group A, group B and group C were (145.60±5.15), (143.72±4.86) and (137.24±5.07) mmHg, respectively; the diastolic blood pressures were (97.83±6.56), (96.72±7.00) and (86.80±4.87) mmHg, respectively; Hamilton anxiety scale scores were 15.00 (13.00,17.00), 15.00 (13.50,17.50) and 12.00 (11.00,14.00) points, respectively; the Hamilton depression scale scores were 14.00 (12.00,15.00), 14.00 (12.00,15.00) and 10.00 (9.00,12.00) points, respectively; and the above indicators in group C were all lower than those of group A and group B (all P<0.05). After treatment, the B-type natriuretic peptide levels in group A, group B and group C were 35.00 (21.00,56.00), 42.00 (22.50,90.50) and 24.00 (13.00,60.00) pg·L-1, respectively; the the urinary protein levels were 0.35 (0.14,0.57), 0.24 (0.15, 0.39) and 0.14 (0.06,0.34) g, respectively; and the B-type natriuretic peptide level of group C was statistically significantly lower than that of group B (P<0.05), and the urinary protein level was statistically significantly lower than that of group A (P<0.05). After treatment, the diastolic flow velocity ratio in group A, Group B and group C were 2.15 (1.92, 2.24), 2.04 (1.86, 2.23), 2.16 (2.02, 2.25), respectively; the flow resistance index were 0.53 (0.48, 0.55), 0.51 (0.46, 0.56), 0.54 (0.51, 0.58), respectively; the flow pulse index were 0.77 (0.66, 0.83), 0.69 (0.63, 0.80), 0.77 (0.67, 0.81), respectively; the incidence rates of adverse drug reactions were 13.33% (12 cases / 90 cases), 12.82% (5 cases / 39 cases) and 12.20% (5 cases / 41 cases), respectively; and there were no statistically significant differences in the above indicators and pregnancy outcome among the three groups (all P>0.05).
Conclusion The therapy with labetalol, nifedipine, magnesium sulfate and calcium in PE is better, which can improve the blood pressure level, psychological status, heart and kidney function, maternal and infant outcomes, regulate fetal hemodynamics, and will not cause serious adverse reactions.
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目的 比较拉贝洛尔注射液和硝苯地平控释片分别联合硫酸镁注射液和碳酸钙D3片治疗子痫前期患者的临床效果和安全性。
方法 以本院产科住院的子痫前期患者纳入为研究对象，根据用药方案将患者分为A组、B组和C组。A组用盐酸拉贝洛尔注射液100～200 mg，静脉滴注，每分钟1.5～3.5 mg，每天1次；25%硫酸镁注射液60 mL，静脉滴注，每小时1.5～2.0 g，每天25 g；碳酸钙D3片，口服，每次300 mg，每日2次；B组口服硝苯地平控释片，每次30 mg，每日1次，硫酸镁注射液和碳酸钙D3片联合治疗，给药方式同A组；C组用盐酸拉贝洛尔注射液、硝苯地平控释片、硫酸镁注射液和碳酸钙D3片联合治疗，给药方式同A组与B组。比较3组患者的临床疗效、血压情况、心肾功能、心理状况、胎儿血流动力学及妊娠结局，并评价安全性。
结果 本研究共纳入170例，其中A组90例、B组39例、C组41例。治疗后，A组、B组和C组的总有效率分别为58.89%（53例/90例）、53.85%（21例/39例）和85.37%（35例/41例），血压恢复时间分别为3.00（3.00,5.00）、3.00（3.00,5.00）和7.00（3.00,9.00）d，C组临床疗效总有效率显著高于A组和B组（均P<0.05），血压恢复时间显著短于A组和B组（均P<0.05）。治疗后，A组、B组和C组的收缩压分别为（145.60±5.15）、（143.72±4.86）和（137.24±5.07）mmHg，舒张压分别为（97.83±6.56）、（96.72±7.00）和（86.80±4.87）mmHg，汉密尔顿焦虑量表评分分别为15.00（13.00,17.00）、15.00（13.50,17.50）和12.00（11.00,14.00）分，汉密尔顿抑郁量表评分分别为14.00（12.00,15.00）、14.00（12.00,15.00）和10.00（9.00,12.00）分，C组的上述指标均显著低于A组和B组（均P<0.05）。治疗后，A组、B组和C组的B型钠尿肽水平分别为35.00（21.00,56.00）、42.00（22.50,90.50）和24.00（13.00,60.00）pg·L-1，尿蛋白水平分别为0.35（0.14,0.57）、0.24（0.15，0.39）和0.14（0.06,0.34）g，C组的B型钠尿肽水平显著低于B组（P<0.05），尿蛋白水平显著低于A组（P<0.05）。治疗后，A组、B组和C组的舒张期流速比值分别为2.15（1.92,2.24）、2.04（1.86,2.23）和2.16（2.02,2.25），血流阻力指数分别为0.53（0.48,0.55）、0.51（0.46,0.56）和0.54（0.51,0.58），血流搏动指数分别为0.77（0.66,0.83）、0.69（0.63,0.80）和0.77（0.67,0.81），药物不良反应发生率分别为13.33%（12例/90例）、12.82%（5例/39例）和12.20%（5例/41例），3组的上述指标及妊娠结局比较在统计学上差异均无统计学意义（均P>0.05）。
结论 拉贝洛尔注射液、硝苯地平控释片、硫酸镁注射液和碳酸钙D3片联合治疗子痫前期疗效较好，能改善患者血压水平、心理状况、心肾功能及母婴结局、调节胎儿血流动力学，且不会引起较严重的药物不良反应。
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蔡海瑞（1983-），女，副主任医师，主要从事产科方面的临床工作和研究
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