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Article(id=1291704959188357719, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1751385600000, receivedDateStr=2025-07-02, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896060987, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896060987, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896060987, creator=13701087609, updateTime=1785896060987, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2833, endPage=2840, ext={EN=ArticleExt(id=1291704959410655832, articleId=1291704959188357719, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen, columnId=1291339025546211579, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Drug Evaluation and Administration, runingTitle=null, highlight=null, articleAbstract=
Objective

This systematic review and Meta-analysis compared the efficacy and safety of dexibuprofen with ibuprofen across diverse clinical settings.

Methods

A comprehensive literature search was performed across multiple databases (PubMed, Embase, Web of Science, Scopus, Cochrane Library, and CNKI) to identify all relevant clinical trials comparing dexibuprofen and ibuprofen. Statistical analyses were conducted using RevMan 5.4.

Results

A Meta-analysis incorporating 21 randomized controlled trials demonstrated that dexibuprofen showed no statistically significant differences in efficacy compared to ibuprofen at full-dose (RR=1.02, 95% CI: 0.99-1.05), 70% doses (RR=0.92, 95% CI: 0.72-1.17), or 50% doses (RR=0.99, 95% CI: 0.82-1.19). Subgroup analyses indicated comparable efficacy between dexibuprofen and ibuprofen for both adult analgesia (RR=1.09, 95% CI: 0.97-1.23) and pediatric antipyresis (RR=1.01, 95% CI: 0.98-1.04). Regarding safety, full-dose dexibuprofen showed a lower risk of adverse events compared to ibuprofen (RR=0.76, 95% CI: 0.58-1.00).

Conclusion

Dexibuprofen demonstrates comparable efficacy to ibuprofen, exhibits good dose-sparing characteristics in the fields of analgesia and antipyresis. Furthermore, it exhibits superior safety at equivalent doses, making it suitable for patient populations requiring reduced drug exposure or those at risk of gastrointestinal adverse reactions.

, authors=MENG JIN1, Yu-ming CHENG1, 2, Rui-jie ZHUO1, 2, Yan-ran DENG1, 2, Hui LIU1, Hui-jing ZHANG1, 2, Le MA1, 2, Cheng GAN3, Mu-ge CHELI4, Bei-bei XU1, authorsList=MENG JIN, Yu-ming CHENG, Rui-jie ZHUO, Yan-ran DENG, Hui LIU, Hui-jing ZHANG, Le MA, Cheng GAN, Mu-ge CHELI, Bei-bei XU, authorCompany=null, correspAuthors=Bei-bei XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704959817503321, articleId=1291704959188357719, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=一项右布洛芬和布洛芬的有效性和安全性的系统性评价和荟萃分析, columnId=1291339025730760957, journalTitle=中国临床药理学杂志, columnName=药物评价与管理, runingTitle=null, highlight=null, articleAbstract=
目的

本研究采用系统性评价与荟萃分析方法，综合评估右布洛芬与布洛芬在不同临床适应症中的有效性及安全性差异。

方法

系统检索PubMed、Embase、Web of Science、Scopus、Cochrane Library和中国知网（CNKI）数据库，纳入比较右布洛芬与布洛芬的临床试验，用RevMan 5.4软件进行统计分析。

结果

系统性评价结果表明，右布洛芬在成人和儿童患者中均表现出良好的镇痛退热效果和安全性。Meta分析共纳入21项临床随机对照研究，结果显示，等剂量右布洛芬（RR=1.02，95% CI: 0.99~1.05）、70%剂量（RR=0.92，95% CI:0.72~1.17）和50%剂量右布洛芬（RR=0.99，95% CI:0.82~1.19）与布洛芬在疗效上在统计学上差异无统计学意义。亚组分析显示右布洛芬在成人镇痛（RR=1.09，95% CI: 0.97~1.23）及儿童退热（RR=1.01，95% CI: 0.98~1.04）中疗效与布洛芬在统计学上差异无统计学意义。安全性方面，等剂量右布洛芬不良事件发生风险低于布洛芬（RR=0.76，95% CI: 0.58~1.00）。

结论

右布洛芬在疗效方面与布洛芬无显著差异比较，在统计学上差异无统计学意义，在镇痛与退热领域表现出良好的剂量节约特性，且在同等剂量下具备更优的安全性，适用于需降低药物暴露量或存在胃肠道药物不良反应风险的患者群体。

, authors=金梦1, 陈毓铭1, 2, 卓瑞洁1, 2, 邓嫣然1, 2, 刘徽1, 张惠静1, 2, 马乐1, 2, 甘承3, 澈力木格4, 许蓓蓓1, authorsList=金梦, 陈毓铭, 卓瑞洁, 邓嫣然, 刘徽, 张惠静, 马乐, 甘承, 澈力木格, 许蓓蓓, authorCompany=null, correspAuthors=许蓓蓓, authorNote=

金梦（1986-），女，工程师，主要从事医学信息学相关研究

, correspAuthorsNote=
许蓓蓓，副研究员，博士生导师 Tel: （010）82805903 E-mail:
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金梦（1986-），女，工程师，主要从事医学信息学相关研究

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金梦（1986-），女，工程师，主要从事医学信息学相关研究

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一项右布洛芬和布洛芬的有效性和安全性的系统性评价和荟萃分析
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金梦 1 , 陈毓铭 1, 2 , 卓瑞洁 1, 2 , 邓嫣然 1, 2 , 刘徽 1 , 张惠静 1, 2 , 马乐 1, 2 , 甘承 3 , 澈力木格 4 , 许蓓蓓 1
中国临床药理学杂志 | 药物评价与管理 2025,41(19): 2833-2840
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中国临床药理学杂志 |药物评价与管理 2025 , 41 (19) : 2833 -2840
一项右布洛芬和布洛芬的有效性和安全性的系统性评价和荟萃分析
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金梦1, 陈毓铭1, 2, 卓瑞洁1, 2, 邓嫣然1, 2, 刘徽1, 张惠静1, 2, 马乐1, 2, 甘承3, 澈力木格4, 许蓓蓓1
作者信息
  • 1.北京大学临床医学高等研究院 医学信息学中心，北京 100191，中国
  • 2.北京大学 公共卫生学院，北京 100191，中国
  • 3.中国医学科学院 协和医学院 整形外科医院瘢痕与创面治疗中心，北京 100144，中国
  • 4.内蒙古医科大学 民族医药创新中心，呼和浩特市 010110，中国
通讯作者:
许蓓蓓，副研究员，博士生导师 Tel: （010）82805903 E-mail:
作者简介:

金梦（1986-），女，工程师，主要从事医学信息学相关研究

A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen
MENG JIN1, Yu-ming CHENG1, 2, Rui-jie ZHUO1, 2, Yan-ran DENG1, 2, Hui LIU1, Hui-jing ZHANG1, 2, Le MA1, 2, Cheng GAN3, Mu-ge CHELI4, Bei-bei XU1
Affiliations
  • 1.Medical Informatics Center, Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China
  • 2.School of Public Health, Peking University, Beijing 100191, China
  • 3.Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing 100144, China
  • 4.Medical Innovation Center for Nationalities, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region 010110, China
出版时间: 2025-10-17 doi: 10.13699/j.cnki.1001-6821.2025.19.021
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摘要
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目的

本研究采用系统性评价与荟萃分析方法，综合评估右布洛芬与布洛芬在不同临床适应症中的有效性及安全性差异。

方法

系统检索PubMed、Embase、Web of Science、Scopus、Cochrane Library和中国知网（CNKI）数据库，纳入比较右布洛芬与布洛芬的临床试验，用RevMan 5.4软件进行统计分析。

结果

系统性评价结果表明，右布洛芬在成人和儿童患者中均表现出良好的镇痛退热效果和安全性。Meta分析共纳入21项临床随机对照研究，结果显示，等剂量右布洛芬（RR=1.02，95% CI: 0.99~1.05）、70%剂量（RR=0.92，95% CI:0.72~1.17）和50%剂量右布洛芬（RR=0.99，95% CI:0.82~1.19）与布洛芬在疗效上在统计学上差异无统计学意义。亚组分析显示右布洛芬在成人镇痛（RR=1.09，95% CI: 0.97~1.23）及儿童退热（RR=1.01，95% CI: 0.98~1.04）中疗效与布洛芬在统计学上差异无统计学意义。安全性方面，等剂量右布洛芬不良事件发生风险低于布洛芬（RR=0.76，95% CI: 0.58~1.00）。

结论

右布洛芬在疗效方面与布洛芬无显著差异比较，在统计学上差异无统计学意义，在镇痛与退热领域表现出良好的剂量节约特性，且在同等剂量下具备更优的安全性，适用于需降低药物暴露量或存在胃肠道药物不良反应风险的患者群体。

右布洛芬  /  布洛芬  /  荟萃分析  /  有效性研究  /  安全性研究
Objective

This systematic review and Meta-analysis compared the efficacy and safety of dexibuprofen with ibuprofen across diverse clinical settings.

Methods

A comprehensive literature search was performed across multiple databases (PubMed, Embase, Web of Science, Scopus, Cochrane Library, and CNKI) to identify all relevant clinical trials comparing dexibuprofen and ibuprofen. Statistical analyses were conducted using RevMan 5.4.

Results

A Meta-analysis incorporating 21 randomized controlled trials demonstrated that dexibuprofen showed no statistically significant differences in efficacy compared to ibuprofen at full-dose (RR=1.02, 95% CI: 0.99-1.05), 70% doses (RR=0.92, 95% CI: 0.72-1.17), or 50% doses (RR=0.99, 95% CI: 0.82-1.19). Subgroup analyses indicated comparable efficacy between dexibuprofen and ibuprofen for both adult analgesia (RR=1.09, 95% CI: 0.97-1.23) and pediatric antipyresis (RR=1.01, 95% CI: 0.98-1.04). Regarding safety, full-dose dexibuprofen showed a lower risk of adverse events compared to ibuprofen (RR=0.76, 95% CI: 0.58-1.00).

Conclusion

Dexibuprofen demonstrates comparable efficacy to ibuprofen, exhibits good dose-sparing characteristics in the fields of analgesia and antipyresis. Furthermore, it exhibits superior safety at equivalent doses, making it suitable for patient populations requiring reduced drug exposure or those at risk of gastrointestinal adverse reactions.

dexibuprofen  /  ibuprofen  /  Meta-analysis  /  efficacy  /  safety
金梦, 陈毓铭, 卓瑞洁, 邓嫣然, 刘徽, 张惠静, 马乐, 甘承, 澈力木格, 许蓓蓓. 一项右布洛芬和布洛芬的有效性和安全性的系统性评价和荟萃分析. 中国临床药理学杂志, 2025 , 41 (19) : 2833 -2840 . DOI: 10.13699/j.cnki.1001-6821.2025.19.021
MENG JIN, Yu-ming CHENG, Rui-jie ZHUO, Yan-ran DENG, Hui LIU, Hui-jing ZHANG, Le MA, Cheng GAN, Mu-ge CHELI, Bei-bei XU. A systematic review and Meta-analysis of comparison of efficacy and safety between dexibuprofen and ibuprofen[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (19) : 2833 -2840 . DOI: 10.13699/j.cnki.1001-6821.2025.19.021

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doi: 10.13699/j.cnki.1001-6821.2025.19.021
  • 接收时间：2025-07-02
  • 首发时间：2026-08-05
  • 出版时间：2025-10-17
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  • 收稿日期：2025-07-02
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作者信息
    1.北京大学临床医学高等研究院 医学信息学中心，北京 100191，中国
    2.北京大学 公共卫生学院，北京 100191，中国
    3.中国医学科学院 协和医学院 整形外科医院瘢痕与创面治疗中心，北京 100144，中国
    4.内蒙古医科大学 民族医药创新中心，呼和浩特市 010110，中国

通讯作者:

许蓓蓓，副研究员，博士生导师 Tel: （010）82805903 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.19.021
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2种不同金属材料的力学参数
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Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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