Article(id=1291704914783260834, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.18.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733414400000, receivedDateStr=2024-12-06, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896050400, onlineDateStr=2026-08-05, pubDate=1758988800000, pubDateStr=2025-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896050400, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896050400, creator=13701087609, updateTime=1785896050400, updator=13701087609, issue=Issue{id=1291704811443999077, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='18', pageStart='2551', pageEnd='2700', issueExtLink='null', onlineDate='null', pubDate='1758988800000', pubDateStr='2025-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896025763, creator='13701087609', updateTime=1785896871490, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708358743053253, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708358743053254, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704811443999077, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2674, endPage=2678, ext={EN=ArticleExt(id=1291704914976198819, articleId=1291704914783260834, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=MAPK signaling pathway regulates chronic obstructive pulmonary disease and the intervention effects of traditional Chinese medicine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent airflow limitation. Its pathogenesis is complex and involves multiple pathological processes such as oxidative stress, inflammatory response and apoptosis. The mitogen-activated protein kinase (MAPK) signaling pathway plays a significant role in regulating cell growth, proliferation, differentiation and apoptosis. Modern research has confirmed that traditional Chinese medicine can exert therapeutic effects on COPD by intervening in the MAPK signaling pathway. This article reviews the regulatory mechanism of the MAPK signaling pathway on COPD and the intervention effect of traditional Chinese medicine on COPD in recent years, aiming to provide research basis for the development of new traditional Chinese medicine and the clinical application of traditional Chinese medicine in the treatment of COPD.

, authors=Xin-ying LIU^1a, Fang FANG^1a, Yuan-yuan GU^1b, Yan-li MENG², Yu-yan GUO^1c, Jun ZUO^1a, Yu LONG^1a, Yuan-qi GUO^1a, authorsList=Xin-ying LIU, Fang FANG, Yuan-yuan GU, Yan-li MENG, Yu-yan GUO, Jun ZUO, Yu LONG, Yuan-qi GUO, authorCompany=null, correspAuthors=Fang FANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704915374657700, articleId=1291704914783260834, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=MAPK信号通路调控慢性阻塞性肺疾病及中药干预作用, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

慢性阻塞性肺疾病（COPD）是一种以持续性气流受限为特征的慢性炎症性疾病，其发病机制复杂，涉及氧化应激、炎症反应和细胞凋亡等多种病理过程。丝裂原活化蛋白激酶（MAPK）信号通路在调控细胞的生长、增殖、分化和凋亡等方面发挥重要作用，现代研究证实中药可通过干预MAPK信号通路发挥治疗COPD的作用。本文就近年来MAPK信号通路对COPD的调控机制及中药对COPD的干预作用进行综述，旨在为开发中药新药以及临床应用中药治疗COPD提供研究依据。

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刘新颖（1998-），女，硕士研究生，主要从事中医药作用机制研究

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刘新颖（1998-），女，硕士研究生，主要从事中医药作用机制研究

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