Article(id=1291704912031806244, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749052800000, receivedDateStr=2025-06-05, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896049744, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896049744, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896049744, creator=13701087609, updateTime=1785896049744, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2817, endPage=2821, ext={EN=ArticleExt(id=1291704912711283493, articleId=1291704912031806244, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the regulatory role of microRNA in vascular endothelial cells and its involvement in venous thrombosis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

As a crucial type of non-coding ribonucleic acid (RNA), microRNA (miRNA) is widely involved in various biological processes such as cell proliferation, differentiation, and apoptosis. In recent years, increasing attention has been paid to the regulatory role of miRNAs in vascular endothelial cells, particularly their potential impact on the pathological state of venous thrombosis. Studies have shown that miRNAs may play a key role in the occurrence and development of venous thrombosis by regulating the functions of vascular endothelial cells. However, the specific mechanisms underlying the role of miRNAs in this process remain incompletely understood, and clinical applications face numerous challenges. This review aims to summarize the regulatory mechanisms of miRNAs in vascular endothelial cells and research progress in venous thrombosis, explore their prospects as potential therapeutic targets, and outline current research challenges and future directions, thereby providing new insights into the role of miRNAs in venous thrombosis.

, authors=Tao LIU¹, Yu-biao GU¹, Hui-qing TIAN², Lei ZHANG¹, Ning-bo LEI¹, Bi-hui BAI¹, authorsList=Tao LIU, Yu-biao GU, Hui-qing TIAN, Lei ZHANG, Ning-bo LEI, Bi-hui BAI, authorCompany=null, correspAuthors=Yu-biao GU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704913168462630, articleId=1291704912031806244, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=微小核糖核酸在血管内皮细胞中的调控作用及其在静脉血栓形成中的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

微小核糖核酸（miRNA）作为一种重要的非编码核糖核酸（RNA），广泛参与细胞增殖、分化和凋亡等多种生物过程。近年来，miRNA在血管内皮细胞中的调控作用受到越来越多的关注，尤其是在静脉血栓形成这一病理状态下的潜在影响。研究表明，miRNA通过调控血管内皮细胞的功能，可能在静脉血栓的发生和发展中发挥关键作用。然而，目前关于miRNA在这一过程中的具体机制仍不完全清晰，且在临床应用方面也面临诸多挑战。本文旨在综述miRNA在血管内皮细胞中的调控机制及其在静脉血栓形成中的研究进展，探讨其作为潜在治疗靶点的前景，并总结当前研究中的挑战与未来研究方向，以期为深入理解miRNA在静脉血栓形成中的作用提供新的视角。

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刘涛（1990-），男，主治医师，主要从事足踝及矫形研究

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刘涛（1990-），男，主治医师，主要从事足踝及矫形研究

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