中国临床药理学杂志

环泊酚联合阿芬太尼抑制老年胃镜进镜反应半数有效量的研究

PDF下载

熊逸群 ¹ , 潘浩威 ² , 万海方 ³

中国临床药理学杂志 | 临床与基础桥接研究 2025,41(19): 2754-2759

收起

中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (19) : 2754 -2759

环泊酚联合阿芬太尼抑制老年胃镜进镜反应半数有效量的研究

全屏

[Author(id=1291704909880119401, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704909976588395, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704909880119401, language=EN, stringName=Yi-qun XIONG, firstName=Yi-qun, middleName=null, lastName=XIONG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704910047891564, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704909880119401, language=CN, stringName=熊逸群, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.浙江中医药大学第二临床学院，浙江杭州 310000, bio={"content":"

熊逸群（1999-），男，硕士研究生在读，主要从事临床麻醉有关工作及研究

"}, bioImg=null, bioContent=

熊逸群（1999-），男，硕士研究生在读，主要从事临床麻醉有关工作及研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704909557157983, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, xref=1., ext=[AuthorCompanyExt(id=1291704909565546592, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909557157983, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China), AuthorCompanyExt(id=1291704909582323809, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909557157983, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.浙江中医药大学第二临床学院，浙江杭州 310000)])]), Author(id=1291704910127583342, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291704910215663728, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704910127583342, language=EN, stringName=Hao-wei PAN, firstName=Hao-wei, middleName=null, lastName=PAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Department of Anesthesiology, Wenzhou People’s Hospital, Wenzhou 325041, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704910307938417, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704910127583342, language=CN, stringName=潘浩威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.温州市人民医院麻醉科，浙江温州 325041, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704909657821282, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, xref=2., ext=[AuthorCompanyExt(id=1291704909666209891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909657821282, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Department of Anesthesiology, Wenzhou People’s Hospital, Wenzhou 325041, Zhejiang Province, China), AuthorCompanyExt(id=1291704909674598500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909657821282, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.温州市人民医院麻醉科，浙江温州 325041)])]), Author(id=1291704910383435891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yb2218204@zju.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291704910471516277, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704910383435891, language=EN, stringName=Hai-fang WAN, firstName=Hai-fang, middleName=null, lastName=WAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.Anesthesiology and Operation Center, Hangzhou Red Cross Hospital, Hangzhou 310000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291704910551208054, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, authorId=1291704910383435891, language=CN, stringName=万海方, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=³, address=^3.杭州红十字会医院麻醉手术中心，浙江杭州 310000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291704909750095973, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, xref=3., ext=[AuthorCompanyExt(id=1291704909762678886, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909750095973, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.Anesthesiology and Operation Center, Hangzhou Red Cross Hospital, Hangzhou 310000, Zhejiang Province, China), AuthorCompanyExt(id=1291704909775261799, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291704908340809820, companyId=1291704909750095973, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.杭州红十字会医院麻醉手术中心，浙江杭州 310000)])])]

熊逸群¹, 潘浩威², 万海方³

作者信息

^1.浙江中医药大学第二临床学院，浙江杭州 310000

^2.温州市人民医院麻醉科，浙江温州 325041

^3.杭州红十字会医院麻醉手术中心，浙江杭州 310000

通讯作者:

万海方，主任医师，硕士生导师 MP: 15968871660 E-mail: yb2218204@zju.edu.cn

作者简介:

熊逸群（1999-），男，硕士研究生在读，主要从事临床麻醉有关工作及研究

The research of the median effective dose of ciprofol combined with alfentanil to inhibit responses to gastroscopy in elderly patients

Yi-qun XIONG¹, Hao-wei PAN², Hai-fang WAN³

Affiliations

^1.The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China

^2.Department of Anesthesiology, Wenzhou People’s Hospital, Wenzhou 325041, Zhejiang Province, China

^3.Anesthesiology and Operation Center, Hangzhou Red Cross Hospital, Hangzhou 310000, Zhejiang Province, China

出版时间: 2025-10-17 doi: 10.13699/j.cnki.1001-6821.2025.19.010

文章导航

摘要

收起

目的

探讨复合阿芬太尼时环泊酚抑制老年患者胃镜检查进镜反应的半数有效剂量（ED₅₀）。

方法

选择择期无痛胃镜检查老年患者115例，将拟行胃肠镜检查术的患者按年龄性别分为四组：A组为65~74岁男性，B组为65~74岁女性，C组为75~85岁男性，D组为75~85岁女性。静脉注射阿芬太尼4.00 ug·kg^-1后予环泊酚，初始剂量为0.30 mg·kg^-1，推注时间大于30s。依据改良Dixon序贯试验法，相邻患者浓度差设为0.03 mg·kg^-1。采用概率单位（Probit）概率回归分析法计算四组老年患者进镜反应的ED₅₀、95%有效剂量（ED₉₅）及其95%置信区间（CI）并记录各组生命体征，并进行统计分析。

结果

A、B、C及D组的环泊酚用量的ED₅₀及其CI分别为：0.19（0.17~0.21）、0.20（0.18~0.22）、0.15（0.12~0.18）及0.17（0.15~0.19）mg·kg^-1。ED₉₅及其95%CI分别为：A组0.23（0.09~0.32）mg·kg^-1、B组0.25（0.23~0.30）mg·kg^-1、C组0.20（0.18~0.38）mg·kg^-1、D组0.21（0.19~0.31）mg·kg^-1。同年龄段不同性别老年患者的环泊酚ED₅₀在统计学上差异无统计学意义（P>0.05），同性别的75~85岁患者环泊酚ED₅₀小于65~74岁患者（P<0.05），在统计学上差异有统计学意义。Hosmer-Lemeshow检验显示四组Probit模型均拟合良好（P>0.05）。

结论

A、B、C及D组的环泊酚复合4.00 ug·kg^-1阿芬太尼抑制老年患者无痛胃镜检查时进镜反应的ED₅₀及其95%CI分别为：0.19（0.17~0.21）、0.20（0.18~0.22）、0.15（0.12~0.18）及0.17（0.15~0.19）mg·kg^-1。需根据年龄分层调整环泊酚剂量以减少不良反应，为临床合理使用提供依据。

关键词

环泊酚 / 老年患者 / 内镜检查 / 半数有效量

Abstract

收起

Objective

To investigate the median effective dose (ED₅₀) of ciprofol combined with alfentanil inhibiting responses to gastroscopy in geriatric patients.

Methods

A total of 115 elderly patients scheduled for elective painless gastroscopy were enrolled in this study. Patients scheduled for gastroscopy were divided into four groups according to age and gender: Group A consisted of males aged 65-74 years, Group B consisted of females aged 65-74 years, Group C consisted of males aged 75-85 years, and Group D consisted of females aged 75-85 years. Based on the modified Dixon sequential test method, intravenous alfentanil 4 ug·kg^-1 was administered followed by ciprofol, with an initial dose of 0.3 mg·kg^-1 and the injection time was longer than 30 s, and the dose gradient was set at 0.03 mg·kg^-1. The ED₅₀, 95% effective dose (ED₉₅), and their 95% confidence intervals (CIs) for gastroscopic response in the four patient groups were calculated using probit regression analysis. Additionally, vital signs were documented for all groups.

Results

The calculated ED₅₀ and its 95% CI for the dosage of ciprofol in the four groups of elderly patients were 0.19 (0.17-0.21) mg·kg^-1 in group A, 0.20 (0.18-0.22) mg·kg^-1 in group B, 0.15 (0.12-0.18) mg·kg^-1 in group C, 0.17(0.15-0.19) mg·kg^-1 in group D. The ED₉₅ and its 95% CI were 0.23 (0.09-0.32) mg·kg^-1 for Group A, 0.25 (0.23-0.30) mg·kg^-1 for Group B, 0.20 (0.18-0.38) mg·kg^-1 for Group C, and 0.21 (0.19-0.31) mg·kg^-1 for Group D. There was no statistically significant difference in the ED₅₀ of ciprofol between genders within the same age group (P>0.05). However, the ED₅₀ of ciprofol in patients aged 75-85 was significantly lower than that in patients aged 65-74 of the same gender (P<0.05). The Hosmer-Lemeshow test indicated that the Probit models for all four groups fitted well (P>0.05).

Conclusion

The ED₅₀ and its 95% CI for the inhibition of the entry response during painless gastroscopy in elderly patients by ciprofol combined with 4.00 ug·kg^-1 alfentanil were 0.19 (0.17-0.21) mg·kg^-1 in group A, 0.20 (0.18-0.22) mg·kg^-1 in group B, 0.15 (0.12-0.18) mg·kg^-1 in group C, 0.17(0.15-0.19) mg·kg^-1 in group D. Age-stratified dosage adjustment of ciprofol is necessary to minimize adverse reactions.

Key words

ciprofol / geriatric patients / endoscopic procedures / median effective dose (ED₅₀)

引用本文

熊逸群, 潘浩威, 万海方. 环泊酚联合阿芬太尼抑制老年胃镜进镜反应半数有效量的研究. 中国临床药理学杂志, 2025 , 41 (19) : 2754 -2759 . DOI: 10.13699/j.cnki.1001-6821.2025.19.010

Yi-qun XIONG, Hao-wei PAN, Hai-fang WAN. The research of the median effective dose of ciprofol combined with alfentanil to inhibit responses to gastroscopy in elderly patients[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (19) : 2754 -2759 . DOI: 10.13699/j.cnki.1001-6821.2025.19.010

基金

收起

浙江省杭州市生物医药和健康产业发展扶持科技专项(2022WJC111)

参考文献

收起

文献

收起

参考文献引证文献

排序方式：

2025年第41卷第19期

PDF下载

136

引用本文

BibTeX

文章信息

doi: 10.13699/j.cnki.1001-6821.2025.19.010

接收时间：2025-06-09
首发时间：2026-08-05
出版时间：2025-10-17

补充材料

相关文章

文章信息

作者

出版历史

收稿日期：2025-06-09

基金

浙江省杭州市生物医药和健康产业发展扶持科技专项(2022WJC111)

作者信息

^1.浙江中医药大学第二临床学院，浙江杭州 310000

^2.温州市人民医院麻醉科，浙江温州 325041

^3.杭州红十字会医院麻醉手术中心，浙江杭州 310000

通讯作者:

万海方，主任医师，硕士生导师 MP: 15968871660 E-mail: yb2218204@zju.edu.cn

参考文献

分享链接

https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.19.010

分享至

全文二维码

扫描看全文

引用本文

BibTeX

本文的引用情况

2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

关闭全屏

BibTeX
EndNote
RefWorks
TxT