Article(id=1291704904691774181, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1738512000000, receivedDateStr=2025-02-03, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896047994, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896047994, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896047994, creator=13701087609, updateTime=1785896047994, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2418, endPage=2422, ext={EN=ArticleExt(id=1291704904905683686, articleId=1291704904691774181, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of empagliflozin in the treatment of heart failure patients with mildly reduced ejection fraction, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the effects of empagliflozin tablets-assisted therapy on end-diastolic volume and major cardiovascular adverse events in patients with mild reduced EF heart failure (HFmrEF).
Methods Patients with HFmrEF were divided into control group and treatment group by queue method. The control group received conventional treatment. The treatment group was given empagliflozin tablets in addition to control group, 10 mg each time (starting dose and target dose were both 10 mg), orally on an empty stomach in the morning, once a day. Both groups of patients were treated for 6 months. The clinical efficacy, end-diastolic volume including left ventricular end-diastolic area (LVEDA) and left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), myocardial markers including cardiac troponin I (cTnI) and N-terminal B-type natriuretic peptide (NT-proBNP), major adverse cardiovascular events and safety were compared between the two groups.
Results Both groups had no cases dropped out, with 60 cases in control group and 60 cases in treatment group. After treatment, the total effective rates of treatment group and control group were 95.00% (57 cases/60 cases) and 81.67% (49 cases/60 cases), respectively, with statistically significant difference (P<0.05). After treatment, the LVEF of treatment group and control group were (56.20±5.12)% and (50.25±4.26)%, LVEDV were (142.58±15.58) and (165.28±18.59) mL, LVEDA were (36.28±3.41) and (39.62±3.56) cm2, serum NT-proBNP levels were (869.48±135.29) and (1 459.87±158.69) pg·mL-1, cTnI levels were (7.02±1.65) and (9.28±1.74) ng·L-1, respectively, and the incidence of major cardiovascular adverse events in treatment group and control group were 5.00% and 16.67%. The above indexes in treatment group had statistical significant differences compared with control group (all P<0.05). The adverse drug reactions of treatment group mainly include headache, hyperkalemia, hypotension and gastrointestinal reactions, while the adverse drug reactions of control group mainly include hyperkalemia, headache and hypotension. During the treatment, the incidence of adverse drug reactions in treatment group and control group were 8.33% and 5.00%, respectively (P>0.05).
Conclusion Adjuvant treatment with empagliflozin tablets can improve the overall therapeutic effect of HFmrEF, improve the end diastolic volume index and LVEF of patients, regulate myocardial marker indicators, reduce the incidence of major cardiovascular adverse events, and has good safety.
, authors=Guo-biao LI, Cai-yun WU, Zi-qing GONG, authorsList=Guo-biao LI, Cai-yun WU, Zi-qing GONG, authorCompany=null, correspAuthors=Guo-biao LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704905295753959, articleId=1291704904691774181, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=恩格列净治疗射血分数轻度降低心力衰竭患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察恩格列净片治疗射血分数轻度降低心力衰竭（HFmrEF）患者的临床疗效及安全性。
方法 将HFmrEF患者按队列法分为对照组和试验组。对照组给予常规治疗；试验组在对照组治疗的基础上，予恩格列净片，常规剂量为每次10 mg，每天1次（起始剂量和维持剂量相同）。2组患者均治疗6个月。比较2组患者的临床疗效，包括左心室舒张末期面积（LVEDA）和左心室舒张末期容积（LVEDV）在内的舒张末容积，左心室射血分数（LVEF），包括心肌肌钙蛋白Ⅰ（cTnⅠ）和N末端B型利钠肽原（NT-proBNP）在内的心肌标志物指标，主要心血管不良事件发生情况，并进行安全性评价。
结果 试验组和对照组均无病例脱落，对照组入组60例，试验组入组60例。治疗后，试验组和对照组的总有效率分别为95.00%（57例/60例）和81.67%（49例/60例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的LVEF分别为（56.20±5.12）%和（50.25±4.26）%，LVEDV分别为（142.58±15.58）和（165.28±18.59）mL，LVEDA分别为（36.28±3.41）和（39.62±3.56）cm2，血清NT-proBNP水平分别为（869.48±135.29）和（1 459.87±158.69）pg·mL-1，cTnⅠ水平分别为（7.02±1.65）和（9.08±1.74）ng·L-1，试验组和对照组的上述指标比较，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的主要心血管不良事件发生率分别为5.00%和16.67%，在统计学上差异有统计学意义（P<0.05）。试验组的药物不良反应主要有头痛、高钾血症、低血压、胃肠道反应，对照组的药物不良反应主要有高钾血症、头痛、低血压。试验组和对照组的药物不良反应总发生率分别为8.33%和5.00%，在统计学上差异无统计学意义（P>0.05）。
结论 恩格列净片治疗HFmrEF患者的临床疗效显著，其能显著改善患者的舒张末容积指数及LVEF，调节心肌标志物指标，降低主要心血管不良事件发生率，且不增加药物不良反应的发生率。
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李国彪（1982-），男，副主任医师，主要从事心内科相关的临床诊疗工作和研究
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