Article(id=1291704904347836841, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.19.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1740240000000, receivedDateStr=2025-02-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896047913, onlineDateStr=2026-08-05, pubDate=1760630400000, pubDateStr=2025-10-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896047913, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896047913, creator=13701087609, updateTime=1785896047913, updator=13701087609, issue=Issue{id=1291704892859638107, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='19', pageStart='2701', pageEnd='2850', issueExtLink='null', onlineDate='null', pubDate='1760630400000', pubDateStr='2025-10-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896045171, creator='13701087609', updateTime=1785896787712, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708007352656266, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708007352656267, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704892859638107, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2810, endPage=2816, ext={EN=ArticleExt(id=1291704904591106474, articleId=1291704904347836841, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Simultaneous determination of fluconazole, Posaconazole, and Linezolid in human cerebrospinal fluid by HPLC MS/MS, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To establish a high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) method for the simultaneous determination of fluconazole, posaconazole, and linezolid in human cerebrospinal fluid.
Methods Cerebrospinal fluid samples were precipitated with acetonitrile containing internal standard (voriconazole) and separated by Agilent C18 column (2.7 μm, 4.6×150 mm). The mobile phase was 0.1% formic acid aqueous solution acetonitrile, gradient elution, flow rate 0.4 mL·min-1, column temperature 35 ℃, and injection volume 1μL; The spray ion source, positive ion mode and multi reaction monitoring were used for the determination. The specificity, standard curve, lowerer limit of quantification(LLOQ), precision, accuracy, recovery rate and recovery rate. This method was applied to determine the concentrations of fluconazole, posaconazole, and linezolid in clinical cerebrospinal fluid.
Results The methodological results showed that fluconazole (0.4-32 μg·mL-1, r=0.999 6) in cerebrospinal fluid samples, posaconazole (0.04-3.2 μg·mL-1, r=0.9992) and linezolid (0.2-16 μg·mL-1, r=0.9989) had a good linear relationship and specificity within the linear range. The LLOQ of, posaconazole, and linezolid was 0.4、0.04 and 0.2 μg·mL-1, respectively. The relative standard deviation (RSD) values of intra-day and inter-day precision were both less than 15%, with good stability and extraction recovery rates above 80%, unaffected by matrix effects. Additionally, the method exhibited good detection sensitivity for fluconazole, posaconazole, and linezolid in the cerebrospinal fluid of rats and clinical patients. The concentration of the 7 tested sample was within the linear range.
Conclusion This method is simple, fast, and highly sensitive, and can be used for the determination of cerebrospinal fluid concentrations of fluconazole, posaconazole, and linezolid in clinical patients.
, authors=Qiong QIANG, Qin-hui WANG, Yan YANG, Xi CHEN, Wei JIANG, authorsList=Qiong QIANG, Qin-hui WANG, Yan YANG, Xi CHEN, Wei JIANG, authorCompany=null, correspAuthors=Wei JIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704905169920427, articleId=1291704904347836841, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=HPLC-MS/MS法同时测定脑脊液中氟康唑、泊沙康唑、利奈唑胺的浓度, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立一种同时测定脑脊液中氟康唑、泊沙康唑、利奈唑胺浓度的高效液相色谱-质谱（HPLC-MS/MS）方法。
方法 脑脊液样品经乙腈沉淀蛋白后，通过Agilent C18柱（2.7 μm，4.6×150 mm）分离，采用水（0.1%甲酸）-乙腈流动相梯度洗脱，洗脱流速0.4 mL·min-1，柱温35 ℃，进样量1 μL；采用电喷雾离子源正离子模式，多反应监测进行测定。考察该方法的专属性、标准曲线与定量下限、精密度与准确度、稳定性和回收率。采用上述方法测定临床脑脊液标本中氟康唑、泊沙康唑、利奈唑胺的药物浓度。
结果 方法学结果显示专属性良好，三种药物的定量下限分别为0.4、0.04和0.2 μg·mL-1，脑脊液样本中氟康唑（0.4～32 μg·mL-1，r=0.9996），泊沙康唑（0.04～3.2 μg·mL-1，r=0.9992）和利奈唑胺（0.2～16 μg·mL-1，r=0.9989）在线性范围内线性关系良好。日内、日间精密度的相对标准偏差（RSD）值都<15%，稳定性良好，提取回收率均在80%以上，不受基质效应影响。该方法对7例临床患者脑脊液中氟康唑、泊沙康唑、利奈唑胺具有良好的检测灵敏度，测得样本浓度在线性范围内。
结论 本方法简单、快速、灵敏度高、专属性强，可用于临床样本的大量测定。
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强琼（1993-），女，主管药师，主要从事临床精准用药监测
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