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Sodium-glucose cotransporter 2 (SGLT2) inhibitors, as a new class of oral antidiabetic drugs, have gained attention in the cardiovascular and metabolic fields due to their non-dependent hypoglycemic effects and cardioprotective effects. Studies have confirmed that these drugs protect myocardial cells by reconstructing the mitochondrial metabolic network in cardiomyocytes. They are widely used in patients with cardiovascular diseases and show significant efficacy. This article integrates recent research findings, systematically reviewing the mechanisms of myocardial cell protection under multidimensional regulation of mitochondrial metabolism by SGLT2 inhibitors. It expands the theoretical support for their use in cardiovascular therapy and provides references for related research directions.

, authors=Yuan-hao LONG¹, Guo-liang ZOU², authorsList=Yuan-hao LONG, Guo-liang ZOU, authorCompany=null, correspAuthors=Guo-liang ZOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704863390458083, articleId=1291704862127972577, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=SGLT2抑制剂调控线粒体稳态保护心肌细胞的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

钠－葡萄糖协同转运蛋白2（SGLT2）抑制剂作为新型口服降糖药物，其非依赖降糖作用的心脏保护效应已成为心血管代谢领域的研究热点，研究证实该类药物通过重构心肌细胞线粒体代谢网络发挥对心肌细胞的保护作用，并被广泛应用于心血管疾病患者，且疗效显著。本文整合了近年来研究成果，系统综述了SGLT2抑制剂对心肌细胞线粒体多维度调控下的心肌细胞保护机制，拓展了其在心血管治疗方面的理论支撑，并为相关研究方向提供参考。

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龙元昊（1999-），男，硕士研究生，从事中西医结合心血管疾病方面的研究

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龙元昊（1999-），男，硕士研究生，从事中西医结合心血管疾病方面的研究

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