Article(id=1291704852787261710, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.00.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1749744000000, receivedDateStr=2025-06-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896035619, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896035619, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896035619, creator=13701087609, updateTime=1785896035619, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2955, endPage=2961, ext={EN=ArticleExt(id=1291704852988588303, articleId=1291704852787261710, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on the prevention and treatment of cerebral ischemia and related diseases by apigenin, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Cerebral ischemia is a common neurological disease worldwide, with complex pathophysiological mechanisms, which seriously affects the quality of life of patients after the onset of the disease. Currently, cerebral ischemia is mainly treated with drugs and surgery, and its lethality and disability rate are still at a high level due to the limitation of time window and neurological irreversibility. Therefore, finding a safe and effective drug is crucial for the treatment of cerebral ischaemia. apigenin is a naturally occurring flavonoid with a variety of biological activities, such as combating oxidative stress, anti-inflammatory and neuroprotective effects. In recent years, an increasing number of studies have demonstrated the potential therapeutic role of apigenin in cerebral ischaemia. This paper describes the mechanisms of apigenin in preventing and treating cerebral ischaemia, including anti-oxidative stress, attenuating neuroinflammation, regulating apoptosis and promoting neuroregeneration. In addition, this paper discusses the prospects and challenges for the clinical application of apigenin in the treatment of cerebral ischaemia.

, authors=Qian-qian LIU^{1, 2}, Ke WANG³, Yue WANG^{1, 2}, Huai-yu LIU^{1, 2}, Ping LAN^{1, 2}, Shuang ZHANG^{1, 2}, Zhi HE^{1, 2, 3}, authorsList=Qian-qian LIU, Ke WANG, Yue WANG, Huai-yu LIU, Ping LAN, Shuang ZHANG, Zhi HE, authorCompany=null, correspAuthors=Zhi HE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704853374464272, articleId=1291704852787261710, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=芹菜素防治脑缺血及相关疾病的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

脑缺血是世界范围内常见的神经系统疾病，其病理生理机制复杂，发病后严重影响着患者的生活质量。当前脑缺血以药物及手术治疗为主，因受限于时间窗及神经损伤的不可逆性，导致其致死率和致残率仍处于较高水平。因此，寻找一种安全有效的药物对脑缺血的治疗至关重要。芹菜素是一种天然黄酮类化合物，具有多种生物活性，包括抗氧化、抗炎和抗肿瘤作用。近年来，越来越多的研究表明芹菜素在脑缺血中具有潜在的治疗作用。本文阐述了芹菜素预防及治疗脑缺血的机制，包括抗氧化应激、减轻神经炎症、调节细胞凋亡和促进神经再生等方面。此外，本文还探讨了芹菜素在脑缺血治疗中的临床应用前景及面临的挑战。

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刘倩倩（1997-），女，硕士研究生，主要从事脑血管疾病的研究

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刘倩倩（1997-），女，硕士研究生，主要从事脑血管疾病的研究

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