Article(id=1291704824354066878, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.20.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1752508800000, receivedDateStr=2025-07-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896028840, onlineDateStr=2026-08-05, pubDate=1761580800000, pubDateStr=2025-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896028840, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896028840, creator=13701087609, updateTime=1785896028840, updator=13701087609, issue=Issue{id=1291704786705993936, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='20', pageStart='2851', pageEnd='3000', issueExtLink='null', onlineDate='null', pubDate='1761580800000', pubDateStr='2025-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896019864, creator='13701087609', updateTime=1785896741492, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291707813508702571, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291707813508702572, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704786705993936, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2969, endPage=2975, ext={EN=ArticleExt(id=1291704824584753599, articleId=1291704824354066878, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Recent advances in clinical monitoring instrumental analysis and of benzodiazepine sedative-hypnotics, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

In recent years, there has been an increasing trend in poisoning cases caused by improper use of sedative-hypnotic drugs, with related fatalities also rising annually. The dual characteristics of significant therapeutic effects and abuse potential have made these drugs a critical issue in global public health and clinical diagnosis and treatment. As a classic category of sedative-hypnotic agents, benzodiazepines are widely used in clinical departments such as emergency medicine, psychiatry, and cardiology. However, long-term use may lead to drug accumulation, tolerance, and dependence risks. Due to increasing social stress and accelerated population aging, the illicit use and recreational abuse of benzodiazepines persist. A growing number of individuals attempt to use these drugs to improve sleep quality or seek psychological euphoria, resulting in a significant rise in abuse and poisoning risks. This article outlines the monitoring requirements for benzodiazepines in clinical medication, introduces the latest sample pretreatment techniques, and reviews the current commonly used analytical technology systems, including the development trends of chromatography, mass spectrometry, and their hyphenated techniques. It focuses on the application value of different detection technologies in clinical monitoring, emergency treatment, and drug abuse prevention. By summarizing the development trends of emerging detection technologies, this study provides a theoretical basis and practical reference for technological advancements in clinical drug monitoring and public health regulation.

, authors=Qin XIAO, Shu-mao GUO, Yu-tong HUANG, Xiao-bing LI, authorsList=Qin XIAO, Shu-mao GUO, Yu-tong HUANG, Xiao-bing LI, authorCompany=null, correspAuthors=Xiao-bing LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704824966435264, articleId=1291704824354066878, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=苯二氮䓬类镇静催眠药物检测的临床意义及仪器分析进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

近年来，镇静催眠药物使用不当造成的中毒情形呈上升趋势，相关死亡病例亦逐年增加。其疗效显著与滥用风险并存的双重特性，已成为全球公共卫生与临床诊疗的重要议题。苯二氮䓬类药物作为经典的镇静催眠类药物，在急诊科、精神科、心内科等临床科室应用广泛，但长期使用易引起药物蓄积、药物耐受及依赖风险。由于现代社会压力加剧以及人口老龄化加速，苯二氮䓬类药物非法使用和娱乐性滥用的市场仍然存在，越来越多的人试图通过此类药物改善睡眠质量或寻求精神愉悦，从而导致其滥用及中毒风险显著上升。文章概述了苯二氮䓬类药物在临床用药中的监测需求，介绍了最新的样品预处理技术，并综述了当前常用的分析技术体系，涵盖色谱、质谱及其联用技术的发展趋势，重点探讨不同检测技术在临床监测、急诊救治及药物滥用防控中的应用价值。通过总结新兴检测技术的发展趋势，为临床药物监测与公共卫生监管的技术升级提供理论依据与实践参考。

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肖琴（2000-），女，硕士研究生，主要从事苯二氮䓬类镇静催眠药物的体内外分析及临床应用方法学研究

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肖琴（2000-），女，硕士研究生，主要从事苯二氮䓬类镇静催眠药物的体内外分析及临床应用方法学研究

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