Article(id=1291704807258083651, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.17.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1742400000000, receivedDateStr=2025-03-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785896024764, onlineDateStr=2026-08-05, pubDate=1758038400000, pubDateStr=2025-09-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785896024764, onlineIssueDateStr=2026-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785896024764, creator=13701087609, updateTime=1785896024764, updator=13701087609, issue=Issue{id=1291704771212234905, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='17', pageStart='2401', pageEnd='2550', issueExtLink='null', onlineDate='null', pubDate='1758038400000', pubDateStr='2025-09-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785896016147, creator='13701087609', updateTime=1785896900366, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291708479866164175, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291708479866164176, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291704771212234905, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=2477, endPage=2482, ext={EN=ArticleExt(id=1291704807656542532, articleId=1291704807258083651, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of effects on aconite total base in rat myocardial function, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of total alkaloids of Aconitum carmichaelii on myocardial function in rats and its underlying mechanisms.
Methods SPF-grade Wistar rats were randomly assigned into five groups (n=10 each): blank group (0.9% NaCl), control group (isoproterenol 10 mg·kg-1), experimental-L group (2.72 g·kg-1 total alkaloids of A. carmichaelii), experimental-M group (3.68 g·kg-1), and experimental-H group (4.98 g·kg-1). All groups were gavaged once daily for 5 consecutive days. Thirty minutes after the last injection, T-wave amplitude on electrocardiogram was recorded. An isolated heart perfusion model was established to evaluate cardiac function and myocardial contractility. Myocardial cell activity and malondialdehyde content were measured, and real-time quantitative PCR was used to detect mRNA expression levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc-1α), B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax).
Results The T-wave amplitudes for the experimental -L, -M, -H groups, blank group and control group were (0.17±0.07), (0.29±0.05), (0.37±0.04), (0.30±0.07) and (0.36±0.04) mV, respectively; the myocardial cell activities were (0.46±0.05), (0.44±0.08), (0.35±0.07), (0.45±0.06) and (0.33±0.05) Abs, respectively; the while malondialdehyde contents were (2.56±0.28), (2.55±0.26), (2.86±0.28), (2.49±0.34) and (2.83±0.25) mmol·mL-1, respectively; the relative mRNA expression levels of Pgc-1α were 0.49±0.05, 0.41±0.07, 0.27±0.05, 0.48±0.06 and 0.35±0.05, respectively; the relative mRNA expression levels of Bax were 1.10±0.08, 1.25±0.09, 1.36±0.07, 1.09±0.09 and 1.33±0.07, respectively; the relative mRNA expression levels of Bcl-2 were 0.58±0.06, 0.51±0.05, 0.44±0.04, 0.56±0.08 and 0.45±0.03, respectively. Compared with the experimental -M, -H groups and blank group, the above indexes of the experimental -L group were statistically significant (all P<0.05).
Conclusion Lower doses of Aconitum carmichaelii total alkaloids positively influence ECG T-wave amplitude, cardiac function, and myocardial contractility, improve myocardial cell activity, and reduce oxidative stress, whereas high doses exert cardiotoxic effects.
, authors=Yu-guo ZHU
1a, Rui-ya SU
1a, Sheng GUO
1b, authorsList=Yu-guo ZHU, Rui-ya SU, Sheng GUO, authorCompany=null, correspAuthors=Sheng GUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291704808071778629, articleId=1291704807258083651, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=附子总碱对大鼠心肌功能影响的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究附子总碱对大鼠心肌功能的影响及其作用机制。
方法 将SPF级Wistar大鼠分为空白组、对照组及低、中、高剂量实验组，每组各10只。空白组灌胃给予0.9%NaCl；对照组灌胃给予10 mg·kg-1异丙肾上腺素；低、中、高剂量实验组分别按2.72、3.68、4.98 g·kg-1的剂量灌胃给予附子总碱。5组大鼠每天给药1次，连续给药5 d。给药5 d后，记录大鼠心脏T波变化，构建大鼠离体心脏灌注模型。观察各组大鼠离体心脏的心功能及心肌收缩功能，比较各组大鼠心肌细胞的活性和丙二醛含量变化，用实时荧光定量聚合酶链反应法检测心肌细胞过氧化物酶增殖激活受体γ辅助激活物1α（Pgc-1α）、B淋巴细胞瘤-2（Bcl-2）和Bcl-2相关X蛋白（Bax）mRNA相对表达水平。
结果 低、中、高剂量实验组、空白组和对照组在注射后30 min的T波变化幅度分别为（0.17±0.07）、（0.29±0.05）、（0.37±0.04）、（0.30±0.07）和（0.36±0.04）mV，心肌细胞活性分别为（0.46±0.05）、（0.44±0.08）、（0.35±0.07）、（0.45±0.06）和（0.33±0.05）Abs，丙二醛含量分别为（2.56±0.28）、（2.55±0.26）、（2.86±0.28）、（2.49±0.34）和（2.83±0.25）mmol·mL-1，Pgc-1α mRNA相对表达水平分别为0.49±0.05、0.41±0.07、0.27±0.05、0.48±0.06和0.35±0.05，Bax mRNA相对表达水平分别为1.10±0.08、1.25±0.09、1.36±0.07、1.09±0.09和1.33±0.07，Bcl-2 mRNA的相对表达水平分别为0.58±0.06、0.51±0.05、0.44±0.04、0.56±0.08和0.45±0.03。低剂量实验组的上述指标与中、高剂量实验组及空白组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 较低剂量的附子总碱对大鼠的心电T波、心功能及心肌收缩存在正向积极作用，能提高其心肌细胞活性，降低丙二醛含量，但高剂量的附子总碱对其心肌功能存在药物不良反应。
, authors=朱玉果
1a, 苏蕊雅
1a, 郭胜
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朱玉果（1992-），女，主治医师，主要从事动脉粥样硬化和心力衰竭相关研究
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