Article(id=1291405026514162197, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732032000000, receivedDateStr=2024-11-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824551466, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824551466, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824551466, creator=13701087609, updateTime=1785824551466, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1085, endPage=1090, ext={EN=ArticleExt(id=1291405026707100182, articleId=1291405026514162197, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of etomidate inhibiting the malignant biological behavior of bladder cancer BIU-87 cells by regulating the expression of mTOR/SIRT1, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of etomidate on the expression of mammalian sirolimus like target protein (mTOR)/silencing information regulatory factor 1 (SIRT1) gene to inhibit the proliferation, invasion and migration of bladder cancer BIU-87 cells.
Methods The BIU-87 cells were divided into normal group, positive control group and experimental -L, -M, -H groups. The normal group was given normal culture; the positive control group was treated with MEM medium containing paclitaxel at a final concentration of 15 mg·mL-1; the experimental -L, -M, -H groups were treated with MEM medium containing etomidate at final concentrations of 112.50, 225.00 and 450.00 mg·L-1, respectively. After 24 hours of intervention, the migration ability of cells was detected using the cell scratching method, the invasion ability of cells was detected using the Transwell method, the levels of glucose and lactate in cells were detected using enzyme-linked immunosorbent assay, and the expression levels of mTOR, SIRT1 and matrix metalloproteinase (MMP) proteins were detected using Western blotting.
Results The number of invasive cells in the experimental -M, -H groups, positive control group and normal group was 248.56±5.67, 117.37±16.72, 76.54±8.23 and 376.40±53.41; the migration distances were (22.30±2.89), (13.67±5.46), (8.63±2.07) and (38.24±5.24) μm; the glucose levels were (38.97±2.43), (29.75±3.58), (21.52±4.20) and (64.26±7.26) μmol·L-1; the lactate levels were (37.36±3.29), (20.32±5.67), (14.76±2.37) and (51.52±3.10) μmol·L-1; the phosphorylated mTOR/mTOR ratios were 0.26±0.05, 0.20±0.04, 0.15±0.03 and 0.47±0.07; the relative expression levels of SIRT1 protein were 0.23±0.01, 0.18±0.02, 0.09±0.02 and 0.72±0.13; the relative expression levels of MMP-9 protein were 0.19±0.05, 0.14±0.01, 0.10±0.01 and 0.28±0.04, respectively. Compared with positive control group and normal group, the differences of above indexes in experimental -M, -H groups were statistically significant (all P<0.05).
Conclusion Etomidate can effectively inhibit the proliferation, invasion and migration of BIU-87 cells by suppressing the expression of mTOR/SIRT1.
, authors=Xiao-shi LI, Shi-bin LI, Hui-ming ZHANG, Wen-bo YANG, authorsList=Xiao-shi LI, Shi-bin LI, Hui-ming ZHANG, Wen-bo YANG, authorCompany=null, correspAuthors=Wen-bo YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291405028703588887, articleId=1291405026514162197, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=依托咪酯调控mTOR/SIRT1表达抑制膀胱癌BIU-87细胞恶性生物学行为的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨依托咪酯调控哺乳动物西罗莫司靶蛋白（mTOR）/沉默信息调节因子1（SIRT1）基因表达对膀胱癌BIU-87细胞增殖、侵袭和迁移的影响。
方法 将BIU-87细胞分为正常组、阳性对照组和低、中、高剂量实验组。正常组给予正常培养；阳性对照组给予含终质量浓度为15 mg·mL-1紫杉醇的MEM培养基进行干预；低、中、高剂量实验组分别给予含终质量浓度为112.50、225.00和450.00 mg·L-1的依托咪酯的MEM培养基进行干预。干预24 h后，用细胞划痕法检测细胞的迁移能力，用Transwell法检测细胞的侵袭能力，用酶联免疫吸附试验法检测细胞中葡萄糖和乳酸水平，用蛋白质印迹法检测mTOR、SIRT1和基质金属蛋白酶（MMP）蛋白的表达水平。
结果 中、高剂量实验组和阳性对照组、正常组的侵袭细胞数分别为（248.56±5.67）、（117.37±16.72）、（76.54±8.23）和（376.40±53.41）个，迁移距离分别为（22.30±2.89）、（13.67±5.46）、（8.63±2.07）和（38.24±5.24）μm，葡萄糖水平分别为（38.97±2.43）、（29.75±3.58）、（21.52±4.20）和（64.26±7.26）μmol·L-1，乳酸水平分别为（37.36±3.29）、（20.32±5.67）、（14.76±2.37）和（51.52±3.10）μmol·L-1，磷酸化mTOR/mTOR比值分别为0.26±0.05、0.20±0.04、0.15±0.03和0.47±0.07，SIRT1蛋白相对表达水平分别为0.23±0.01、0.18±0.02、0.09±0.02和0.72±0.13，MMP-9蛋白相对表达水平分别为0.19±0.05、0.14±0.01、0.10±0.01和0.28±0.04。中、高剂量实验组的上述指标分别与阳性对照组和正常组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 依托咪酯能够通过抑制mTOR/SIRT1的表达，进而有效地抑制BIU-87细胞的增殖、侵袭和迁移。
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李晓石（1984-），男，主治医师，主要从事泌尿系肿瘤的相关临床诊疗和科研工作
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