Article(id=1291404998517182812, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728748800000, receivedDateStr=2024-10-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824544790, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824544790, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824544790, creator=13701087609, updateTime=1785824544790, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1062, endPage=1066, ext={EN=ArticleExt(id=1291404998701732189, articleId=1291404998517182812, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of ropivacaine erector spinae plane block combined with TIVA in the treatment of colorectal cancer patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of ropivacaine for erector spinae plane block (ESPB) combined with total intravenous anesthesia (TIVA) in patients undergoing colorectal cancer surgery.
Methods Patients with colorectal cancer were randomly divided into treatment and control groups. Before the general anesthesia induction, treatment group received deep injection of 0.375% ropivacaine solution (25 mL) for local anesthesia in the erector spinae plane. Two groups received anesthesia induction with 0.05 mg·kg-1 midazolam + 0.4 μg·kg-1 sufentanil + 1.5 mg·kg-1 propofol + 0.15 mg·kg-1 cisatracurium, and anesthesia maintenance with 3-4 mg·L-1 propofol + 0.5-1.0 μg·kg-1 sufentanil + 0.05-0.10 mg·kg-1 cisatracurium. The sufentanil dosage, hemodynamics, visual analogue scale (VAS) and Ramsay sedation scores, interleukin (IL)-6 and cortisol levels and safety were compared between two groups.
Results Treatment group were enrolled 57 cases, 5 cases dropped out, and 52 cases were finally included in the statistical analysis. Control group were enrolled 55 cases, 3 cases dropped out, and 52 cases were finally included in the statistical analysis. At extubation, heart rates of treatment and control groups were (89.54±5.41) and (101.98±8.58) beat·min-1, mean arterial pressures were (83.60±7.48) and (93.12±7.35) mmHg, and the differences were statistically significant (all P<0.05). Intraoperative sufentanil dosages of treatment and control groups were (16.35±2.54) and (23.77±3.02) μg, VAS scores at 24 h after operation were (2.98±0.42) and (3.67±0.58) points, IL-6 levels at 24 h after operation were (17.92±2.41) and (28.12±3.81) ng·L-1, cortisol levels at 24 h after operation were (154.88±24.06) and (187.46±27.51) ng·mL-1, respectively; the differences were statistically significant (all P<0.05). Ramsay scores at 1 and 24 h postoperatively showed no statistically significant differences between and within groups (all P>0.05). The adverse drug reactions of treatment group were block site hematoma, nausea and vomiting, while those in control group were nausea and vomiting, hypotension and delirium. The incidences of total adverse drug reactions in the treatment and control groups were 11.54% and 21.15%, without significant difference (P>0.05).
Conclusion Ropivacaine ESPB combined with TIVA can help the patients undergoing colorectal cancer surgery to maintain stable intraoperative hemodynamics, reduce sufentanil consumption and pain, decrease postoperative inflammatory and stress responses, without increasing the incidence of adverse drug reactions.
, authors=Xiao-xiao SONG, You-fa ZHOU, Gang CHEN, authorsList=Xiao-xiao SONG, You-fa ZHOU, Gang CHEN, authorCompany=null, correspAuthors=Gang CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404999142134110, articleId=1291404998517182812, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=罗哌卡因竖脊肌平面阻滞联合TIVA用于结直肠癌患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察罗哌卡因竖脊肌平面阻滞（ESPB）联合全凭静脉麻醉（TIVA）用于结直肠癌患者的临床疗效及安全性。
方法 将结直肠癌患者随机分为对照组和试验组。试验组在全麻诱导前，在竖脊肌深层面注射0.375%盐酸罗哌卡因注射液25 mL进行局部麻醉。然后，2组患者均给予0.05 mg·kg-1达咪唑仑+0.4 μg·kg-1舒芬太尼+1.5 mg·kg-1丙泊酚+0.15 mg·kg-1顺阿曲库铵进行麻醉诱导，均给予3~4 mg·L-1丙泊酚+0.5~1.0 μg·kg-1舒芬太尼+0.05~0.10 mg·kg-1苯磺酸顺阿曲库铵进行麻醉维持。比较2组患者的舒芬太尼用量，血流动力学，视觉模拟量表（VAS）和Ramsay镇静评分，白细胞介素（IL）-6和皮质醇水平，以及安全性。
结果 试验组入组57例，脱落5例，最终有52例纳入统计分析；对照组入组55例，脱落3例，最终有52例纳入统计分析。试验组和对照组拔管时的心率分别为（89.54±5.41）和（101.98±8.58）beat·min-1，平均动脉压分别为（83.60±7.48）和（93.12±7.35）mmHg，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的术中舒芬太尼用量分别为（16.35±2.54）和（23.77±3.02）μg，术后24 h VAS评分分别为（2.98±0.42）和（3.67±0.58）分，术后24 h IL-6水平分别为（17.92±2.41）和（28.12±3.81）ng·L-1，术后24 h皮质醇水平分别为（154.88±24.06）和（187.46±27.51）ng·mL-1，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组术后1、24 h的Ramsay评分在组间和组内比较，在统计学上差异均无统计学意义（均P>0.05）。试验组发生的药物不良反应有阻滞部位血肿和恶心呕吐，对照组发生的药物不良反应有恶心呕吐、低血压和谵妄。试验组和对照组的药物不良反应总发生率分别为11.54%和21.15%，在统计学上差异无统计学意义（P>0.05）。
结论 罗哌卡因ESPB联合TIVA有助于维持结直肠癌患者术中血流动力学稳定，减少舒芬太尼用量，减轻疼痛，降低术后炎症因子和应激反应水平，且不增加药物不良反应的发生率。
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宋潇潇（1987-），女，主治医师，主要从事麻醉方向的临床诊疗工作
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