Article(id=1291404968968310961, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731168000000, receivedDateStr=2024-11-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824537745, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824537745, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824537745, creator=13701087609, updateTime=1785824537745, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1072, endPage=1078, ext={EN=ArticleExt(id=1291404970692169906, articleId=1291404968968310961, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of
lncRNA MAGI1-
IT1 on biological behavior and epithelial mesenchymal transformation of breast cancer cells by regulating
miR-485-5
p/ACTG1 axis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of long non-coding RNA (lncRNA) MAGI1-IT1 on the proliferation, invasion, migration and epithelial mesenchymal transformation (EMT) of breast cancer cells by regulating the miR-485-5p/actin gamma 1 (ACTG1) axis.
Methods HCC1937 cells were cultured in vitro and randomly divided into control, si-MAGI1-IT1, miR-485-5p mimics, negative cotransfection and positive cotransfection groups. Control group was cultured normally without transfection; si-MAGI1-IT1 group was transfected with si-MAGI1-IT1; miR-485-5p mimics group was transfected with miR-485-5p mimics; negative cotransfection group was transfected with si-NC and NC-miR-485-5p; positive cotransfection group was given si-MAGI1-IT1 and miR-485-5p inhibitor combined transfection. Cell proliferation was detected by cell counting kit-8 method, cell migration was detected by cell scratch assay, cell invasion was detected by Transwell assay, and expression levels of lncRNA MAGI1-IT1, miR-485-5p and ACTG1 were detected by real-time fluorescence quantitative polymerase chain reaction method. The expression of proliferation and EMT-related proteins were detected by immunohistochemical staining.
Results The cell activities (optical density) of the control, si-MAGI1-IT1, miR-485-5p mimics, negative cotransfection and positive cotransfection groups were 0.89±0.12, 0.36±0.05, 0.32±0.03, 0.89±0.10 and 0.85±0.11; the migration rates were (91.82±11.13)%, (38.40±7.64)%, (33.17±6.03)%, (92.43±10.87)% and (86.10±10.76)%; the number of invasions was 296.50±23.48, 93.00±17.36, 76.50±15.01, 302.50±25.32 and 269.00±24.92; the relative expression levels of lncRNA MAGI1-IT1 were 0.98±0.11, 0.29±0.06, 0.96±0.10, 1.00±0.12 and 0.30±0.07; the relative expression levels of miR-485-5p were 0.99±0.13, 2.12±0.16, 2.20±0.18, 0.98±0.15 and 1.04±0.16; the relative expression levels of ACTG1 were 1.01±0.12, 0.34±0.05, 0.31±0.07, 1.02±0.14 and 0.97±0.11; the positive expression levels of proliferating cell nuclear antigen (optical density) were 1.65±0.16, 0.53±0.12, 0.45±0.08, 1.64±0.14 and 1.60±0.17; the positive expression levels of Cyclin D1 (optical density) were 1.53±0.15, 0.46±0.11, 0.40±0.06, 1.52±0.14 and 1.48±0.13; the positive expression levels of Vimentin (optical density) were 1.49±0.14, 0.45±0.07, 0.39±0.06, 1.50±0.12 and 1.45±0.13, respectively. The above indexes in the si-MAGI1-IT1 group were compared with the control group, the above indexes in the miR-485-5p mimics group (except lncRNA MAGI1-IT1) were compared with the control group, the above indexes in the positive cotransfection group (except lncRNA MAGI1-IT1) were compared with the si-MAGI1-IT1 group, the differences were statistically significant (all P<0.05).
Conclusion Knockdown of lncRNA MAGI1-IT1 can reduce the expression of ACTG1 by up-regulating miR-485-5p, thereby inhibiting the proliferation, migration, invasion and EMT of breast cancer cells.
, authors=Feng WANG, Wen-yan WANG, Geng-bao QU, Qiang ZHU, authorsList=Feng WANG, Wen-yan WANG, Geng-bao QU, Qiang ZHU, authorCompany=null, correspAuthors=Feng WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404971933683891, articleId=1291404968968310961, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=
lncRNA MAGI1-
IT1调节
miR-485-5
p/ACTG1轴对乳腺癌细胞生物学行为和上皮间质转化的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨长链非编码RNA（lncRNA）MAGI1-IT1调节miR-485-5p/肌动蛋白γ1（ACTG1）轴对乳腺癌细胞增殖、侵袭、迁移及上皮间质转化（EMT）的影响。
方法 将体外培养HCC1937细胞分为对照组、si-MAGI1-IT1组、miR-485-5p mimics组、阴性共转染组和阳性共转染组。对照组正常培养，不转染；si-MAGI1-IT1组给予si-MAGI1-IT1转染；miR-485-5p mimics组给予miR-485-5p mimics转染；阴性共转染组给予si-NC和NC-miR-485-5p联合转染；阳性共转染组给予si-MAGI1-IT1和miR-485-5p inhibitor联合转染。用细胞计数试剂盒-8法检测细胞的增殖情况，用细胞划痕实验法检测细胞的迁移情况，用Transwell实验法检测细胞的侵袭情况，用实时荧光定量聚合酶链反应检测lncRNA MAGI1-IT1、miR-485-5p及ACTG1的表达水平，用免疫组化染色法检测增殖和EMT相关蛋白的表达情况。
结果 对照组、si-MAGI1-IT1组、miR-485-5p mimics组、阴性共转染组和阳性共转染组的细胞活性（光密度值）分别为0.89±0.12、0.36±0.05、0.32±0.03、0.89±0.10和0.85±0.11，迁移率分别为（91.82±11.13）%、（38.40±7.64）%、（33.17±6.03）%、（92.43±10.87）%和（86.10±10.76）%，侵袭细胞数分别为（296.50±23.48）、（93.00±17.36）、（76.50±15.01）、（302.50±25.32）和（269.00±24.92）个，lncRNA MAGI1-IT1相对表达水平分别为0.98±0.11、0.29±0.06、0.96±0.10、1.00±0.12和0.30±0.07，miR-485-5p相对表达水平分别为0.99±0.13、2.12±0.16、2.20±0.18、0.98±0.15和1.04±0.16，ACTG1相对表达水平分别为1.01±0.12、0.34±0.05、0.31±0.07、1.02±0.14和0.97±0.11，增殖细胞核抗原阳性表达水平（光密度值）分别为1.65±0.16、0.53±0.12、0.45±0.08、1.64±0.14和1.60±0.17，细胞周期蛋白D1阳性表达水平（光密度值）分别为1.53±0.15、0.46±0.11、0.40±0.06、1.52±0.14和1.48±0.13，波形蛋白阳性表达水平（光密度值）分别为1.49±0.14、0.45±0.07、0.39±0.06、1.50±0.12和1.45±0.13。si-MAGI1-IT1组的上述指标与对照组比较，miR-485-5p mimics组的上述指标（除lncRNA MAGI1-IT1外）与对照组比较，阳性共转染组的上述指标（除lncRNA MAGI1-IT1外）与si-MAGI1-IT1组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 敲低lncRNA MAGI1-IT1可以通过上调miR-485-5p来降低ACTG1表达，从而抑制乳腺癌细胞的增殖、迁移、侵袭及EMT。
, authors=王峰, 王文彦, 曲更宝, 朱强, authorsList=王峰, 王文彦, 曲更宝, 朱强, authorCompany=null, correspAuthors=王峰, authorNote=
王峰（1981-），男，副主任医师，主要从事乳腺肿瘤、浸润性导管癌、癌前病变的相关研究
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