Article(id=1291404925645345750, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728662400000, receivedDateStr=2024-10-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824527416, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824527416, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824527416, creator=13701087609, updateTime=1785824527416, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1051, endPage=1055, ext={EN=ArticleExt(id=1291404925855060951, articleId=1291404925645345750, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of evolocumab combined with rosuvastatin in the treatment of patients with acute myocardial infarction after PCI, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of evolocumab injection combined with rosuvastatin tablets in the treatment of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).
Methods The AMI patients were randomly divided into control group and treatment group. The control group was given oral rosuvastatin at an initial dose of 10 mg daily, if the level of low-density lipoprotein cholesterol (LDL-C) >1.4 mmol·L-1, the dose was increased to 20 mg daily. On the basis of control group, the treatment group received evolocumab 140 mg, subcutaneous injection of the abdomen, once every 2 weeks. Two groups were treated for 6 months. The clinical efficacy, myocardial injury markers, lipid metabolism parameters, overall incidence of cardiovascular events and safety were compared between two groups.
Results Treatment group were enrolled 55 cases, 2 cases dropped out, and 53 cases were finally included in the statistical analysis. Control group were enrolled 53 cases, 1 case dropped out, and 52 cases were finally included in the statistical analysis. After treatment, the total effective rates of treatment and control groups were 92.45% (49 cases/53 cases) and 78.85% (41 cases / 52 cases), with statistically significant difference (P<0.05). After treatment, the levels of high-sensitivity cardiac troponin were (2.02±0.61) and (2.78±0.73) ng·L-1, the levels of creatine kinase-MB were (38.90±6.47) and (50.05±6.15) U·L-1, the levels of total cholesterol were (2.27±0.15) and (3.15±0.19) mmol·L-1, the levels of triglycerides were (1.61±0.12) and (1.77±0.17) mmol·L-1, the levels of LDL-C were (1.25±0.15) and (2.08±0.13) mmol·L-1, the overall incidences of cardiovascular events were 5.77% and 16.98%, respectively. The differences of above indexes were statistically significant (all P<0.05). The adverse drug reactions of treatment group were skin rash, elevated creatine kinase and liver injury, while those in the control group were nausea and vomiting, skin rash and liver injury. The total incidences of adverse drug reactions in treatment and control groups were 9.43% and 5.77%, without statistically significant difference (P>0.05).
Conclusion Evolocumab injection combined with rosuvastatin tablets has a definitive clinical efficacy in the treatment of patients with AMI after PCI, which can significantly improve cardiac function, reduce the risk of myocardial injury and cardiovascular events, with good safety.
, authors=Zhong-chun HE
1a, Qiu-xiang LONG
1b, Bo DONG
1a, authorsList=Zhong-chun HE, Qiu-xiang LONG, Bo DONG, authorCompany=null, correspAuthors=Zhong-chun HE, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404926148662232, articleId=1291404925645345750, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=依洛尤单抗联合瑞舒伐他汀用于PCI术后急性心肌梗死患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察依洛尤单抗注射液联合瑞舒伐他汀片用于经皮冠状动脉介入治疗（PCI）术后急性心肌梗死（AMI）患者的临床疗效及安全性。
方法 将AMI患者随机分为对照组和试验组。对照组给予口服瑞舒伐他汀，初始剂量为每日10 mg，若患者的低密度脂蛋白胆固醇（LDL-C）水平超过1.4 mmol·L-1，剂量增加至每日20 mg；试验组在对照组治疗的基础上，联合依洛尤单抗140 mg，腹部皮下注射，每2周给药1次。2组患者均连续治疗6个月。比较2组患者的临床疗效、心肌损伤标志物、血脂代谢指标、心血管事件总发生率，以及安全性。
结果 试验组入组55例，脱落2例，最终有53例纳入统计分析；对照组入组53例，脱落1例，最终有52例纳入统计分析。治疗后，试验组和对照组的总有效率分别为92.45%（49例/53例）和78.85%（41例/52例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的高敏心肌肌钙蛋白水平分别为（2.02±0.61）和（2.78±0.73）ng·L-1，肌酸激酶MB水平分别为（38.90±6.47）和（50.05±6.15）U·L-1，总胆固醇水平分别为（2.27±0.15）和（3.15±0.19）mmol·L-1，三酰甘油水平分别为（1.61±0.12）和（1.77±0.17）mmol·L-1，LDL-C水平分别为（1.25±0.15）和（2.08±0.13）mmol·L-1，心血管事件总发生率分别为5.77%和16.98%，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有皮疹、肌酸激酶升高和肝损伤，对照组的药物不良反应主要有恶心呕吐、皮疹和肝损伤。试验组和对照组的总药物不良反应发生率分别为9.43%和5.77%，在统计学上差异无统计学意义（P>0.05）。
结论 依洛尤单抗注射液联合瑞舒伐他汀片用于PCI术后AMI患者的临床疗效显著，其能够显著改善患者的心功能，减少心肌损伤和心血管事件的风险，且安全性较好。
, authors=何仲春
1a, 龙秋香
1b, 董博
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何仲春（1977-），男，副主任医师，主要从事心血管疾病的临床诊疗工作
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