Article(id=1291404913616089956, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729353600000, receivedDateStr=2024-10-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824524548, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824524548, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824524548, creator=13701087609, updateTime=1785824524548, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1218, endPage=1222, ext={EN=ArticleExt(id=1291404913804833637, articleId=1291404913616089956, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of influencing factors of dose-corrected concentration of the active metabolites of oxcarbazepine based on therapeutic drug monitoring, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the influencing factors of the dose-corrected concentration (C/D) of the active metabolite of oxcarbazepine (OXC) [10-hydroxycarbazepine (MHD)] and to provide the reference for the rational clinical use of this drug.
Methods A total of 161 MHD blood concentrations were collected from the therapeutic drug monitoring (TDM) data of inpatients who received OXC treatment, as well as demographic information, comedications, diagnosis, and associated clinical chemistry results. Data analysis was carried out through the SPSS 27.0 software.
Results The effects of age, body mass index (BMI), comedications and diagnosis on MHD C/D values were statistically significant (all P<0.05). The C/D value of patients under 18 years old was higher than that of patients between 18 to 65 years old. The C/D value of female patients was higher than that of male patients in adults. The C/D value of the underweight group was higher than the normal, overweight and obese groups. The C/D value of patients combined with valproic acid was significantly lower than that of patients who didn’t. The C/D value of epilepsy patients was significantly lower than that of patients who weren’t diagnosed with this disease. Only 11 patients (8.20%) had blood sodium below the normal value range after medication, and there was no significant difference in blood sodium value, serum creatinine value, and glutamic-pyruvic transaminase value before and after treatment (all P>0.05). The results of multiple linear regression analysis showed that BMI had an effect on the C/D of MHD (P<0.05).
Conclusion OXC has relatively good safety profile, and the effects of gender, age, BMI, comedications and diagnosis should be taken into consideration when OXC is prescribed.
, authors=Ya LUO
1, Guo-wei DENG
1, De-wei SHANG
1, 2, Yu-guan WEN
1, 2, Jin-qing HU
1, 2, authorsList=Ya LUO, Guo-wei DENG, De-wei SHANG, Yu-guan WEN, Jin-qing HU, authorCompany=null, correspAuthors=Jin-qing HU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404914102629222, articleId=1291404913616089956, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于治疗药物监测的奥卡西平活性代谢物剂量校正浓度影响因素分析, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨影响奥卡西平（OXC）活性代谢物[10-羟基卡马西平（MHD）]的剂量校正浓度（C/D）的因素，为该药的临床合理应用提供参考。
方法 收集接受OXC治疗且进行治疗药物监测（TDM）的住院患者的MHD血药浓度监测数据161份，并收集该类人群的人口学、合并用药、诊断及生化检验等相关资料，用SPSS 27.0软件进行数据统计并对结果进行分析。
结果 年龄、体质量指数（BMI）、合并用药、诊断对MHD C/D值的影响均有统计学意义（均P<0.05）。18岁以下的患者C/D高于18～65岁患者；成年患者中，女性C/D值显著高于男性；低体质量组C/D值均显著高于正常体质量组、超质量组及肥胖组；联合使用丙戊酸组C/D显著低于非丙戊酸组；OXC在治疗癫痫患者时C/D值显著低于治疗非癫痫患者。仅11例（8.20%）患者用药后血钠低于正常值范围，且治疗前后血钠值、血清肌酸酐值、谷丙转氨酶值均无显著性差异（均P>0.05）。多元线性回归分析结果表明，BMI对MHD的C/D具有影响（P<0.05）。
结论 OXC安全性较好，临床使用OXC时，应根据性别、年龄、BMI、合并用药、诊断进行个体化给药。
, authors=罗雅
1, 邓国卫
1, 尚德为
1, 2, 温预关
1, 2, 胡晋卿
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罗雅（2000-），女，硕士研究生，主要从事药物评价及医院药学方面的研究
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