Article(id=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734019200000, receivedDateStr=2024-12-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824523821, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824523821, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824523821, creator=13701087609, updateTime=1785824523821, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1341, endPage=1345, ext={EN=ArticleExt(id=1291404910789124664, articleId=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the mechanism of intervention of effective ingredients in traditional Chinese medicine on tumor bone metastasis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Bone is the main target organ for malignant tumor metastasis, but there is still a lack of effective early diagnosis and treatment methods in clinical practice. Therefore, bone metastasis has become an important cause of death in patients with malignant tumors. Bone metastasis often causes a series of bone related events (SREs) such as pathological fractures, spinal cord compression, bone pain, and bone radiation therapy, seriously affecting the quality of life of patients. Based on previous researches and combined with domestic and foreign literatures. This review aims to elucidate the mechanism of bone microenvironment formation and escape, colonization, dormancy, reactivation, and proliferation in six stages. And summarize the latest research progress on the intervention of traditional Chinese medicine monomers and formulas in the process of tumor bone metastasis, clarify whether there is a synergistic effect of integrated traditional Chinese and Western medicine treatment on bone metastasis, in order to provide new ideas and medication basis for the in-depth study of the pathogenesis and drug treatment of tumor bone metastasis, aiming to further illustrate the advantages of multi-target treatment of traditional Chinese medicine and its important role in the treatment of tumor bone metastasis, and improve the efficacy of bone metastasis.
, authors=Li-jun WANG
1, Hong-zhuan LI
2, Ya-sai YAO
1, authorsList=Li-jun WANG, Hong-zhuan LI, Ya-sai YAO, authorCompany=null, correspAuthors=Hong-zhuan LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404911103697465, articleId=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药有效成分干预肿瘤骨转移作用机制的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=
骨是恶性肿瘤转移的主要靶器官,但目前临床上仍缺乏有效的早期诊治手段,因此骨转移成为恶性肿瘤患者死亡的重要原因。骨转移常引起病理性骨折、脊髓压迫、骨痛、骨放疗等一系列骨相关事件(SREs),严重影响患者生活质量。本综述拟在前期研究的基础上,结合国内外文献,从骨微环境的形成及逃逸、定殖、休眠、再激活、增殖6个环节,阐明其发生机制,并总结中药单体及中药复方干预肿瘤骨转移进程的最新研究进展,明确中西医综合治疗对骨转移是否存在协同作用,以期为肿瘤骨转移发病机制及药物治疗的深入研究提供新思路和用药依据,旨在进一步说明中医药多靶点治疗的优势及在治疗肿瘤骨转移中发挥的重要作用,提高骨转移疗效。
, authors=王丽君
1, 李红专
2, 姚亚赛
1, authorsList=王丽君, 李红专, 姚亚赛, authorCompany=null, correspAuthors=李红专, authorNote=
王丽君(1997-),女,硕士研究生,主要从事骨与软组织肿瘤研究
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