Article(id=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734019200000, receivedDateStr=2024-12-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824523821, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824523821, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824523821, creator=13701087609, updateTime=1785824523821, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1341, endPage=1345, ext={EN=ArticleExt(id=1291404910789124664, articleId=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the mechanism of intervention of effective ingredients in traditional Chinese medicine on tumor bone metastasis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Bone is the main target organ for malignant tumor metastasis, but there is still a lack of effective early diagnosis and treatment methods in clinical practice. Therefore, bone metastasis has become an important cause of death in patients with malignant tumors. Bone metastasis often causes a series of bone related events (SREs) such as pathological fractures, spinal cord compression, bone pain, and bone radiation therapy, seriously affecting the quality of life of patients. Based on previous researches and combined with domestic and foreign literatures. This review aims to elucidate the mechanism of bone microenvironment formation and escape, colonization, dormancy, reactivation, and proliferation in six stages. And summarize the latest research progress on the intervention of traditional Chinese medicine monomers and formulas in the process of tumor bone metastasis, clarify whether there is a synergistic effect of integrated traditional Chinese and Western medicine treatment on bone metastasis, in order to provide new ideas and medication basis for the in-depth study of the pathogenesis and drug treatment of tumor bone metastasis, aiming to further illustrate the advantages of multi-target treatment of traditional Chinese medicine and its important role in the treatment of tumor bone metastasis, and improve the efficacy of bone metastasis.

, authors=Li-jun WANG1, Hong-zhuan LI2, Ya-sai YAO1, authorsList=Li-jun WANG, Hong-zhuan LI, Ya-sai YAO, authorCompany=null, correspAuthors=Hong-zhuan LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404911103697465, articleId=1291404910566826551, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药有效成分干预肿瘤骨转移作用机制的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

骨是恶性肿瘤转移的主要靶器官,但目前临床上仍缺乏有效的早期诊治手段,因此骨转移成为恶性肿瘤患者死亡的重要原因。骨转移常引起病理性骨折、脊髓压迫、骨痛、骨放疗等一系列骨相关事件(SREs),严重影响患者生活质量。本综述拟在前期研究的基础上,结合国内外文献,从骨微环境的形成及逃逸、定殖、休眠、再激活、增殖6个环节,阐明其发生机制,并总结中药单体及中药复方干预肿瘤骨转移进程的最新研究进展,明确中西医综合治疗对骨转移是否存在协同作用,以期为肿瘤骨转移发病机制及药物治疗的深入研究提供新思路和用药依据,旨在进一步说明中医药多靶点治疗的优势及在治疗肿瘤骨转移中发挥的重要作用,提高骨转移疗效。

, authors=王丽君1, 李红专2, 姚亚赛1, authorsList=王丽君, 李红专, 姚亚赛, authorCompany=null, correspAuthors=李红专, authorNote=

王丽君(1997-),女,硕士研究生,主要从事骨与软组织肿瘤研究

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李红专,主任医师,硕士生导师 Tel: 15002552158 E-mail:
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中药有效成分干预肿瘤骨转移作用机制的研究现状
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王丽君 1 , 李红专 2 , 姚亚赛 1
中国临床药理学杂志 | 综述 2025,41(9): 1341-1345
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中国临床药理学杂志 |综述 2025 , 41 (9) : 1341 -1345
中药有效成分干预肿瘤骨转移作用机制的研究现状
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王丽君1, 李红专2 , 姚亚赛1
作者信息
  • 1.甘肃中医药大学 中医临床学院,甘肃 兰州 730030
  • 2.甘肃省中医院 骨与软组织肿瘤科,甘肃 兰州 730050
通讯作者:
李红专,主任医师,硕士生导师 Tel: 15002552158 E-mail:
作者简介:

王丽君(1997-),女,硕士研究生,主要从事骨与软组织肿瘤研究

Research status of the mechanism of intervention of effective ingredients in traditional Chinese medicine on tumor bone metastasis
Li-jun WANG1, Hong-zhuan LI2 , Ya-sai YAO1
Affiliations
  • 1.Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730030, Gansu Province, China
  • 2.Department of Bone and Soft Tissue Oncology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, Gansu Province, China
出版时间: 2025-05-17 doi: 10.13699/j.cnki.1001-6821.2025.09.025
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骨是恶性肿瘤转移的主要靶器官,但目前临床上仍缺乏有效的早期诊治手段,因此骨转移成为恶性肿瘤患者死亡的重要原因。骨转移常引起病理性骨折、脊髓压迫、骨痛、骨放疗等一系列骨相关事件(SREs),严重影响患者生活质量。本综述拟在前期研究的基础上,结合国内外文献,从骨微环境的形成及逃逸、定殖、休眠、再激活、增殖6个环节,阐明其发生机制,并总结中药单体及中药复方干预肿瘤骨转移进程的最新研究进展,明确中西医综合治疗对骨转移是否存在协同作用,以期为肿瘤骨转移发病机制及药物治疗的深入研究提供新思路和用药依据,旨在进一步说明中医药多靶点治疗的优势及在治疗肿瘤骨转移中发挥的重要作用,提高骨转移疗效。

中医药  /  肿瘤  /  骨转移  /  作用机制

Bone is the main target organ for malignant tumor metastasis, but there is still a lack of effective early diagnosis and treatment methods in clinical practice. Therefore, bone metastasis has become an important cause of death in patients with malignant tumors. Bone metastasis often causes a series of bone related events (SREs) such as pathological fractures, spinal cord compression, bone pain, and bone radiation therapy, seriously affecting the quality of life of patients. Based on previous researches and combined with domestic and foreign literatures. This review aims to elucidate the mechanism of bone microenvironment formation and escape, colonization, dormancy, reactivation, and proliferation in six stages. And summarize the latest research progress on the intervention of traditional Chinese medicine monomers and formulas in the process of tumor bone metastasis, clarify whether there is a synergistic effect of integrated traditional Chinese and Western medicine treatment on bone metastasis, in order to provide new ideas and medication basis for the in-depth study of the pathogenesis and drug treatment of tumor bone metastasis, aiming to further illustrate the advantages of multi-target treatment of traditional Chinese medicine and its important role in the treatment of tumor bone metastasis, and improve the efficacy of bone metastasis.

Chinese medicine  /  tumor  /  bone metastasis  /  mechanism
王丽君, 李红专, 姚亚赛. 中药有效成分干预肿瘤骨转移作用机制的研究现状. 中国临床药理学杂志, 2025 , 41 (9) : 1341 -1345 . DOI: 10.13699/j.cnki.1001-6821.2025.09.025
Li-jun WANG, Hong-zhuan LI, Ya-sai YAO. Research status of the mechanism of intervention of effective ingredients in traditional Chinese medicine on tumor bone metastasis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (9) : 1341 -1345 . DOI: 10.13699/j.cnki.1001-6821.2025.09.025

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doi: 10.13699/j.cnki.1001-6821.2025.09.025
  • 接收时间:2024-12-13
  • 首发时间:2026-08-04
  • 出版时间:2025-05-17
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    1.甘肃中医药大学 中医临床学院,甘肃 兰州 730030
    2.甘肃省中医院 骨与软组织肿瘤科,甘肃 兰州 730050

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李红专,主任医师,硕士生导师 Tel: 15002552158 E-mail:
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2种不同金属材料的力学参数

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Genus
种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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