Article(id=1291404897686118854, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404875351449891, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.09.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735401600000, receivedDateStr=2024-12-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824520751, onlineDateStr=2026-08-04, pubDate=1747411200000, pubDateStr=2025-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824520751, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824520751, creator=13701087609, updateTime=1785824520751, updator=13701087609, issue=Issue{id=1291404875351449891, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1747411200000', pubDateStr='2025-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824515426, creator='13701087609', updateTime=1785824515426, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1305, endPage=1309, ext={EN=ArticleExt(id=1291404897900028359, articleId=1291404897686118854, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Determination of propofol in Beagle dogs plasma by LC-MS/MS, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of propofol medium/long chain fat milk in Beagle dogs plasma, and to investigate the pharmacokinetics and bioequivalence of the reference preparation of propofol medium/long chain fat milk injection and the subject preparation after intravenous injection in Beagle dogs.
Methods The protein precipitation method was used for pretreatment, and the chromatographic column was Inert Sustain AQ-C18 column (50.0 mm×2.1 mm, 5 μm). Mobile phase: 0.1% ammonia-ammonium acetate aqueous solution, flow rate: 0.4 mL·min-1, column temperature: 40 ℃; the injection volume was 10 μL; ion source: electrospray ion source, negative ion mode, multi-reaction detection. The specificity, standard curve and lower limit of quantitation, precision and recovery, stability and reproducibility of the method were investigated.
Results The linear range of propofol was 0.05-10.00 μg·mL-1, the lower limit of quantitation was 0.05 μg·mL-1, the accuracy was 94.2%-105.0%, the intra-day and inter-day precision was less than 20%, and the stability was good. The Cmax of the reference preparation and the test preparation were (8.75±2.66) and (8.15±2.78)μg·mL-1 and the AUClast were (1.71±0.45) and (1.88±0.42) h·μg·mL-1, respectively.
Conclusion A simple, sensitive and accurate LC-MS/MS method is established for the determination of propofol.
, authors=Hao HU
1, 2, Xian YANG
2, 3, Hai-ting HOU
2, 3, Fang-hong ZHAO
2, 3, Xiao-yang MA
2, 3, Jie YANG
2, 4, Yao-dong WANG
2, 4, authorsList=Hao HU, Xian YANG, Hai-ting HOU, Fang-hong ZHAO, Xiao-yang MA, Jie YANG, Yao-dong WANG, authorCompany=null, correspAuthors=Xian YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404900198506952, articleId=1291404897686118854, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=用LC-MS/MS测定Beagle犬血浆中丙泊酚的浓度, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立测定Beagle犬血浆中丙泊酚中/长链脂肪乳的液相色谱串联质谱（LC-MS/MS）方法，探讨丙泊酚中/长链脂肪乳注射液参比制剂和受试者制剂静脉注射后，在Beagle犬体内的药代动力学和生物等效性。
方法 用蛋白沉淀法进行预处理；色谱柱：Inert Sustain AQ-C18柱（50.0 mm×2.10 mm，5 μm）；流动相： 0.1%氨水-醋酸铵水溶液；流速：0.4 mL·min-1；柱温：40 ℃；进样量：10 μL；离子源：电喷雾离子源，负离子模式，多反应检测。考察该方法的专属性、标准曲线和定量下限、精密度与回收率、稳定性以及重现性。
结果 丙泊酚在0.05~10.00 μg·mL-1内，线性关系良好，定量下限为0.05 μg·mL-1，准确度在94.2%~105.0%，批内、批间精密度均小于20%，稳定性好。参比制剂和受试制剂的Cmax分别为（8.75±2.66）和（8.15±2.78）μg·mL-1，AUClast分别为（1.71±0.45）和（1.88±0.42）h·μg·mL-1。
结论 本研究建立了一种简便、灵敏、准确的LC-MS/MS测定方法，可用于测定丙泊酚的含量。
, authors=胡皓
1, 2, 杨娴
2, 3, 侯海婷
2, 3, 赵方红
2, 3, 马晓阳
2, 3, 杨洁
2, 4, 王耀东
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胡皓（2000-），男，硕士研究生，主要从事新药临床前评价研究
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2.Pharmaceutical Research Institute of Shijiazhuang No.4 Pharmaceutical Co., Ltd., Shijiazhuang 050000, Hebei Province, China
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2.石家庄四药有限公司 研发中心，河北 石家庄 050000
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