Article(id=1291404891801506521, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734796800000, receivedDateStr=2024-12-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824519348, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824519348, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824519348, creator=13701087609, updateTime=1785824519348, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1556, endPage=1561, ext={EN=ArticleExt(id=1291404892262879962, articleId=1291404891801506521, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of niraparib on ovarian cancer proliferation and migration through regulation of TCF4 and inhibition of the Wnt/β-catenin signaling pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of niraparib (Nira) on ovarian cancer cell proliferation and migration by inhibiting the wingless MMTV integration site family member (Wnt)/beta-catenin (β-catenin) signaling pathway through the regulation of transcription factor 4 gene (TCF4).
Methods SKOV3 cells were divided into control group (normal culture without any treatment), OE-NC group (10 μmol·L-1 Nira+ transfection OE-NC treatment) and OE-TCF4 group (10 μmol·L-1 Nira+ transfection OE-TCF4 treatment), experimental-L, M, H groups (5, 10, 15 μmol·L-1 Nira treatment). Real-time fluorescence quantitative polymerase chain reaction and Western blotting were used to detect the protein and mRNA expression level of TCF4; cell viability was detected by cell counting kit-8 (CCK-8); and cell invasion ability was detected by Transwell. The expression levels of Wnt/β-catenin pathway-related proteins were detected by immunofluorescence.
Results The 48 h cell survival rates in control group, experimental-L, -M, -H groups were (98.96±3.13)%, (77.53±7.03)%, (58.31±7.52)% and (35.88±5.97)%, respectively. The relative mRNA expression levels of TCF4 in the control group and the experimental-M group were 1.00±0.16 and 0.45±0.07, respectively; while the relative protein expression levels of TCF4 were 1.00±0.12 and 0.43±0.06, respectively. The number of invasive cells in control group, experimental-M group, OE-NC group and OE-TCF4 group were 115.77±16.57, 60.81±8.80, 66.43±8.98 and 99.25±13.73, respectively; the relative fluorescence intensities of β-catenin were 1.00±0.13, 0.15±0.03, 0.17±0.04 and 0.60±0.11; the relative fluorescence intensities of cancer-Myc were 1.00±0.15, 0.07±0.01, 0.08±0.02 and 0.54±0.09, respectively; the relative fluorescence intensities of matrix metalloproteinase-9 (MMP-9) were 1.00±0.13, 0.06±0.01, 0.07±0.02 and 0.28±0.05, respectively. The control group was compared with experimental-M group, and the OE-TCF4 group was compared with OE-NC group, there were statistically significant differences in the above indexes (all P<0.05).
Conclusion Nira can inhibit the activity and invasion of ovarian cancer SKOV3 cells, which may be related to the down-regulation of TCF4 to inhibit the activation of Wnt/β-catenin signaling pathway.
, authors=Shao-wen MA, Lin LUO, authorsList=Shao-wen MA, Lin LUO, authorCompany=null, correspAuthors=Lin LUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404893068186331, articleId=1291404891801506521, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=尼拉帕尼通过调控TCF4抑制Wnt/β-catenin信号通路对卵巢癌增殖和迁移的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨尼拉帕尼（Nira）通过调控转录因子4（TCF4）抑制无翅型MMTV整合位点家族成员（Wnt）/β-连环蛋白（β-catenin）信号通路对卵巢癌细胞增殖、迁移的影响。
方法 将SKOV3细胞分为对照组（正常培养不做任何处理）、OE-NC组（10 μmol·L-1 Nira+转染OE-NC处理）、OE-TCF4组（10 μmol·L-1 Nira+转染OE-TCF4处理）和低、中、高剂量实验组（5、10、15 μmol·L-1 Nira处理）。用实时荧光定量聚合酶链反应和蛋白质印迹法检测TCF4的蛋白和mRNA表达水平，用细胞计数试剂盒-8检测细胞活力，用Transwell检测细胞侵袭能力，用免疫荧光法检测Wnt/β-catenin通路相关蛋白的表达水平。
结果 对照组和低、中、高剂量实验组的48 h细胞存活率分别为（98.96±3.13）%、（77.53±7.03）%、（58.31±7.52）%和（35.88±5.97）%；对照组和中剂量实验组的TCF4 mRNA相对表达水平分别为1.00±0.16和0.45±0.07，TCF4蛋白相对表达水平分别为1.00±0.12和0.43±0.06；对照组、中剂量实验组、OE-NC组和OE-TCF4组的细胞侵袭个数分别为（115.77±16.57）、（60.81±8.80）、（66.43±8.98）和（99.25±13.73）个，β-catenin相对荧光强度分别为1.00±0.13、0.15±0.03、0.17±0.04和0.60±0.11，Myc原癌基因相对荧光强度分别为1.00±0.15、0.07±0.01、0.08±0.02和0.54±0.09，基质金属蛋白酶9相对荧光强度分别为1.00±0.13、0.06±0.01、0.07±0.02和0.28±0.05。对照组的上述指标与中剂量实验组相比，OE-TCF4组的上述指标与OE-NC组相比，在统计学上差异均有统计学意义（均P<0.05）。
结论 Nira可以抑制卵巢癌SKOV3细胞的活性及侵袭，可能通过下调TCF4抑制Wnt/β-catenin通路激活。
, authors=马少文, 罗琳, authorsList=马少文, 罗琳, authorCompany=null, correspAuthors=罗琳, authorNote=
马少文（1990-），男，硕士研究生，主要从事免疫药理学方面的研究
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