Article(id=1291404884713132730, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1734710400000, receivedDateStr=2024-12-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824517657, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824517657, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824517657, creator=13701087609, updateTime=1785824517657, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1527, endPage=1531, ext={EN=ArticleExt(id=1291404886265025211, articleId=1291404884713132730, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Preventive effects of potassium citrate sustained-release tablets on stent mural calculi after ureteral lithotripsy for upper urinary tract calculi, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the preventive effect of potassium citrate sustained-release tablets on stent mural calculi after ureteral lithotripsy for upper urinary tract calculi and influence on urinary calcium ion and urinary oxalic acid concentration.
Methods The patients with upper urinary tract calculi who underwent ureteral lithotripsy were randomly divided into control group and treatment group. Both groups of patients received routine dietary guidance and health education after surgery. The control group received routine anti-infection, pain relief and stone removal treatment after surgery, while the treatment group received oral potassium citrate sustained-release tablets on the basis of the control group after surgery (1.08 g per time, 3 times a day) continuously until the ureteral stent tube was removed. The ureteral stent tube was removed at 4 or 8 weeks after surgery based on the patient’s recovery status, and the occurrence of stent mural calculi was observed, and 24-hour urine samples were collected from patients during follow-up at 4 weeks after surgery to detect urine pH, levels of uric acid, oxalic acid and citric acid and concentrations of calcium and phosphorus ions. The differences in occurrence of ureteral stent calculi and urine detection indicators were compared between the two groups.
Results In treatment group, 42 cases were enrolled but 2 cases were lost to follow-up, and 40 cases were finally included for statistical analysis. In control group, 43 patients were included but 3 patients were lost to follow-up, thus 40 patients were enrolled for statistical analysis. Ureteral stents were removed at 4 weeks or 8 weeks after surgery in both groups. The treatment group had a total of 64 ureteral stent tubes retained, and the incidence rate of stent mural calculi was 1.56% (1 case/64 cases). The control group had a total of 62 ureteral stent tubes retained, and the incidence rate of stent mural calculi was 11.29% (7 cases/62 cases, P<0.05). At 4 weeks after surgery, the calcium ion concentrations in treatment group and control group were (2.63±0.66) and (3.45±1.02) mmol·L-1, oxalic acid levels were (0.41±0.04) and (0.52±0.07) mmol·L-1, phosphorus ion concentrations were (12.36±2.38) and (16.01±2.16) mmol·L-1, uric acid levels were (2.02±0.17) and (2.43±0.23) mmol·L-1, urine pH values were 6.85±0.34 and 6.24±0.34, urine citric acid levels were (1.61±0.22) and (1.39±0.17) mmol·L-1, respectively (all P<0.05). The adverse drug reactions in treatment group during medication included nausea and diarrhea, with a total incidence rate of 10.00% (4 cases/40 cases). No adverse drug reactions were observed in the control group.
Conclusion Potassium citrate sustained-release tablets can reduce the incidence rate of stent mural calculi after ureteral lithotripsy for upper urinary tract calculi, and lower the concentrations of urinary calcium ion and oxalic acid.
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目的 分析枸橼酸钾缓释片对上尿路结石输尿管碎石术后支架管附壁结石的预防效果及对尿钙离子、尿草酸浓度的影响。
方法 将进行输尿管碎石术的上尿路结石患者随机分为对照组与试验组。2组患者术后均常规进行饮食指导和健康教育，对照组术后给予常规抗感染、止痛、排石治疗，试验组术后在对照组的基础上给予枸橼酸钾缓释片，每次1.08 g，每天3次，口服，连续服用至输尿管支架管拔除。分别于术后4周或8周根据患者恢复情况拔除输尿管支架管，观察支架附壁结石发生情况，并于术后4周随访时收集患者的24 h尿液标本，检测尿液pH值、尿酸、草酸、枸橼酸水平及钙、磷离子浓度，比较2组输尿管支架结石发生情况及尿液检测指标的差异。
结果 试验组入组42例，失访2例，最终有40例纳入统计分析；对照组入组43例，失访3例，最终有40例纳入统计分析，2组患者均于术后4周或8周拔除输尿管支架。试验组共留置64根输尿管支架管，支架管附壁结石发生率为1.56%（1例/64例），对照组共留置62根输尿管支架管，支架管附壁结石发生率为11.29%（7例/62例），2组比较，在统计学上差异有统计学意义（P<0.05）。术后4周时，试验组和对照组的钙离子水平分别为（2.63±0.66）和（3.45±1.02）mmol·L-1，草酸水平分别为（0.41±0.04）和（0.52±0.07）mmol·L-1，磷离子水平分别为（12.36±2.38）和（16.01±2.16）mmol·L-1，尿酸水平分别为（2.02±0.17）和（2.43±0.23）mmol·L-1，尿pH水平分别为6.85±0.34和6.24±0.34，尿枸橼酸水平分别为（1.61±0.22）和（1.39±0.17）mmol·L-1，2组间比较在统计学上差异均有统计学意义（均P<0.05）。试验组患者发生的药物不良反应包括恶心、腹泻，总发生率为10.00%（4例/40例）。对照组未见药物不良反应发生。
结论 枸橼酸钾缓释片可降低上尿路结石输尿管碎石术后支架管附壁结石发生率，降低患者尿钙离子及尿草酸浓度。
, authors=吴卓, 范帅帅, 问晓东, authorsList=吴卓, 范帅帅, 问晓东, authorCompany=null, correspAuthors=吴卓, authorNote=
吴卓（1986-），男，主治医师，主要从事泌尿系统结石及男科疾病的诊断与治疗方面的研究
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吴卓（1986-），男，主治医师，主要从事泌尿系统结石及男科疾病的诊断与治疗方面的研究
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吴卓（1986-），男，主治医师，主要从事泌尿系统结石及男科疾病的诊断与治疗方面的研究
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