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Article(id=1291404882649543260, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729094400000, receivedDateStr=2024-10-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824517165, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824517165, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824517165, creator=13701087609, updateTime=1785824517165, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1191, endPage=1195, ext={EN=ArticleExt(id=1291404882829898333, articleId=1291404882649543260, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Surgery, chemoradiotherapy are the conventional methods of clinical treatment of tumor, due to adverse reactions, drug resistance and other problems, the prognosis and survival are poor. Due to its characteristics of stable action with little toxic side effects and multi-channel and multi-target comprehensive regulation, traditional Chinese medicine has been widely concerned and recognized in anti-tumor. Autophagy and apoptosis are two ways of programmed cell death, and the interaction between autophagy and apoptosis is crucial to the overall fate of cancer cells. The balance between autophagy and apoptosis contains the theory of Yin and Yang in traditional Chinese medicine, and has become an effective strategy for clinical treatment of cancer. This study summarized the mechanism of the signaling pathway involved in the regulation of autophagy and apoptosis balance and thus effectively inhibited the pathological process of tumors, in order to provide pharmacological basis and scientific reference for the development and clinical application of traditional Chinese medicine anti-tumor drugs.

, authors=Ding-cai MA1a, 1b, Mao-mao WANG1a, 1b, Zhe WANG1a, 1b, Yu-gui ZHANG1a, 1b, Ting LIU1a, 1b, Fei-yun GAO1a, 1b, Yan-jun WANG1a, 1b, Zhuan-hong ZHANG1a, 1b, Yue-feng LI1b, authorsList=Ding-cai MA, Mao-mao WANG, Zhe WANG, Yu-gui ZHANG, Ting LIU, Fei-yun GAO, Yan-jun WANG, Zhuan-hong ZHANG, Yue-feng LI, authorCompany=null, correspAuthors=Yue-feng LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404883152859742, articleId=1291404882649543260, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

手术、放化疗是临床治疗肿瘤的常规方法，由于药物不良反应、耐药性等问题，预后和生存较差。中药因其作用平稳、药物不良反应小、多途径多靶点综合调控的特点，在抗肿瘤方面受到广泛的关注与认可。细胞自噬与凋亡是细胞程序性死亡的2种方式，自噬和凋亡的相互作用对于癌细胞的整体命运至关重要。自噬-凋亡平衡蕴含着中医阴阳理论，其已成为临床治疗肿瘤的有效策略。本研究就信号通路参与自噬-凋亡平衡的调控作用进而有效抑制肿瘤病理进程的作用机制进行总结，以期为中药抗肿瘤药物研发和临床应用提供药理学依据和科学参考。

, authors=马定财1a, 1b, 王毛毛1a, 1b, 王哲1a, 1b, 张育贵1a, 1b, 刘婷1a, 1b, 高飞云1a, 1b, 王彦钧1a, 1b, 张转红1a, 1b, 李越峰1b, authorsList=马定财, 王毛毛, 王哲, 张育贵, 刘婷, 高飞云, 王彦钧, 张转红, 李越峰, authorCompany=null, correspAuthors=李越峰, authorNote=

马定财（1997-），男，硕士研究生，主要从事中药及复方加工炮制机制及活性成分的相关研究

, correspAuthorsNote=
李越峰，教授，博士生导师 Tel: （0931）5109762 E-mail:
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马定财（1997-），男，硕士研究生，主要从事中药及复方加工炮制机制及活性成分的相关研究

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马定财（1997-），男，硕士研究生，主要从事中药及复方加工炮制机制及活性成分的相关研究

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中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状
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马定财 1a, 1b , 王毛毛 1a, 1b , 王哲 1a, 1b , 张育贵 1a, 1b , 刘婷 1a, 1b , 高飞云 1a, 1b , 王彦钧 1a, 1b , 张转红 1a, 1b , 李越峰 1b
中国临床药理学杂志 | 综述 2025,41(8): 1191-1195
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中国临床药理学杂志 |综述 2025 , 41 (8) : 1191 -1195
中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状
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马定财1a, 1b, 王毛毛1a, 1b, 王哲1a, 1b, 张育贵1a, 1b, 刘婷1a, 1b, 高飞云1a, 1b, 王彦钧1a, 1b, 张转红1a, 1b, 李越峰1b
作者信息
  • 1a.甘肃中医药大学，药学院，甘肃 兰州 730000
  • 1b.甘肃中医药大学，科研实验中心，甘肃 兰州 730000
通讯作者:
李越峰，教授，博士生导师 Tel: （0931）5109762 E-mail:
作者简介:

马定财（1997-），男，硕士研究生，主要从事中药及复方加工炮制机制及活性成分的相关研究

Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways
Ding-cai MA1a, 1b, Mao-mao WANG1a, 1b, Zhe WANG1a, 1b, Yu-gui ZHANG1a, 1b, Ting LIU1a, 1b, Fei-yun GAO1a, 1b, Yan-jun WANG1a, 1b, Zhuan-hong ZHANG1a, 1b, Yue-feng LI1b
Affiliations
  • 1a.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 1b.Scientific Researsh and Experimental Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
出版时间: 2025-04-28 doi: 10.13699/j.cnki.1001-6821.2025.08.025
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手术、放化疗是临床治疗肿瘤的常规方法，由于药物不良反应、耐药性等问题，预后和生存较差。中药因其作用平稳、药物不良反应小、多途径多靶点综合调控的特点，在抗肿瘤方面受到广泛的关注与认可。细胞自噬与凋亡是细胞程序性死亡的2种方式，自噬和凋亡的相互作用对于癌细胞的整体命运至关重要。自噬-凋亡平衡蕴含着中医阴阳理论，其已成为临床治疗肿瘤的有效策略。本研究就信号通路参与自噬-凋亡平衡的调控作用进而有效抑制肿瘤病理进程的作用机制进行总结，以期为中药抗肿瘤药物研发和临床应用提供药理学依据和科学参考。

中药  /  信号通路  /  自噬-凋亡平衡  /  抗肿瘤

Surgery, chemoradiotherapy are the conventional methods of clinical treatment of tumor, due to adverse reactions, drug resistance and other problems, the prognosis and survival are poor. Due to its characteristics of stable action with little toxic side effects and multi-channel and multi-target comprehensive regulation, traditional Chinese medicine has been widely concerned and recognized in anti-tumor. Autophagy and apoptosis are two ways of programmed cell death, and the interaction between autophagy and apoptosis is crucial to the overall fate of cancer cells. The balance between autophagy and apoptosis contains the theory of Yin and Yang in traditional Chinese medicine, and has become an effective strategy for clinical treatment of cancer. This study summarized the mechanism of the signaling pathway involved in the regulation of autophagy and apoptosis balance and thus effectively inhibited the pathological process of tumors, in order to provide pharmacological basis and scientific reference for the development and clinical application of traditional Chinese medicine anti-tumor drugs.

traditional Chinese medicine  /  signaling pathway  /  autophagy and apoptosis balance  /  anti-tumor
马定财, 王毛毛, 王哲, 张育贵, 刘婷, 高飞云, 王彦钧, 张转红, 李越峰. 中药调控自噬-凋亡平衡相关信号通路抗肿瘤作用的研究现状. 中国临床药理学杂志, 2025 , 41 (8) : 1191 -1195 . DOI: 10.13699/j.cnki.1001-6821.2025.08.025
Ding-cai MA, Mao-mao WANG, Zhe WANG, Yu-gui ZHANG, Ting LIU, Fei-yun GAO, Yan-jun WANG, Zhuan-hong ZHANG, Yue-feng LI. Research status of the antitumor effects of traditional Chinese medicine on regulating autophagy and apoptosis balance related signaling pathways[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (8) : 1191 -1195 . DOI: 10.13699/j.cnki.1001-6821.2025.08.025
基金
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  • 国家自然科学基金资助项目(82160750; 81960713)
  • 甘肃省人才重点项目（中药炮制技术传承创新团队建设与示范推广）
  • 甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-21)
  • 甘肃省科学技术厅-科技计划（创新基地与人才计划）基础研究创新群体基金资助项目(21JR7RA569)
  • 甘肃省联合科研基金资助项目(2024CYZC-41)
  • 高校产业支撑基金资助项目(24JRRA882)
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2025年第41卷第8期
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doi: 10.13699/j.cnki.1001-6821.2025.08.025
  • 接收时间：2024-10-17
  • 首发时间：2026-08-04
  • 出版时间：2025-04-28
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  • 收稿日期：2024-10-17
基金
国家自然科学基金资助项目(82160750; 81960713)
甘肃省人才重点项目（中药炮制技术传承创新团队建设与示范推广）
甘肃省教育厅产业支撑计划基金资助项目(2021CYZC-21)
甘肃省科学技术厅-科技计划（创新基地与人才计划）基础研究创新群体基金资助项目(21JR7RA569)
甘肃省联合科研基金资助项目(2024CYZC-41)
高校产业支撑基金资助项目(24JRRA882)
作者信息
    1a.甘肃中医药大学，药学院，甘肃 兰州 730000
    1b.甘肃中医药大学，科研实验中心，甘肃 兰州 730000

通讯作者:

李越峰，教授，博士生导师 Tel: （0931）5109762 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.08.025
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2种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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