中国临床药理学杂志

阿魏酸哌嗪联合连续性肾替代疗法治疗急性肾衰竭患儿的临床研究

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柴彦艳 ^1a^,² , 盛瑶 ^1a , 金丹群 ^1a , 童文佳 ^1a , 王云 ^1a , 邓芳 ^1b^,²

中国临床药理学杂志 | 临床与基础桥接研究 2025,41(11): 1501-1505

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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (11) : 1501 -1505

阿魏酸哌嗪联合连续性肾替代疗法治疗急性肾衰竭患儿的临床研究

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柴彦艳^1a^,², 盛瑶^1a, 金丹群^1a, 童文佳^1a, 王云^1a, 邓芳^1b^,²

作者信息

^1a.安徽医科大学附属省儿童医院，重症医学科，安徽合肥 230022

^1b.安徽医科大学附属省儿童医院，肾内科，安徽合肥 230022

^2.安徽医科大学第五临床学院，安徽合肥 230022

通讯作者:

邓芳，主任医师，博士生导师 MP: 18805575228 E-mail: dengfang@ahmu.edu.cn

作者简介:

柴彦艳（1979-），女，硕士研究生，副主任医师，主要从事儿童重症医学方向的临床诊疗工作

Clinical trial of piperazine ferulate combined with continuous renal replacement therapy in the treatment of children with acute renal failure

Yan-yan CHAI^1a^,², Yao SHENG^1a, Dan-qun JIN^1a, Wen-jia TONG^1a, Yun WANG^1a, Fang DENG^1b^,²

Affiliations

^1a.Department of Critical Care Medicine, Provincial Children’s Hospital Affiliated to Anhui Medical University, Hefei 230022, Anhui Province, China

^1b.Department of Nephrology, Provincial Children’s Hospital Affiliated to Anhui Medical University, Hefei 230022, Anhui Province, China

^2.The Fifth Clinical College, Anhui Medical University, Hefei 230022, Anhui Province, China

出版时间: 2025-06-17 doi: 10.13699/j.cnki.1001-6821.2025.11.001

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摘要

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目的

观察阿魏酸哌嗪片联合连续性肾替代疗法治疗急性肾衰竭患儿的临床疗效及安全性。

方法

将急性肾衰竭患儿随机分为对照组和试验组。2组患儿均给予基础治疗，在此基础上，对照组给予连续性肾替代疗法；试验组在对照组治疗的基础上，联合阿魏酸哌嗪片每次100 mg，口服，tid。2组患儿均治疗2周。比较2组患儿的临床疗效、肾功能、肾损伤标志物水平，以及安全性。

结果

试验组入组85例，脱落2例，最终有83例纳入统计分析；对照组入组84例，脱落3例，最终有81例纳入统计分析。治疗后，试验组和对照组的总有效率分别为92.77%（77例/83例）和81.48%（66例/81例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的血清肌酸酐水平分别为（120.35±17.12）和（148.12±20.03）μmoL·L^-1，血尿素氮水平分别为（12.29±2.14）和（15.64±3.01）μmoL·L^-1，β2-微球蛋白含量分别为（1.87±0.25）和（2.14±0.39）mg·L^-1，24 h尿蛋白定量分别为（0.94±0.31）和（1.24±0.47）g·24 h^-1，N-乙酰-β-D-葡萄糖苷酶含量分别为（17.03±2.98）和（20.36±3.51）U·L^-1，肾损伤分子1含量分别为（1.62±0.27）和（2.09±0.32）μg·L^-1，中性粒细胞明胶酶相关脂质运载蛋白含量分别为（50.36±8.13）和（59.23±10.14）μg·L^-1，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有恶心、呕吐、腹胀，对照组的药物不良反应主要有头晕、恶心、呕吐。试验组和对照组的总药物不良反应发生率分别为7.23%和4.94%，在统计学上差异无统计学意义（P>0.05）。

结论

阿魏酸哌嗪片联合连续性肾替代疗法治疗急性肾衰竭患儿的临床疗效显著，其能够显著改善患儿的肾功能，减轻肾损伤，且不增加药物不良反应的发生率。

关键词

阿魏酸哌嗪片 / 连续性肾替代疗法 / 急性肾衰竭 / 临床疗效 / 安全性评价

Abstract

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Objective

To observe the clinical efficacy and safety of ferulic acid piperazine tablets combined with continuous renal replacement therapy in the treatment of children with acute renal failure.

Methods

Children with acute renal failure were randomly divided into control group and treatment group. Both groups were given basic treatment, based on which, the control group was given continuous renal replacement therapy; the treatment group was given piperazine ferulate tablets 100 mg per time, orally, tid, on the basis of control group. Two groups were treated for 2 weeks. The clinical efficacy, renal function, levels of renal injury markers and safety were compared between the two groups.

Results

Treatment group was enrolled 85 cases, 2 cases dropped out, and 83 cases were finally included in the statistical analysis. Control group was enrolled 84 cases, 3 cases dropped out, and 81 cases were finally included in the statistical analysis. After treatment, the total effective rates of treatment and control groups were 92.77% (77 cases/83 cases) and 81.48% (66 cases / 81 cases) with statistically significant difference (P<0.05). After treatment, the serum creatinine levels of treatment and control groups were (120.35±17.12) and (148.12±20.03) μmoL·L^-1; the blood urea nitrogen levels were (12.29±2.14) and (15.64±3.01) μmoL·L^-1; the β2-microglobulin levels were (1.87±0.25) and (2.14±0.39) mg·L^-1; the 24-h urinary protein quantification were (0.94±0.31) and (1.24±0.47) g·24 h^-1; N-acetyl-β-D-glucosidase contents were (17.03±2.98) and (20.36±3.51) U·L^-1; the renal injury molecule 1 contents were (1.62±0.27) and (2.09±0.32) μg·L^-1; the neutrophil gelatinase-associated lipid transport protein contents were (50.36±8.13) and (59.23±10.14) μg·L^-1, respectively, and the differences were all statistically significant (all P<0.05). The adverse drug reactions of treatment group were nausea, vomiting and abdominal distension, while those in the control group were dizziness, nausea and vomiting. The total incidences of adverse drug reactions in the treatment and control groups were 7.23% and 4.94% without significant difference (P>0.05).

Conclusion

Ferulic acid piperazine tablets combined with continuous renal replacement therapy have definitive clinical efficacy in the treatment of children with acute renal failure, which can significantly improve the renal function of children, reduce renal injury, without increasing the incidence of adverse drug reactions.

Key words

piperazine ferulate tablet / continuous renal replacement therapy / acute renal failure / clinical effect / safety evaluation

引用本文

柴彦艳, 盛瑶, 金丹群, 童文佳, 王云, 邓芳. 阿魏酸哌嗪联合连续性肾替代疗法治疗急性肾衰竭患儿的临床研究. 中国临床药理学杂志, 2025 , 41 (11) : 1501 -1505 . DOI: 10.13699/j.cnki.1001-6821.2025.11.001

Yan-yan CHAI, Yao SHENG, Dan-qun JIN, Wen-jia TONG, Yun WANG, Fang DENG. Clinical trial of piperazine ferulate combined with continuous renal replacement therapy in the treatment of children with acute renal failure[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (11) : 1501 -1505 . DOI: 10.13699/j.cnki.1001-6821.2025.11.001

基金

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安徽省临床医学研究转化专项基金资助项目(202304295107020063)

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2025年第41卷第11期

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doi: 10.13699/j.cnki.1001-6821.2025.11.001

接收时间：2024-12-30
首发时间：2026-08-04
出版时间：2025-06-17

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收稿日期：2024-12-30

基金

安徽省临床医学研究转化专项基金资助项目(202304295107020063)

作者信息

^1a.安徽医科大学附属省儿童医院，重症医学科，安徽合肥 230022

^1b.安徽医科大学附属省儿童医院，肾内科，安徽合肥 230022

^2.安徽医科大学第五临床学院，安徽合肥 230022

通讯作者:

邓芳，主任医师，博士生导师 MP: 18805575228 E-mail: dengfang@ahmu.edu.cn

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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.11.001

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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