Article(id=1291404851922067581, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730217600000, receivedDateStr=2024-10-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824509839, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824509839, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824509839, creator=13701087609, updateTime=1785824509839, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1126, endPage=1131, ext={EN=ArticleExt(id=1291404852165337214, articleId=1291404851922067581, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Icariin on immune regulation and TLR4 signaling pathway in mice with recurrent abortion, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the protective effect of icariin on recurrent spontaneous abortion (RSA) mice and its potential mechanism.
Methods Female CBA/J mice were randomly divided into control group (mated with male BALB/c mice), model group (modeling mating with male DBA/2 mice), experimental-L group (after modeling, 25.00 mg·kg-1 icariin was given by intragastric administration), experimental-H group (50.00 mg·kg-1 icariin was given by intragastric administration after modeling), positive group (2.6 mg·kg-1 desdrogesterone was given by intragastream after modeling), uterine tissue was collected after 14 days of treatment for follow-up experiments. Embryo absorption rate was observed and recorded. The levels of interleukin (IL) -4 and interferon γ (IFN-γ) were detected by enzyme linked immunosorbent assay (ELISA). The mRNA expressions of Foxp3 and Toll-like receptor 4 (TLR4) were detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR). Western blot assay was used to detect the expression of TLR4 and phosphorylated nuclear transcription factor-κB (p-NF-κB) protein.
Results The absorption rates of mouse embryos in control group, model group, experimental-L group, experimental-H group and positive group were 7.37% (7 cases/95 cases), 37.33% (28 cases/75 cases), 20.93% (18 cases/86 cases), 13.79% (12 cases/87 cases) and 12.22% (11 cases/90 cases), respectively; IL-4 expression levels were (33.84±5.71), (10.71±2.34), (16.86±1.13), (26.91±3.04) and (19.56±1.79) pg·mL-1, respectively; the expression levels of IFN-γ were (25.97±1.40), (63.38±5.39), (47.23±6.78) (34.80±4.08) and (29.61±3.25) pg·mL-1, respectively; the relative expression levels of Foxp3 mRNA were 1.00±0.07, 0.57±0.05, 0.72±0.06, 0.90±0.05 and 0.66±0.06, respectively; the relative expression levels of TLR4 mRNA were 1.00±0.10, 2.32±0.17, 1.78±0.14, 1.40±0.08 and 2.05±0.26, respectively; the relative expression levels of TLR4 protein were 0.31±0.05, 0.90±0.11, 0.68±0.05, 0.55±0.05 and 0.79±0.10, respectively; the relative expression levels of p-NF-κB protein were 0.27±0.02, 0.82±0.13, 0.66±0.04, 0.42±0.05 and 0.75±0.09, respectively. The above indicators in the model group compared with the control group, the experimental-L and experimental-H groups were compared with the model group, and the differences were statistically significant (all P<0.05).
Conclusion Icariin may play a protective role in improving RSA immune response by inhibiting TLR4/NF-κB pathway.
, authors=Jin-fen LI
1, Jun-jiang ZHU
2, Yuan-yuan LIU
1, Ji LUO
1, Xu-hui LIANG
1, Jian-ying XIAO
1, authorsList=Jin-fen LI, Jun-jiang ZHU, Yuan-yuan LIU, Ji LUO, Xu-hui LIANG, Jian-ying XIAO, authorCompany=null, correspAuthors=Jian-ying XIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404852521853055, articleId=1291404851922067581, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=淫羊藿苷对复发性流产小鼠免疫调节作用及TLR4信号通路的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨淫羊藿苷对复发性自然流产（RSA）小鼠的保护作用及其潜在作用机制。
方法 将雌性CBA/J小鼠随机分为对照组（与雄性BALB/c小鼠交配）、模型组（与雄性DBA/2小鼠交配建模）、低剂量实验组（模型组的基础上灌胃给予25.00 mg·kg-1的淫羊藿苷）、高剂量实验组（模型组的基础上灌胃给予50.00 mg·kg-1的淫羊藿苷）、阳性药物组（模型组的基础上灌胃给予2.6 mg·kg-1的地屈孕酮），治疗14 d后收集子宫组织进行后续实验。观察和记录胚胎吸收率，用酶联免疫吸附试验法检测白细胞介素（IL）-4和干扰素γ（IFN-γ）水平，用实时荧光定量聚合酶链反应实验检测叉头蛋白P3（Foxp3）和Toll样受体4（TLR4）mRNA的表达水平，用蛋白质印迹法检测TLR4和磷酸化核转录因子-κB（p-NF-κB）蛋白的表达水平。
结果 对照组、模型组、低剂量实验组、高剂量实验组和阳性药物组的胚胎吸收率分别为7.37%（7只/95只）、37.33%（28只/75只）、20.93%（18只/86只）、13.79%（12只/87只）和12.22%（11只/90只），IL-4水平分别为（33.84±5.71）、（10.71±2.34）、（16.86±1.13）、（26.91±3.04）和（19.56±1.79）pg·mL-1，IFN-γ水平分别为（25.97±1.40）（63.38±5.39）、（47.23±6.78）（34.80±4.08）和（29.61±3.25）pg·mL-1，Foxp3 mRNA相对表达水平分别为1.00±0.07、0.57±0.05、0.72±0.06、0.90±0.05和0.66±0.06，TLR4 mRNA相对表达水平分别为1.00±0.10、2.32±0.17、1.78±0.14、1.40±0.08和2.05±0.26，TLR4蛋白相对表达水平分别为0.31±0.05、0.90±0.11、0.68±0.05、0.55±0.05和0.79±0.10，p-NF-κB蛋白相对表达水平分别为0.27±0.02、0.82±0.13、0.66±0.04、0.42±0.05和0.75±0.09。模型组的上述指标与对照组比较，低、高剂量实验组的上述指标分别与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 淫羊藿苷可能通过抑制TLR4/NF-κB通路改善RSA免疫应答活性来发挥保护作用。
, authors=李金芬
1, 朱俊江
2, 刘媛媛
1, 罗吉
1, 梁旭晖
1, 肖建英
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李金芬（1974-），女，副主任医师，主要从事妊娠合并风湿免疫系统疾病方面的临床诊疗工作
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