Article(id=1291404839951528192, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733760000000, receivedDateStr=2024-12-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824506985, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824506985, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824506985, creator=13701087609, updateTime=1785824506985, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1634, endPage=1640, ext={EN=ArticleExt(id=1291404841499226369, articleId=1291404839951528192, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of traditional Chinese medicine intervention in mTOR signaling pathway in the treatment of osteoarthritis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Osteoarthritis (OA) is a prevalent chronic degenerative condition in clinical settings, marked by a prolonged disease course and unfavorable prognosis. It imposes a substantial burden on both society and affected families. Chondrocyte apoptosis is a typical pathological manifestation of OA cartilage degeneration, and autophagy is a biological process in which cells are induced by various stressors to activate the lysosomal degradation pathway, selectively degrade and remove the organelles and protein aggregates damaged by internal aging, so as to maintain their own homeostasis. The mammalian target of rapamycin (mTOR)-related signaling pathway is an important regulatory pathway for autophagy. The mTOR signaling pathway is involved in the physiological and pathological processes such as apoptosis and autophagy of OA chondrocytes, and is one of the important targets for the study of OA at home and abroad. Based on the relevant literature in recent years, this paper summarizes the specific role of mTOR in the development of OA and the mechanism of action of traditional Chinese medicine in regulating the mTOR signaling pathway in the prevention and treatment of OA.

, authors=Hao-fei YANG¹, Jin-sheng LI¹, Xu-sheng ZHANG¹, Zhen-hua SHI¹, Xu-dong ZHU¹, Xun-ru ZHANG¹, Hai-ping LIU², authorsList=Hao-fei YANG, Jin-sheng LI, Xu-sheng ZHANG, Zhen-hua SHI, Xu-dong ZHU, Xun-ru ZHANG, Hai-ping LIU, authorCompany=null, correspAuthors=Hai-ping LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404841901879554, articleId=1291404839951528192, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药干预mTOR信号通路治疗骨性关节炎的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

骨性关节炎（OA）为临床常见的慢性退行性疾病，病程长预后差，给社会和家庭带来沉重负担。软骨细胞凋亡是OA软骨退变的典型病理表现，细胞自噬受应激源诱导后激活溶酶体降解途径，降解并清除内部老化受损的细胞器及蛋白聚集体，从而维持自身稳态。哺乳动物西罗莫司靶蛋白（mTOR）相关信号通路是自噬的重要调控途径，mTOR信号通路参与OA软骨细胞凋亡和自噬等生理病理进程，是目前国内外研究OA的重要靶点之一。本文基于近年相关文献，总结了mTOR在OA发展中的具体作用及中药调节mTOR信号通路防治OA的作用机制。

, authors=杨昊飞¹, 李金生¹, 张旭升¹, 史振华¹, 朱旭东¹, 张循儒¹, 柳海平², authorsList=杨昊飞, 李金生, 张旭升, 史振华, 朱旭东, 张循儒, 柳海平, authorCompany=null, correspAuthors=柳海平, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=nKS9URdyYEBUxE5a4A0P2w==, magXml=Of+/Y9d0sylRp/xlj0IUfQ==, pdfUrl=null, pdf=VoogEge1zQSdEWSUNNPtxQ==, pdfFileSize=882000, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Nn5h4vl0y2ogbyuETytAvg==, mapNumber=null, fund=null)}, authors=[Author(id=1291404842413584650, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404839951528192, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404842497470732, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404839951528192, authorId=1291404842413584650, language=EN, stringName=Hao-fei YANG, firstName=Hao-fei, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.Clinical College of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404842728157453, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404839951528192, authorId=1291404842413584650, language=CN, stringName=杨昊飞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.甘肃中医药大学 中医临床学院，甘肃 兰州 730000, bio={"content":"

杨昊飞（1996-），男，硕士研究生，主要从事中医药防治骨伤科疾病的相关研究

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杨昊飞（1996-），男，硕士研究生，主要从事中医药防治骨伤科疾病的相关研究

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