Article(id=1291404833622315437, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728748800000, receivedDateStr=2024-10-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824505476, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824505476, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824505476, creator=13701087609, updateTime=1785824505476, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1026, endPage=1031, ext={EN=ArticleExt(id=1291404834360512942, articleId=1291404833622315437, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of pyroptosis in rheumatoid arthritis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Pyroptosis plays an important role in the development of rheumatoid arthritis (RA) and the molecules involved in the pyroptosis pathway can influence the course of RA. Therefore, inhibition of pyroptosis may be an effective therapeutic strategy to slow down the development of RA. In this paper, we systematically reviewed the relationship between pyroptosis and RA, explored the mechanism of pyroptosis in RA from three aspects: nucleotide oligomerisation structural domain-like receptor protein 3 inflammatory vesicles, Gasdermin family of proteins and inflammatory cytokines, and revealed how the relevant molecules in the pyroptosis pathway contribute to inflammatory responses and intercellular signalling, thereby exacerbating the progression of RA. The aim of this review is to provide a theoretical basis for the study of the pathological mechanisms of RA and the development of therapeutic drugs for RA that target the inhibition of pyroptosis.

, authors=Yue-ya ZHU¹, Zhi PAN¹, Ying-hang WANG², authorsList=Yue-ya ZHU, Zhi PAN, Ying-hang WANG, authorCompany=null, correspAuthors=Ying-hang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404834985464239, articleId=1291404833622315437, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=类风湿关节炎中细胞焦亡的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

细胞焦亡在类风湿关节炎（RA）的发生发展中起着重要作用，细胞焦亡通路中的相关分子会影响RA的病程。因此，抑制细胞焦亡可能成为延缓RA发展的有效治疗策略。本文系统阐述了细胞焦亡与RA之间的关系，从核苷酸寡聚化结构域样受体蛋白3炎症小体、Gasdermin蛋白家族及炎症细胞因子3个方面探讨细胞焦亡在RA中作用机制，揭示细胞焦亡通路中的相关分子是如何促进炎症反应和细胞间信号转导，从而加剧RA的发展。本综述旨在为RA的病理机制研究及开发针对抑制细胞焦亡的RA治疗药物提供理论基础。

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朱跃亚（2000-），女，硕士研究生，主要从事药效物质基础与机制研究

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朱跃亚（2000-），女，硕士研究生，主要从事药效物质基础与机制研究

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