Article(id=1291404825208541566, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729008000000, receivedDateStr=2024-10-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824503471, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824503471, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824503470, creator=13701087609, updateTime=1785824503470, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=943, endPage=948, ext={EN=ArticleExt(id=1291404825971904895, articleId=1291404825208541566, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Based on metabolomics to explore the mechanism of Jianpi Yishentongqiao granule in the intervention of spleen-kidney Yang deficiency type allergic rhinitis rats, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the mechanism of Jianpi Yishentongqiao granule (JPYSTQG) in the intervention of spleen-kidney Yang deficiency type allergic rhinitis (AR) rats based on metabolomics.
Methods The AR rat model of spleen-kidney-yang deficiency type was constructed by ovalbumin intraperitoneal injection sensitization + hydrocortisone intraperitoneal injection + rhubarb irrigation combined with modeling, and was randomly divided into model group and experimental group, with 10 rats in each group. Another 10 normal rats were selected as blank group. The experimental group was given 472.5 mg·mL-1 JPYSTQG solution, the blank group and model group were given equal volume 0.9% NaCl. The rats in the three groups were administrated by gavage three times a day for 14 days. Serum levels of interleukin-4 (IL-4), immunoglobulin E (IgE) and interferon-γ (IFN-γ) were detected by enzyme-linked immunosorbent assay. Differential metabolites were screened by metabolomics and enriched by Kyoto Encyclopedia of Genes and Genomes.
Results The serum IgE levels in experimental, model and blank groups were (21.23±0.40), (23.80±0.67) and (20.03±1.42) ng·mL-1; IL-4 levels were (111.00±5.86), (119.79±7.07) and (99.24±1.03) pg·mL-1; IFN-γ levels were (1 980.63±15.63), (1 602.50±50.00) and (2 136.88±315.63) mg·mL-1, respectively. Compared with the model group, the differences of experimental and blank groups were statistically significant (all P<0.01). Thirty-seven potential biomarkers of JPYSTQG intervention in spleen-kidney-yang deficiency rats were screened, mainly through arginine biosynthesis and tumor-related pathways.
Conclusion JPYSTQG can regulate the expression of cytosine and other substances through arginine metabolism pathway, reduce IL-4, IgE and other inflammatory indicators, and thus have therapeutic effect on the allergic rhinitis rats with spleen-kidney-yang deficiency.
, authors=Si-chao ZHAO
1, Tong WU
1, Wen-rui YAN
1, Yong-qiang DUAN
1, Chang-xi ZHANG
2, authorsList=Si-chao ZHAO, Tong WU, Wen-rui YAN, Yong-qiang DUAN, Chang-xi ZHANG, authorCompany=null, correspAuthors=Chang-xi ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404827276333440, articleId=1291404825208541566, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于代谢组学探究健脾益肾通窍颗粒干预脾肾阳虚型过敏性鼻炎大鼠的作用机制, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 基于代谢组学探讨健脾益肾通窍颗粒（JPYSTQG）干预脾肾阳虚型过敏性鼻炎（AR）大鼠的机制。
方法 用腹腔注射卵蛋白致敏+氢化可的松+灌胃大黄水煎液溶液联合造模法构建脾肾阳虚型AR大鼠模型，并随机分为模型组和实验组，每组10只；另取10只正常大鼠作为空白组。实验组给予472.5 mg·mL-1 JPYSTQG溶液，空白组和模型组均给予等容量0.9% NaCl。3组大鼠每天灌胃给药3次，连续给药14 d。用酶联免疫吸附试验法检测血清中白细胞介素-4（IL-4）、免疫球蛋白E（IgE）和干扰素-γ（IFN-γ）水平，用代谢组学进行差异代谢物筛选，用京都基因和基因组百科全书对差异代谢物进行富集分析。
结果 实验组、模型组和空白组血清中IgE水平分别为（21.23±0.40）、（23.80±0.67）和（20.03±1.42）ng·mL-1，IL-4水平分别为（111.00±5.86）、（119.79±7.07）和（99.24±1.03）pg·mL-1，IFN-γ水平分别为（1 980.63±15.63）、（1 602.50±50.00）和（2 136.88±315.63）mg·mL-1。实验组和空白组的上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.01）。筛选出37种JPYSTQG干预脾肾阳虚大鼠的潜在生物标志物，主要通过精氨酸生物合成、肿瘤相关通路等途径发挥作用。
结论 JPYSTQG可以通过精氨酸代谢通路调控胞嘧啶等物质表达，降低IL-4、IgE等炎症因子表达水平，从而对脾肾阳虚型AR大鼠产生治疗作用。
, authors=赵思超
1, 吴桐
1, 闫文瑞
1, 段永强
1, 张常喜
2, authorsList=赵思超, 吴桐, 闫文瑞, 段永强, 张常喜, authorCompany=null, correspAuthors=张常喜, authorNote=
赵思超（1987-）男，主治医师，硕士研究生，主要研究中医药防治呼吸系统疾病的相关研究
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2.Department of Pulmonary Diseases, Hospital of Traditional Chinese Medicine and Research Institute of Traditional Chinese Medicine, Ningxia Hui Autonomous Region, Yinchuan 750011, Ningxia Hui Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404830531113375, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404825208541566, authorId=1291404830384312732, language=CN, stringName=张常喜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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