Article(id=1291404816140460886, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735142400000, receivedDateStr=2024-12-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824501309, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824501309, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824501308, creator=13701087609, updateTime=1785824501308, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1619, endPage=1623, ext={EN=ArticleExt(id=1291404816350176087, articleId=1291404816140460886, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on clinical application of targeted drugs in hepatocellular carcinoma, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Hepatocellular carcinoma (HCC) is the most common type of primary hepatocellular carcinoma, and advanced HCC is severe, difficult to treat, and has a poor prognosis. Since most patients have already lost the chance of surgery at the time of diagnosis, systemic drug therapy has become the main therapeutic tool. Currently, targeted therapeutic agents for advanced HCC are mainly divided into two categories: Tyrosine kinase inhibitors and vascular endothelial growth factor inhibitors. Approved tyrosine kinase inhibitors include sorafenib, lenvatinib, donafenib, regorafenib, cabozantinib and apatinib, etc. Vascular endothelial growth factor inhibitors include ramucirumab and bevacizumab. In recent years, the combination of targeted therapeutics and immune checkpoint inhibitors has effectively prolonged the overall survival of patients in several clinical trials, and this treatment model has become an important breakthrough in the current systemic treatment of advanced HCC. This article provides a brief introduction to the clinical application of targeted therapeutics for HCC.

, authors=Bo-zeng QIU^{1, 2}, Jun-li LIN¹, Jian-min GUO¹, Song-qiang XIE², Wei YANG¹, authorsList=Bo-zeng QIU, Jun-li LIN, Jian-min GUO, Song-qiang XIE, Wei YANG, authorCompany=null, correspAuthors=Wei YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404816702497624, articleId=1291404816140460886, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=肝细胞癌靶向药物临床应用的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

肝细胞癌（HCC）是最常见的原发性肝癌类型，晚期HCC病症严重，治疗难度大、预后差，由于多数患者确诊时已失去手术机会，系统性药物治疗成为主要的治疗手段。目前用于晚期HCC的靶向治疗药物主要分为酪氨酸激酶抑制药和血管内皮生长因子抑制药2类。已获批上市的酪氨酸激酶抑制药包括索拉非尼、仑伐替尼、多纳非尼、瑞戈非尼、卡博替尼和阿帕替尼等，血管内皮生长因子抑制药包括雷莫芦单抗和贝伐珠单抗。近年来，多项临床试验中靶向治疗药物与免疫检查点抑制药联合给药的治疗方案有效延长了患者的总生存期，这一治疗模式成为当前晚期HCC系统治疗的重要突破。本文对HCC靶向治疗药物的临床应用进行简要介绍。

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邱博增（1999- ），男，硕士研究生，主要从事靶向治疗药物的临床前研究

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邱博增（1999- ），男，硕士研究生，主要从事靶向治疗药物的临床前研究

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