Article(id=1291404815939137636, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1733760000000, receivedDateStr=2024-12-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824501260, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824501260, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824501260, creator=13701087609, updateTime=1785824501260, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1589, endPage=1594, ext={EN=ArticleExt(id=1291404816127881317, articleId=1291404815939137636, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Protective effects of curcumin on lung injury in rats with acute organophosphorus pesticide poisoning through the CytC/Apaf-1 pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of curcumin on lung injury in rats with acute organophosphorus pesticide poisoning (AOPP) through the cytochrome C/apoptotic protease activating factor-1 (CytC/Apaf-1) pathway.
Methods SD rats were divided into control group, model group, inhibitor group, experimental -L and experimental -H groups, with 10 rats in each group. Except for the control group, the rats in the other 4 groups were administrated with 20 mg·kg-1 oxomethoate to establish the rat model of organophosphorus pesticide poisoning. After the modeling was successful, the rats in the experimental -L and experimental -H groups were given 100 and 200 mg·kg-1 curcumin by intragastric administration, and the rats in the inhibitor group were given 67.8 mg·kg-1 YZ-488 intramuscularily, and the model group and control group were given equal volume of normal saline in the same way by intragastric administration and intramuscularily. Five groups of rats were given the drug once a day for 28 days. Mitochondrial membrane potential detection kits were applied to detect mitochondrial membrane potential (MMP). Enzyme-linked immunosorbent assay method was applied to detect levels of serum interleukin-10 (IL-10); apoptosis in lung tissue was detected by TUNEL; Western blot was applied to detect the expression levels of CytC and Apaf-1 proteins in lung tissue.
Results The MMP of experimental -L and experimental -H groups, control group, model group, and inhibitor group were (0.64±0.05), (0.78±0.09), (0.93±0.06), (0.51±0.04) and (0.76±0.08) RFU·mg-1, respectively; IL-10 levels were (67.58±6.82), (104.29±11.37), (148.62±13.54), (32.84±3.51) and (98.74±8.76) pg·mL-1, respectively; the apoptosis rates were (29.37±3.28)%, (16.58±1.87)%, (5.72±0.64)%, (43.68±4.91)% and (17.32±2.14)%, respectively; the relative expression levels of CytC protein were 0.89±0.07, 0.63±0.05, 0.42±0.04, 1.16±0.12 and 0.65±0.06, respectively; the relative expression levels of Apaf-1 protein were 0.73±0.06, 0.48±0.04, 0.32±0.03, 0.97±0.08 and 0.49±0.05, respectively. The above indexes of the model group were statistically significant compared with those in the experimental -L and experimental -H groups, inhibitor group and control group (all P<0.05).
Conclusion Curcumin may reduce inflammatory response and oxidative stress in rats by inhibiting the CytC/Apaf-1 pathway, alleviate lung tissue and mitochondrial structural damage, and thereby improve lung injury in rats with AOPP.
, authors=Shou-peng LI
1a, Feng-ying JIE
1b, Yi-heng JIN
1a, Lu-yu YANG
1b, authorsList=Shou-peng LI, Feng-ying JIE, Yi-heng JIN, Lu-yu YANG, authorCompany=null, correspAuthors=Lu-yu YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404816392122470, articleId=1291404815939137636, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=姜黄素通过CytC/Apaf-1通路对急性有机磷农药中毒大鼠肺损伤的保护作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨姜黄素通过细胞色素C/凋亡酶激活因子-1（CytC/Apaf-1）通路对急性有机磷农药中毒（AOPP）大鼠肺损伤的影响。
方法 将SD大鼠分为对照组、模型组、抑制药组和低、高剂量实验组，每组10只。除对照组外，其余4组大鼠通过灌胃20 mg·kg-1氧乐果建立有机磷农药中毒大鼠模型。造模成功后，低、高剂量实验组灌胃100、200 mg·kg-1姜黄素，抑制药组肌内注射67.8 mg·kg-1 ZYZ-488，模型组和对照组灌胃和肌内注射等体积0.9%NaCl。5组大鼠每天给药1次，连续给药28 d。用线粒体膜电位检测试剂盒检测线粒体膜电位（MMP），用酶联免疫吸附试验法检测血清白细胞介素-10（IL-10）水平，用TUNEL法检测肺组织细胞的凋亡情况，用蛋白质印迹法检测肺组织CytC和Apaf-1蛋白的表达水平。
结果 低、高剂量实验组、对照组、模型组和抑制药组的MMP分别为（0.64±0.05）、（0.78±0.09）、（0.93±0.06）、（0.51±0.04）和（0.76±0.08）RFU·mg-1，IL-10水平分别为（67.58±6.82）、（104.29±11.37）、（148.62±13.54）、（32.84±3.51）和（98.74±8.76）pg·mL-1，凋亡率分别为（29.37±3.28）%、（16.58±1.87）%、（5.72±0.64）%、（43.68±4.91）%和（17.32±2.14）%，CytC蛋白相对表达水平分别为0.89±0.07、0.63±0.05、0.42±0.04、1.16±0.12和0.65±0.06，Apaf-1蛋白相对表达水平分别为0.73±0.06、0.48±0.04、0.32±0.03、0.97±0.08和0.49±0.05。模型组的上述指标与低、高剂量实验组及抑制药组、对照组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 姜黄素可能通过抑制CytC/Apaf-1通路降低大鼠炎症反应和氧化应激，减轻肺组织和线粒体结构损坏，进而改善AOPP大鼠肺损伤。
, authors=李寿彭
1a, 揭凤英
1b, 金屹恒
1a, 杨璐瑜
1b, authorsList=李寿彭, 揭凤英, 金屹恒, 杨璐瑜, authorCompany=null, correspAuthors=杨璐瑜, authorNote=
李寿彭（1978- ），男，副主任医师，主要从事中毒、肺损伤、脓毒症的相关研究
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