Article(id=1291404807609246489, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404807152067353, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.08.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732118400000, receivedDateStr=2024-11-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824499275, onlineDateStr=2026-08-04, pubDate=1745769600000, pubDateStr=2025-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824499275, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824499275, creator=13701087609, updateTime=1785824499275, updator=13701087609, issue=Issue{id=1291404807152067353, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1745769600000', pubDateStr='2025-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824499166, creator='13701087609', updateTime=1785824499166, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1079, endPage=1084, ext={EN=ArticleExt(id=1291404807831544602, articleId=1291404807609246489, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of pyrotinib inducing ferroptosis in gastric cancer cells through
LncRNA SNHG16 regulation of the p53/SLC7A11 axis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of pyrotinib on ferroptosis in gastric cancer cells through the regulation of the tumor protein 53 (p53)/solute carrier family 7 member 11 (SLC7A11) axis by the long noncoding RNA small nucleolar RNA host gene 16 (LncRNA SNHG16).
Methods Human gastric cancer cells (NCI-N87) were selected and divided into NCI-N87 group (NCI-N87 cells were cultured normally without treatment), experimental group (NCI-N87 cells treated with 0.5 μmol·L-1 pyrotinib for 72 h), and oe-NC group (based on the transfection of oe-NC in experimental group), LncRNA SNHG16 group (based on experimental group transfected with oe-LncRNA SNHG16). Real-time fluorescence quantitative polymerase chain reaction and fluorescence in situ hybridisation were used to determine the expression level of LncRNA SNHG16, cell viability was detected by cell counting kit-8; invasive ability was detected by Transwell assay; reactive oxygen species (ROS) fluorescence level was detected by fluorescent probe staining of dihydroethidium (DHE); malondialdehyde (MDA) level and glutathione (GSH) activity were detected by kits; and the expression level of p53 and SLC7A11 protein was detected by Western blot.
Results The relative expression levels of LncRNA SNHG16 in the NCI-N87 group, the experimental group, the oe-NC group and the LncRNA SNHG16 group were 1.00±0.18, 0.39±0.06, 0.41±0.07 and 0.80±0.15, respectively; the relative fluorescence intensities of LncRNA SNHG16 were 1.00±0.16, 0.27±0.05, 0.23±0.04 and 0.81±0.17, respectively; the number of cell invasion was (82.16±14.67), (29.03±4.75), (31.82±5.69) and (74.98±11.34) pieces, respectively; the relative fluorescence levels of ROS were 1.00±0.15, 4.57±0.86, 3.95±0.61 and 1.54±0.33, respectively; MDA levels were (5.49±1.08), (11.27±1.93), (10.85±1.64) and (6.73±0.95) μmol·mg-1, respectively; GSH relative activities were 1.00±0.00, 0.54±0.09, 0.56±0.07 and 0.83±0.14, respectively; the relative expression levels of p53 protein were 1.00±0.17, 2.26±0.38, 1.98±0.32 and 1.24±0.19, respectively; the relative expression levels of SLC7A11 protein were 1.00±0.13, 0.34±0.05, 0.41±0.09 and 0.79±0.11, respectively. The differences in the above indicators between the NCI-N87 group and the experimental group, as well as between the oe-NC group and the LncRNA SNHG16 group, were all statistically significant (P<0.001).
Conclusion Pyrotinib can regulate the p53/SLC7A11 signaling pathway by inhibiting the expression of LncRNA SNHG16 to induce ferroptosis of gastric cancer cells and inhibit the proliferation and invasion of gastric cancer cells.
, authors=Cheng-yi LIU, Chan-chan HU, Qing-shan LI, Shuang ZHAO, Hui CHEN, Zhi-hui LI, Hai-jing JIAO, Ya-lan YIN, authorsList=Cheng-yi LIU, Chan-chan HU, Qing-shan LI, Shuang ZHAO, Hui CHEN, Zhi-hui LI, Hai-jing JIAO, Ya-lan YIN, authorCompany=null, correspAuthors=Chan-chan HU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404808292918043, articleId=1291404807609246489, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=吡咯替尼通过
LncRNA SNHG16调控p53/SLC7A11轴诱导胃癌细胞铁死亡的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究吡咯替尼通过长链非编码RNA小核仁RNA宿主基因16（LncRNA SNHG16）调控肿瘤蛋白53（p53）/溶质载体家族7成员11（SLC7A11）轴对胃癌细胞铁死亡的影响。
方法 将人胃癌细胞（NCI-N87）分为NCI-N87组（细胞正常培养不做处理）、实验组（0.5 μmol·L-1吡咯替尼处理72 h）、oe-NC组（基于实验组转染oe-NC）、LncRNA SNHG16组（基于实验组转染oe-LncRNA SNHG16）。用实时荧光定量聚合酶链反应和荧光原位杂交技术测定LncRNA SNHG16的表达水平，用细胞计数试剂盒-8实验法检测细胞活力，用Transwell小室实验检测细胞的侵袭能力，用二氢乙锭（DHE）荧光探针染色法检测活性氧（ROS）荧光水平，用试剂盒检测丙二醛（MDA）水平和谷胱甘肽（GSH）活性，用蛋白质印迹法检测p53和SLC7A11蛋白的相对表达水平。
结果 NCI-N87组、实验组、oe-NC组和LncRNA SNHG16组的LncRNA SNHG16相对表达水平分别为1.00±0.18、0.39±0.06、0.41±0.07和0.80±0.15，LncRNA SNHG16相对荧光强度分别为1.00±0.16、0.27±0.05、0.23±0.04和0.81±0.17，细胞侵袭数目分别为（82.16±14.67）、（29.03±4.75）、（31.82±5.69）和（74.98±11.34）个，ROS相对荧光水平分别为1.00±0.15、4.57±0.86、3.95±0.61和1.54±0.33，MDA水平分别为（5.49±1.08）、（11.27±1.93）、（10.85±1.64）和（6.73±0.95）μmol·mg-1，GSH相对活性分别为1.00±0.00、0.54±0.09、0.56±0.07和0.83±0.14，p53蛋白相对表达水平分别为1.00±0.17、2.26±0.38、1.98±0.32和1.24±0.19，SLC7A11蛋白相对表达水平分别为1.00±0.13、0.34±0.05、0.41±0.09和0.79±0.11。NCI-N87组的上述指标和实验组比较，oe-NC组的上述指标和LncRNA SNHG16组比较，在统计学上差异均有统计学意义（均P<0.001）。
结论 吡咯替尼可以通过抑制LncRNA SNHG16的表达调控p53/SLC7A11信号通路来诱导胃癌细胞铁死亡，从而抑制胃癌细胞的增殖和侵袭。
, authors=刘承一, 胡潺潺, 李青山, 肇爽, 陈慧, 李智慧, 焦海静, 殷亚兰, authorsList=刘承一, 胡潺潺, 李青山, 肇爽, 陈慧, 李智慧, 焦海静, 殷亚兰, authorCompany=null, correspAuthors=胡潺潺, authorNote=
刘承一（1975-），男，主治医师，主要从事肺癌、乳腺癌方面的临床诊疗工作
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