Article(id=1291404806015414284, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735056000000, receivedDateStr=2024-12-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824498895, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824498895, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824498895, creator=13701087609, updateTime=1785824498895, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1538, endPage=1543, ext={EN=ArticleExt(id=1291404806195769357, articleId=1291404806015414284, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Jinfu’an decoction-mediates autophagy on apoptosis in non-small cell lung cancer cells by regulating PI3K/Akt/mTOR signaling pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of Jinfu’an decoction on the apoptosis of non-small cell lung cancer cells (A549) by regulating phosphatidylinositol 3-kinase/ protein kinase B/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway mediated autophagy.
Methods A549 cells were randomly divided into blank group, control group, combined group and experimental -L, -M, -H groups. The blank group was treated with 10% blank serum. The control group was treated with 20 μmol·L-1 PI3K specific activator (740Y-P). The experimental-L, -M, -H groups were treated with 5%, 10% and 20% Jinfu ’an decoction containing serum, respectively. The combined group was treated with 20% Jinfu ’an decoction serum +20 μmol·L-1 740Y-P. Flow cytometry was used to detect the apoptosis rate. Western blot was used to detect the expression levels of microtubule-associated protein 1A/1B -light chain 3 (LC3), sequestosome-1 (p62), Akt and mTOR.
Results The apoptosis rates of experimental -H group, combined group, control group and blank group were (31.48±1.35)%, (14.91±1.26)%, (3.30±0.45)% and (7.73±0.50)%, respectively; the relative expression levels of LC3 Ⅱ/Ⅰ protein were 1.13±0.10, 0.77±0.06, 0.31±0.04 and 0.50±0.04, respectively; the relative expression levels of p62 protein were 0.32±0.03, 0.56±0.05, 1.07±0.06 and 0.83±0.06, respectively; the relative expression levels of p-Akt/Akt protein were 0.33±0.04, 0.80±0.07, 0.98±0.09 and 0.52±0.03, respectively; the relative expression levels of p-mTOR/mTOR protein were 0.53±0.04, 0.84±0.06, 1.14±0.08 and 1.01±0.06, respectively. The above indexes of the experimental -H group were statistically different from those of the combination group and the blank group (all P<0.05).
Conclusion Jinfu’an decoction can promote the apoptosis of A549 cells, and its mechanism may be related to the inhibition of PI3K/Akt/mTOR signaling pathway and the activation of cell autophagy.
, authors=Ming-yuan XING
1a, Xue-wu CHEN
1a, Ting WU
1a, Xue-ying LIN
1a, Ming-quan FU
1a, Kai-yu WANG
1b, authorsList=Ming-yuan XING, Xue-wu CHEN, Ting WU, Xue-ying LIN, Ming-quan FU, Kai-yu WANG, authorCompany=null, correspAuthors=Ming-yuan XING, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404806476787726, articleId=1291404806015414284, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=金福安汤调控PI3K/Akt/mTOR信号通路介导自噬对非小细胞肺癌细胞凋亡的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨金福安汤通过调控磷脂酰肌醇3-激酶/蛋白激酶B/西罗莫司靶蛋白（PI3K/Akt/mTOR）信号通路介导自噬对非小细胞肺癌细胞（A549）凋亡的影响。
方法 将A549细胞随机分为空白组、对照组、联合组和低、中、高剂量实验组。空白组给予10%空白血清处置；对照组给予20 μmol·L-1 PI3K特异性激活剂（740Y-P）处置；低、中、高剂量实验组分别给予5%、10%和20%金福安汤含药血清处置；联合组给予20%金福安汤含药血清+20 μmol·L-1 740Y-P处置。用流式细胞术检测细胞凋亡率，用蛋白质印迹法检测微管相关蛋白1A/1B-轻链3（LC3）、泛素结合蛋白（p62）、Akt和mTOR的表达水平。
结果 高剂量实验组、联合组、对照组和空白组的细胞凋亡率分别为（31.48±1.35）%、（14.91±1.26）%、（3.30±0.45）%和（7.73±0.50）%，LC3 Ⅱ/Ⅰ蛋白相对表达水平分别为1.13±0.10、0.77±0.06、0.31±0.04和0.50±0.04，p62蛋白相对表达水平分别为0.32±0.03、0.56±0.05、1.07±0.06和0.83±0.06，p-Akt/Akt蛋白相对表达水平分别为0.33±0.04、0.80±0.07、0.98±0.09和0.52±0.03，p-mTOR/mTOR蛋白相对表达水平分别为0.53±0.04、0.84±0.06、1.14±0.08和1.01±0.06。高剂量实验组的上述指标与联合组和空白组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 金福安汤可以促进A549细胞凋亡，其作用机制可能与抑制PI3K/Akt/mTOR信号通路进而激活细胞自噬有关。
, authors=邢明远
1a, 陈学武
1a, 吴亭
1a, 林学英
1a, 符茗铨
1a, 王开裕
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邢明远（1983-），男，副主任医师，主要从事恶性肿瘤的相关研究
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1b.Department of Pharmacy, Guangdong Provincial Traditional Chinese Medicine Hospital Hainan Hospital, Haikou 570203, Hainan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404809790287922, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404806015414284, authorId=1291404809630904367, language=CN, stringName=王开裕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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