Article(id=1291404802823545579, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404791758975909, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.11.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1735056000000, receivedDateStr=2024-12-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824498134, onlineDateStr=2026-08-04, pubDate=1750089600000, pubDateStr=2025-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824498134, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824498134, creator=13701087609, updateTime=1785824498134, updator=13701087609, issue=Issue{id=1291404791758975909, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1750089600000', pubDateStr='2025-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824495496, creator='13701087609', updateTime=1785824495496, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1641, endPage=1645, ext={EN=ArticleExt(id=1291404803054232300, articleId=1291404802823545579, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Correlation of G protein-coupled estrogen receptor and the metabolic syndrome, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

G protein-coupled estrogen receptor (GPER) is expressed in a variety of tissues and cells, mainly in the inner cell membrane (endoplasmic reticulum and Golgi apparatus), and also localized in the nucleus. Studies have shown that the GPER signaling pathway is involved in regulating the development of metabolic syndrome (MS), and the lack of GPER expression significantly induces MS features such as obesity, disorders of glucose-lipid metabolism, and hypertension in mice, whereas GPER agonists can improve glucose-lipid metabolism. In this paper, the correlation between GPER and various features of MS is reviewed, with the aim to providing research ideas for the development of anti-MS drugs based on GPER.

, authors=Yu-ting MA¹, Sheng-yu WEN¹, Zhu-fang SHEN^{1, 2}, Shuai-nan LIU^{1, 2}, Cai-na LI^{1, 2}, authorsList=Yu-ting MA, Sheng-yu WEN, Zhu-fang SHEN, Shuai-nan LIU, Cai-na LI, authorCompany=null, correspAuthors=Cai-na LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404803406553837, articleId=1291404802823545579, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=G蛋白偶联雌激素受体与代谢综合征的相关性研究, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

G蛋白偶联雌激素受体（GPER）在多种组织和细胞中均有表达，主要分布于细胞内膜（内质网和高尔基体），也可定位于细胞核。研究表明，GPER信号通路参与调节代谢综合征（MS）的发生发展，GPER表达缺失明显诱导小鼠出现肥胖、糖脂代谢紊乱、高血压等MS特征，而GPER激动药则可改善糖脂代谢。本文对GPER与MS各特征的相关性进行综述，以期为基于GPER研发抗MS药物提供研究思路。

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马玉婷（2001-），女，硕士研究生，主要从事糖脂代谢紊乱发生机制及相关治疗药物方面的研究

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马玉婷（2001-），女，硕士研究生，主要从事糖脂代谢紊乱发生机制及相关治疗药物方面的研究

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