Article(id=1291404745051206521, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730217600000, receivedDateStr=2024-10-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824484359, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824484359, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824484359, creator=13701087609, updateTime=1785824484359, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=937, endPage=942, ext={EN=ArticleExt(id=1291404746703762298, articleId=1291404745051206521, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of cardamonin on aerobic glycolysis and epithelial-mesenchymal transition in breast cancer cells MCF-7, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the regulation by cardamonin through targeting family 110 member A (FAM110A) regulate Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway on human breast cancer cells MCF-7 and effects of aerobic glycolysis and epithelial-mesenchymal transformation.
Methods The breast cancer cells MCF-7 were divided into control group (cultured normally), experimental group (cells treated with 20 μmol·L-1 cardamonin), oe-NC group (transfected with negative control plasmid oe-NC on the basis of experimental group), oe-FAM110A group (transfected with overexpressed plasmid oe-FAM110A on the basis of experimental group). Quantitative real-time polymerase chain reaction was used to detect the relative expression levels of FAM110A messenger RNA (mRNA) in each group of cells. The relative expression levels of FAM110A protein and the expression of E-cadherin and N-cadherin, which are related to epithelial mesenchymal transformation, were detected by immunofluorescence assay. Detection indexes of aerobic glycolysis in each group were detected by kit. The JAK2/STAT3 signaling pathway related protein phosphorylation level in each group was detected by Western blot.
Results The relative expression levels of FAM110A mRNA in control group and experimental group were 1.00±0.12 and 0.54±0.10, respectively, and the relative expression levels of FAM110A protein were 1.00±0.15 and 0.13±0.03, respectively; the mRNA and protein relative expression levels of FAM110A in experimental group were significantly different from those in control group (all P<0.05). The relative expression levels of E-cadherin protein in control group, experimental group, oe-NC group and oe-FAM110A group were 1.00±0.14, 2.98±0.51, 3.00±0.54 and 1.47±0.26, respectively; the relative expression levels of N-cadherin protein were 1.00±0.11, 0.41±0.08, 0.47±0.10 and 0.94±0.17; the relative lactic acid production were 1.00±0.19, 0.61±0.11, 0.59±0.09 and 0.98±0.16, respectively; the relative glucose absorption values were 1.00±0.16, 0.41±0.08, 0.42±0.08 and 0.88±0.15, respectively; the relative adenosine triphosphate production were 1.00±0.20, 0.29±0.05, 0.33±0.06 and 0.96±0.18, respectively; the phospho-JAK2/JAK2 levels were 1.00±0.17, 0.54±0.11, 0.58±0.10 and 0.91±0.15, respectively; the phospho-STAT3/STAT3 levels were 1.00±0.14, 0.37±0.06, 0.38±0.06 and 0.92±0.12, respectively; the above indexes in the experimental group were significantly different from those in the control group, and those in the oe-FAM110A group were significantly different from those in the oe-NC group (all P<0.05).
Conclusion Cardamonin can inhibit aerobic glycolysis and epithelial-mesenchymal transition in breast cancer cells MCF-7, and the mechanism may be through down-regulating FAM110A and inhibiting JAK2/STAT3 signaling pathway.
, authors=Ye ZHAO
1, 2, Gang PAN
1, 3, authorsList=Ye ZHAO, Gang PAN, authorCompany=null, correspAuthors=Gang PAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404746951226235, articleId=1291404745051206521, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=豆蔻明对乳腺癌细胞MCF-7有氧糖酵解和上皮间质转化的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究豆蔻明通过靶向序列相似性家族110成员A（FAM110A）调控Janus激酶2（JAK2）/信号转导和转录激活因子3（STAT3）信号通路对人乳腺癌细胞MCF-7有氧糖酵解和上皮间质转化的影响。
方法 将乳腺癌细胞MCF-7分为对照组（正常培养不做任何处理）、实验组（20 μmol·L-1豆蔻明处理）、oe-NC组（实验组基础上转染阴性对照质粒oe-NC）、oe-FAM110A组（实验组基础上转染过表达质粒oe-FAM110A）。用实时荧光定量聚合酶链反应实验检测各组细胞中FAM110A mRNA相对表达水平，用免疫荧光实验检测细胞中FAM110A蛋白、上皮间质转化相关蛋白E-cadherin和N-cadherin表达，用试剂盒检测各组细胞有氧糖酵解检测指标，用蛋白质印迹法检测各组细胞中JAK2/STAT3信号通路相关蛋白的磷酸化水平。
结果 对照组和实验组的FAM110A mRNA相对表达水平分别为1.00±0.12和0.54±0.10，FAM110A蛋白相对表达水平分别为1.00±0.15和0.13±0.03，在统计学上差异均有统计学意义（均P<0.05）。对照组、实验组、oe-NC组和oe-FAM110A组的E-cadherin蛋白相对表达水平分别为1.00±0.14、2.98±0.51、3.00±0.54和1.47±0.26，N-cadherin蛋白相对表达水平分别为1.00±0.11、0.41±0.08、0.47±0.10和0.94±0.17，相对乳酸生成量分别为1.00±0.19、0.61±0.11、0.59±0.09和0.98±0.16，相对葡萄糖吸收值分别为1.00±0.16、0.41±0.08、0.42±0.08和0.88±0.15，相对腺苷三磷酸生成量分别为1.00±0.20、0.29±0.05、0.33±0.06和0.96±0.18，磷酸化JAK2/JAK2水平分别为1.00±0.17、0.54±0.11、0.58±0.10和0.91±0.15，磷酸化STAT3/STAT3水平分别为1.00±0.14、0.37±0.06、0.38±0.06和0.92±0.12，实验组的上述指标与对照组相比，oe-FAM110A组的上述指标与oe-NC组相比，在统计学上差异均有统计学意义（均P<0.05）。
结论 豆蔻明可以抑制乳腺癌细胞MCF-7的有氧糖酵解和上皮间质转化进程，其机制可能是通过下调FAM110A表达来抑制JAK2/STAT3信号通路。
, authors=赵烨
1, 2, 潘钢
1, 3, authorsList=赵烨, 潘钢, authorCompany=null, correspAuthors=潘钢, authorNote=
赵烨（1998-），女，硕士研究生，主要从事肿瘤方面的相关研究
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1.浙江中医药大学 研究生院，浙江 杭州 310053
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1.School of Graduate, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
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1.浙江中医药大学 研究生院，浙江 杭州 310053
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