Article(id=1291404738566812464, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730131200000, receivedDateStr=2024-10-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824482813, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824482813, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824482813, creator=13701087609, updateTime=1785824482813, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1032, endPage=1037, ext={EN=ArticleExt(id=1291404738763944753, articleId=1291404738566812464, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the effect of adipokines on diabetic cardiomyopathy, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Obesity is a ‘key’ component that contributes to the further development of type 2 diabetes mellitus (T2DM). Adipose tissue releases adipokines that act on the cardiovascular system in an endocrine and paracrine manner, different adipokines have different effects. Pro-inflammatory adipokines exacerbate inflammatory responses and oxidative stress in cardiomyocytes, leading to myocardial hypertrophy and interstitial fibrosis, inducing heart failure. Anti-inflammatory adipokines protect against high glucose-induced vascular endothelial dysfunction and delay the development of cardiovascular complications in T2DM by inhibiting endoplasmic reticulum stress, oxidative stress and increasing nitric oxide production. Balancing the roles played by pro-inflammatory and anti-inflammatory adipokines in diabetic cardiomyopathy (DCM) is crucial. In this paper, we will study the effect of obesity-associated adipokines in DCM, summarise novel glucose-lowering drugs in the clinic that can both reduce body weight and benefit the heart, and provide a theoretical basis for preventing and treating the development of obesity-combined DCM.

, authors=Zhen-ya WU¹, Yi-fan WANG¹, Hong-mei MA¹, Sheng-nan LIU¹, Li-juan WANG¹, Fei-ru WANG³, Zi-qiong WANG¹, Hui-hui TANG¹, Wen YANG¹, Jin-yang WANG², authorsList=Zhen-ya WU, Yi-fan WANG, Hong-mei MA, Sheng-nan LIU, Li-juan WANG, Fei-ru WANG, Zi-qiong WANG, Hui-hui TANG, Wen YANG, Jin-yang WANG, authorCompany=null, correspAuthors=Jin-yang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404739053351730, articleId=1291404738566812464, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=脂肪因子对糖尿病心肌病影响的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

肥胖是促使2型糖尿病（T2DM）进一步发展的“关键”一环。脂肪组织释放脂肪因子，以内分泌及旁分泌的方式对心血管系统发挥作用，不同的脂肪因子有不同的影响效应。促炎脂肪因子加重心肌细胞的炎症反应和氧化应激，导致心肌肥大和间质纤维化，诱发心力衰竭。抗炎脂肪因子通过抑制内质网应激、氧化应激、增加一氧化氮的产生来保护高糖诱导的血管内皮功能障碍，延缓T2DM心血管并发症的发生。平衡促炎脂肪因子和抗炎脂肪因子在糖尿病心肌病（DCM）中所发挥的作用至关重要。本文将通过肥胖相关脂肪因子对DCM中的影响研究，总结临床中既能降低体质量，又可使心脏获益的新型降糖药物，为防治肥胖合并DCM的发生发展提供理论依据。

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武振亚（1997-），女，硕士研究生，主要从事内分泌代谢方向的相关研究

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武振亚（1997-），女，硕士研究生，主要从事内分泌代谢方向的相关研究

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