Article(id=1291404706618798697, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729008000000, receivedDateStr=2024-10-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824475197, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824475197, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824475197, creator=13701087609, updateTime=1785824475197, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=967, endPage=971, ext={EN=ArticleExt(id=1291404706794959466, articleId=1291404706618798697, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Banxia-Huanglian ameliorating diabetic gastroparesis rats based on the Akt/GSK-3 signaling pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the mechanism of Banxia-Huanglian (BX-HL) in improving diabetic gastroparesis based on dopaminergic synaptic pathway.
Methods The possible signaling pathways of BX-HL on the treatment of diabetic gastroparesis (DGP) were carried out by network pharmacology methods. The DGP model was constructed by intraperitoneal injection of 60 mg·kg-1 streptozotocin (STZ) + high-sugar and high-fat diet. The DGP rats were randomly divided into model group and experimental group, with 10 rats in each group; another 10 normal rats were taken as the normal group. The experimental group was administered by gavage with BX-HL solution at a dose of 1.35 g·kg·d-1, while the normal group and model group were administered by gavage with an equal volume of 0.9% NaCl once a day. The rats in the three groups were administered once a day for 21 days. The gastric emptying rate and intestinal propulsion rate of rats were measured by activated charcoal administration, the levels of neurotransmitter dopamine (DA) in brain tissues were determined by enzyme-linked immunosorbent assay, and the expression levels of protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) proteins in brain tissues were determined by Western blotting.
Results The effective components and corresponding signaling pathways, such as dopaminergic synapses, were screened by various databases for BX-HL on the treatment of diabetic gastroparesis. The fasting blood glucose levels in the normal group, model group and experimental group were (5.61±0.36), (23.40±1.58) and (6.18±0.42) mmol·L-1; the gastric emptying rates were (71.33±1.23)%, (35.43±3.12)% and (61.59±4.66)%; the intestinal transit rates were (53.19±3.48)%, (29.33±1.91)% and (38.53±2.80)%; the DA contents in brain tissue were (42.43±2.97), (88.20±8.46) and (52.64±5.03) pmol·L-1; the relative protein expression levels of Akt were 0.67±0.00, 1.35±0.04 and 0.94±0.01; the relative protein expression levels of GSK-3 were 0.96±0.01, 1.24±0.05 and 0.91±0.01, respectively. The above indexes of the experimental group showed statistical significance compared to the model group (all P<0.001).
Conclusion BX-HL has an ameliorative effect on diabetic gastroparesis in rats, which is mainly reflected in the lowering of blood glucose, the promotion of gastric emptying and intestinal propulsion, the reduction of neurotransmitter DA level, its mechanism may be related to inhibite the Akt/GSK-3 protein expression of dopaminergic synaptic pathway.
, authors=Qiong CHEN
1, 2, Jia-yi HUANG
1, 2, Xian-min SHEN
1, 2, Lu-rong ZHANG
1, 2, Fei WANG
1, 2, Heng XU
1, 2, authorsList=Qiong CHEN, Jia-yi HUANG, Xian-min SHEN, Lu-rong ZHANG, Fei WANG, Heng XU, authorCompany=null, correspAuthors=Fei WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404707075977835, articleId=1291404706618798697, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于Akt/GSK-3信号通路探讨半夏-黄连改善糖尿病胃轻瘫大鼠的作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 基于多巴胺能突触通路探讨半夏-黄连改善糖尿病胃轻瘫（DGP）的作用机制。
方法 用网络药理学方法对半夏-黄连治疗糖尿病胃轻瘫的信号通路进行分析。用腹腔注射60 mg·kg-1链脲佐菌素+高糖高脂饲料饲养构建DGP模型。将造模成功的DGP大鼠随机分为模型组和实验组，每组10只；另取10只正常大鼠作为正常组。实验组灌胃给予1.35 g·kg-1·d-1的半夏-黄连溶液，正常组和模型组均灌胃给予等体积0.9% NaCl。3组大鼠每天给药１次，连续给药21 d。用灌服活性炭的方法测量大鼠的胃排空率和肠推进率，用酶联免疫吸附试验法测定脑组织中神经递质多巴胺（DA）的水平，用蛋白质印迹法测定脑组织中蛋白激酶B（Akt）和糖原合成酶激酶-3（GSK-3）蛋白的表达水平。
结果 通过多种数据库共筛选得到半夏-黄连治疗糖尿病胃轻瘫主要通过多巴胺能突触等多条信号通路。正常组、模型组和实验组的空腹血糖水平分别为（5.61±0.36）、（23.40±1.58）和（6.18±0.42）mmol·L-1，胃排空率分别为（71.33±1.23）%、（35.43±3.12）%和（61.59±4.66）%，肠推进率分别为（53.19±3.48）%、（29.33±1.91）%和（38.53±2.80）%，脑组织匀浆液中DA含量分别为（42.43±2.97）、（88.20±8.46）和（52.64±5.03）pmol·L-1，Akt蛋白相对表达水平分别为0.67±0.00、1.35±0.04和0.94±0.01，GSK-3蛋白相对表达水平分别为0.96±0.01、1.24±0.05和0.91±0.01。实验组的上述指标与模型组相比，在统计学上差异均有统计学意义（均P<0.001）。
结论 半夏-黄连对糖尿病胃轻瘫大鼠具有改善作用，其主要体现在降低空腹血糖、促进胃排空和肠推进，降低脑组织DA水平，其作用机制可能是通过抑制多巴胺能突触通路Akt/GSK-3蛋白表达来发挥作用。
, authors=陈琼
1, 2, 黄佳怡
1, 2, 沈贤敏
1, 2, 张露蓉
1, 2, 王斐
1, 2, 许恒
1, 2, authorsList=陈琼, 黄佳怡, 沈贤敏, 张露蓉, 王斐, 许恒, authorCompany=null, correspAuthors=王斐, authorNote=
陈琼（2001-），女，硕士研究生，主要从事中药防治糖尿病及其并发症的机制研究
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1.南京中医药大学 附属苏州市中医医院 中心实验室，江苏 苏州 215009
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1.Central Laboratory, Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, Jiangsu Province, China
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1.南京中医药大学 附属苏州市中医医院 中心实验室，江苏 苏州 215009
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1.Central Laboratory, Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, Jiangsu Province, China
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1.Central Laboratory, Suzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, Jiangsu Province, China
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