Article(id=1291404689698976302, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728489600000, receivedDateStr=2024-10-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824471162, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824471162, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824471162, creator=13701087609, updateTime=1785824471162, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=949, endPage=954, ext={EN=ArticleExt(id=1291404690160349743, articleId=1291404689698976302, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of silica nanoparticles on platelets and coagulation system, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To study the effects and safety of silica nanoparticles (SiNPs) on platelets and coagulation system, and initially to explore the mechanism related to the procoagulation of SiNPs.
Methods Blood from the abdominal aorta of rats was taken for in vitro experiments to evaluate the blood safety of 10, 50, 100, 200 μg·mL-1 of SiNPs. Hematological toxicity was studied using hemolysis assay and lactate dehydrogenase assay. Platelet aggregation was detected by light transmission aggregometry. Platelet activation was detected by platelet surface activation receptor P-selectin. The effects of SiNPs on coagulation were also determined by activated partial tromboplastin time (APTT), thrombin time (TT), prothrombin time (PT) and fibrinogen (Fib).
Results In platelet-related studies, the max platelet aggregation was (49.38±13.66)% with SiNPs concentration of 200 μg·mL-1 and platelet activation occurred with 50 μg·mL-1 SiNPs exposing P-selectin. In coagulation sudies, the PT in 0.9% NaCl and 100 μg·mL-1 of SiNPs were (9.04±0.20) and (8.36±0.32) s, the blood coagulation indexes were (100.00±0.00)% and (90.06±7.81)%, and the differences were statistically significant (all P<0.05).
Conclusion High concentrations of SiNPs can cause platelet aggregation and activation, shorten PT and promote blood coagulation.
, authors=Ying-xin ZHAO
1, 2, Jiu-long LI
3, Zhe WANG
2, Huan MENG
3, Yi-min CUI
1, 2, Qian XIANG
1, 2, authorsList=Ying-xin ZHAO, Jiu-long LI, Zhe WANG, Huan MENG, Yi-min CUI, Qian XIANG, authorCompany=null, correspAuthors=Qian XIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404692228141619, articleId=1291404689698976302, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=二氧化硅纳米粒对血小板及凝血系统的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究二氧化硅纳米粒（SiNPs）对血小板及凝血系统的影响及安全性，探索SiNPs促凝相关的机制。
方法 取大鼠腹主动脉血进行体外实验，对不同质量浓度（10、50、100、200 μg·mL-1）SiNPs进行血液安全性评估。用溶血实验和乳酸脱氢酶实验研究其血液学毒性。用光比浊法检测血小板聚集，通过血小板表面活化受体P-选择素检测血小板活化，同时通过活化部分凝血活酶时间、凝血酶时间、凝血酶原时间和纤维蛋白原判断SiNPs对凝血功能的影响。
结果 在血小板相关的研究中，SiNPs质量浓度为200 μg·mL-1时，血小板的最大聚集率为（49.38±13.66）%，且50 μg·mL-1的SiNPs能使P-选择素暴露，血小板发生活化。在凝血研究中，0.9% NaCl和100 μg·mL-1 SiNPs组的凝血酶原时间分别为（9.04±0.20）和（8.36±0.32）s，凝血指数分别为（100.00±0.00）%和（90.06±7.81）%，在统计学上差异均有统计学意义（均P<0.05）。
结论 高质量浓度的SiNPs可以使血小板聚集和活化，缩短凝血酶原时间，促进凝血。
, authors=赵颖昕
1, 2, 李九龙
3, 王哲
2, 孟幻
3, 崔一民
1, 2, 向倩
1, 2, authorsList=赵颖昕, 李九龙, 王哲, 孟幻, 崔一民, 向倩, authorCompany=null, correspAuthors=向倩, authorNote=
赵颖昕（1998-），女，硕士研究生，主要从事纳米材料安全性评价方面的相关研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=5v1/D10S4+s8gvGX3+qpKw==, magXml=K3sMcyO9cWoDrDe1xrY8ow==, pdfUrl=null, pdf=bJr8523sUuPbPlRB/AwZIg==, pdfFileSize=1614473, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=0iQMFcRVxZuPrHQGZeD+MQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291404694916690495, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404695197708866, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404694916690495, language=EN, stringName=Ying-xin ZHAO, firstName=Ying-xin, middleName=null, lastName=ZHAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404695508087363, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404694916690495, language=CN, stringName=赵颖昕, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.温州医科大学 药学院，浙江 温州 325035
2.北京大学 第一医院 临床药理研究所，北京 100191, bio={"content":"
赵颖昕（1998-），女，硕士研究生，主要从事纳米材料安全性评价方面的相关研究
"}, bioImg=null, bioContent=
赵颖昕（1998-），女，硕士研究生，主要从事纳米材料安全性评价方面的相关研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693880697397, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=1., ext=[AuthorCompanyExt(id=1291404693914251830, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China), AuthorCompanyExt(id=1291404694241407543, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.温州医科大学 药学院，浙江 温州 325035)]), AuthorCompany(id=1291404694350459448, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=2., ext=[AuthorCompanyExt(id=1291404694669226553, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China), AuthorCompanyExt(id=1291404694686003770, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.北京大学 第一医院 临床药理研究所，北京 100191)])]), Author(id=1291404697223557701, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404697315832391, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404697223557701, language=EN, stringName=Jiu-long LI, firstName=Jiu-long, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.National Nanoscience Center, Chinese Academy of Sciences, Beijing 100190, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404697391329864, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404697223557701, language=CN, stringName=李九龙, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.中国科学院 国家纳米中心，北京 100190, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404694811832891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=3., ext=[AuthorCompanyExt(id=1291404694820221500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.National Nanoscience Center, Chinese Academy of Sciences, Beijing 100190, China), AuthorCompanyExt(id=1291404694828610109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.中国科学院 国家纳米中心，北京 100190)])]), Author(id=1291404697659765322, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404697747845708, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404697659765322, language=EN, stringName=Zhe WANG, firstName=Zhe, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404698100167245, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404697659765322, language=CN, stringName=王哲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2, address=
2.北京大学 第一医院 临床药理研究所，北京 100191, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404694350459448, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=2., ext=[AuthorCompanyExt(id=1291404694669226553, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China), AuthorCompanyExt(id=1291404694686003770, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.北京大学 第一医院 临床药理研究所，北京 100191)])]), Author(id=1291404698179859023, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404698251162193, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404698179859023, language=EN, stringName=Huan MENG, firstName=Huan, middleName=null, lastName=MENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.National Nanoscience Center, Chinese Academy of Sciences, Beijing 100190, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404698452488786, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404698179859023, language=CN, stringName=孟幻, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
3, address=
3.中国科学院 国家纳米中心，北京 100190, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404694811832891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=3., ext=[AuthorCompanyExt(id=1291404694820221500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.National Nanoscience Center, Chinese Academy of Sciences, Beijing 100190, China), AuthorCompanyExt(id=1291404694828610109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.中国科学院 国家纳米中心，北京 100190)])]), Author(id=1291404698511209044, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404698616066647, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404698511209044, language=EN, stringName=Yi-min CUI, firstName=Yi-min, middleName=null, lastName=CUI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404698922250840, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404698511209044, language=CN, stringName=崔一民, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.温州医科大学 药学院，浙江 温州 325035
2.北京大学 第一医院 临床药理研究所，北京 100191, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693880697397, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=1., ext=[AuthorCompanyExt(id=1291404693914251830, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China), AuthorCompanyExt(id=1291404694241407543, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.温州医科大学 药学院，浙江 温州 325035)]), AuthorCompany(id=1291404694350459448, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=2., ext=[AuthorCompanyExt(id=1291404694669226553, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China), AuthorCompanyExt(id=1291404694686003770, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.北京大学 第一医院 临床药理研究所，北京 100191)])]), Author(id=1291404699333292634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=xiangqz@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404699723362910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404699333292634, language=EN, stringName=Qian XIANG, firstName=Qian, middleName=null, lastName=XIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404700151181919, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, authorId=1291404699333292634, language=CN, stringName=向倩, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2, address=
1.温州医科大学 药学院，浙江 温州 325035
2.北京大学 第一医院 临床药理研究所，北京 100191, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693880697397, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=1., ext=[AuthorCompanyExt(id=1291404693914251830, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China), AuthorCompanyExt(id=1291404694241407543, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.温州医科大学 药学院，浙江 温州 325035)]), AuthorCompany(id=1291404694350459448, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=2., ext=[AuthorCompanyExt(id=1291404694669226553, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China), AuthorCompanyExt(id=1291404694686003770, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.北京大学 第一医院 临床药理研究所，北京 100191)])])], keywords=[Keyword(id=1291404701841486432, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=EN, orderNo=1, keyword=silica nanoparticle), Keyword(id=1291404703703757409, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=EN, orderNo=2, keyword=coagulation function), Keyword(id=1291404703909278306, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=EN, orderNo=3, keyword=platelet), Keyword(id=1291404703984775779, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=EN, orderNo=4, keyword=coagulation), Keyword(id=1291404704047690340, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=CN, orderNo=1, keyword=二氧化硅纳米粒), Keyword(id=1291404704139965029, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=CN, orderNo=2, keyword=凝血功能), Keyword(id=1291404704207073894, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=CN, orderNo=3, keyword=血小板), Keyword(id=1291404704332903015, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, language=CN, orderNo=4, keyword=凝血)], refs=null, funds=[Fund(id=1291404704454537832, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, awardId=2023IR06, language=CN, fundingSource=中央高水平医院临床科研业务基金资助(2023IR06), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291404693880697397, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=1., ext=[AuthorCompanyExt(id=1291404693914251830, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China), AuthorCompanyExt(id=1291404694241407543, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404693880697397, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1.温州医科大学 药学院，浙江 温州 325035)]), AuthorCompany(id=1291404694350459448, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=2., ext=[AuthorCompanyExt(id=1291404694669226553, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100191, China), AuthorCompanyExt(id=1291404694686003770, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694350459448, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
2.北京大学 第一医院 临床药理研究所，北京 100191)]), AuthorCompany(id=1291404694811832891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, xref=3., ext=[AuthorCompanyExt(id=1291404694820221500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.National Nanoscience Center, Chinese Academy of Sciences, Beijing 100190, China), AuthorCompanyExt(id=1291404694828610109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404689698976302, companyId=1291404694811832891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
3.中国科学院 国家纳米中心，北京 100190)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.07.010, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.07.010, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.07.010, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.07.010, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1744819200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
3
1
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
