Article(id=1291404684149907787, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729267200000, receivedDateStr=2024-10-19, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824469839, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824469839, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824469839, creator=13701087609, updateTime=1785824469839, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=911, endPage=915, ext={EN=ArticleExt(id=1291404684351234380, articleId=1291404684149907787, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of esketamine combined with sevoflurane in the treatment of pediatric patients undergoing laparoscopic surgery, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of different doses of esketamine injection combined with sevoflurane inhalation in the treatment of children undergoing laparoscopic surgery.
Methods The elective laparoscopic surgery children with general anesthesia were randomly divided into control group and treatment -L, -H groups. Three groups received anesthesia induction with 2%-3% sevoflurane + 2-3 μg·kg-1 fentanyl + 0.15 mg·kg-1 remimazolam. Five minutes before the start of the surgery, the treatment -L group was administered 0.25 mg·kg-1 esketamine + 2%-3% sevoflurane for anesthesia maintenance, the treatment -H group received 0.50 mg·kg-1 esketamine + 2%-3% sevoflurane for anesthesia maintenance, the control group was given an equal volume of 0.9% NaCl + 2%-3% sevofluran for anesthesia maintenance, sevoflurane inhalation was stopped 10 minutes before the end of the surgery. The pediatric anesthesia emergence delirium (PAED) score at the time of entering the post-anesthesia care unit (PACU), face, legs, activity, cry, consolability (FLACC) score at 6 h after surgery, wakefulness time and safety were compared among three groups.
Results Treatment -L group was enrolled 94 cases, 5 cases dropped out, and 89 cases were finally included in the statistical analysis; treatment -H group was enrolled 94 cases, 1 case dropped out, and 93 cases were finally included in the statistical analysis; control group was enrolled 88 cases, 2 cases dropped out, and 86 cases were finally included in the statistical analysis. The PAED scores at the time of entering the PACU in treatment -L, -H groups and control group were (9.15±1.30), (7.03±1.24) and (12.45±1.43) points; the FLACC scores at 6 h after surgery were (1.54±0.58), (1.22±0.51) and (2.26±0.64) points; the wakefulness time was (10.84±2.25), (15.92±2.62) and (10.56±2.19) min, respectively; the differences of above indexes were statistically significant between the treatment -L and control groups and the treatment -H group (all P<0.05). The adverse drug reactions of treatment -L and treatment-H groups were drowsiness and tachycardia, while those in the control group were experienced laryngospasm, respiratory depression and tachycardia. The incidences of total adverse drug reactions in treatment -L, treatment -H and control groups were 7.87%, 8.60% and 8.14%, respectively, without significant differences (all P>0.05).
Conclusion Esketamine injection combined with sevoflurane inhalation can help to maintain children’s hemodynamic stability undergoing laparoscopic surgery, the dose of 0.25 mg·kg-1·h-1 of esketamine can improve analgesia efficacy without prolonging the recovery time and increasing the incidence of adverse drug reactions.
, authors=Xue LI, Ping ZHANG, Jia-xu MA, authorsList=Xue LI, Ping ZHANG, Jia-xu MA, authorCompany=null, correspAuthors=Jia-xu MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404684917465421, articleId=1291404684149907787, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=艾司氯胺酮联合七氟烷用于腹腔镜手术患儿的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察不同剂量艾司氯胺酮注射液联合吸入用七氟烷用于腹腔镜手术患儿中的临床疗效及安全性。
方法 将择期行全身麻醉下腹腔镜手术患儿随机分为对照组和低、高剂量试验组。3组患儿均给予2%~3%七氟烷+2~3 μg·kg-1芬太尼+瑞马唑仑0.15 mg·kg-1进行麻醉诱导。手术开始前5 min，低剂量试验组给予0.25 mg·kg-1艾司氯胺酮+2%~3%七氟烷进行麻醉维持，高剂量试验组给予0.50 mg·kg-1艾司氯胺酮+2%~3%七氟烷进行麻醉维持，对照组给予等体积0.9% NaCl+2%~3%七氟烷进行麻醉维持，于手术结束前10 min停止吸入七氟烷。比较3组患儿入麻醉恢复室（PACU）即刻的苏醒期躁动（PAED）评分、术后6 h的疼痛行为（FLACC）评分和苏醒时间，以及安全性。
结果 低剂量试验组入组94例，脱落5例，最终有89例纳入统计分析；高剂量试验组入组94例，脱落1例，最终有93例纳入统计分析；对照组入组88例，脱落2例，最终有86例纳入统计分析。低、高剂量试验组和对照组的入PACU即刻的PAED评分分别为（9.15±1.30）、（7.03±1.24）和（12.45±1.43）分，术后6 h的FLACC评分分别为（1.54±0.58）、（1.22±0.51）和（2.26±0.64）分，苏醒时间分别为（10.84±2.25）、（15.92±2.62）和（10.56±2.19）min，高剂量试验组的上述指标与对照组和低剂量试验组比较，在统计学上差异均有统计学意义（均P<0.05）。低、高剂量试验组的药物不良反应主要有嗜睡和心动过速，对照组的药物不良反应主要有喉痉挛、呼吸抑制和心动过速。低、高剂量试验组和对照组的总药物不良反应发生率分别为7.87%、8.60%和8.14%，组间两两比较，在统计学上差异均无统计学意义（均P>0.05）。
结论 艾司氯胺酮注射液联合吸入用七氟烷有助于维持腹腔镜手术患儿术中血流动力学稳定，且0.25 mg·kg-1·h-1艾司氯胺酮在提高镇痛效果的同时不会延长苏醒时间，也不会增加药物不良反应的发生率。
, authors=李雪, 张平, 马加旭, authorsList=李雪, 张平, 马加旭, authorCompany=null, correspAuthors=马加旭, authorNote=
李雪（1989-），女，主治医师，主要从事临床麻醉的相关工作
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李雪（1989-），女，主治医师，主要从事临床麻醉的相关工作
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