Article(id=1291404600452575498, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728576000000, receivedDateStr=2024-10-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824449884, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824449884, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824449884, creator=13701087609, updateTime=1785824449884, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=881, endPage=885, ext={EN=ArticleExt(id=1291404600884588811, articleId=1291404600452575498, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of the clinical prescription of semaglutide, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate prescription of semaglutide and analyzed status of semaglutide administration in China’s real-world.
Methods The prescription including semaglutide were extracted from 9 cities across China in first quarter of 2023. We analyzed the current administration of semaglutide and risk factors of off-label use of semaglutide by multivariant logistic regression.
Results A total of 10 884 patients were included after data screening, about 70% patients were 34-64 years old. Endocrinology was the most common prescription department. Diabetes was diagnosed in 76.78% patients and 765 patients combined chronic complications of diabetes, of which diabetic neuropathy (470 cases, 4.32%) and diabetic nephropathy (248 cases, 2.28%) were the most common complications. Cardiovascular diseases and risk factors were diagnosed in 2 429 patients. Hypertension (1 379 cases, 12.67%) and hyperlipemia (1 342 cases, 11.31%) were the most common cardiovascular disease and risk factors. While 56.74% (6 176 cases) patients were treated by semaglutide singe-agent in general, 36.79% (3 075 cases/ 8 357 cases) patients with diabetes combined oral hypoglycemic drugs or insulin, and biguanides and sodium-dependent glucose transporters 2 inhibitors were used mostly. About 1/4 patients without diabetes off-label administrated semaglutide. According to the logistic regression, risk factors of off-label use were elder age, came from first-tier cities, prescription from endocrinology and a greater number of combined cardiovascular diseases and risk factors.
Conclusion Semaglutide -based therapy regimens in patients with diabetes are fairly standardized according to clinical guidelines, while off-label use in patients without diabetes are supported by clinical evidence and guidelines to some extent.
, authors=Bin ZHANG, Ke-lu HOU, Yue CHEN, Hai-ying ZHANG, authorsList=Bin ZHANG, Ke-lu HOU, Yue CHEN, Hai-ying ZHANG, authorCompany=null, correspAuthors=Hai-ying ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404602050605324, articleId=1291404600452575498, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=司美格鲁肽临床使用的情况分析, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 研究我国真实世界中司美格鲁肽处方的使用情况，并分析其给药现状。
方法 抽取全国9个城市2023年第一季度使用司美格鲁肽的处方数据，分析司美格鲁肽的患者及使用情况，并用多元Logistics回归方法分析司美格鲁肽超说明书用药的风险因素。
结果 经过数据初筛，最终纳入10 884例患者进行数据分析，约70%患者集中在34~64岁年龄段，主要处方科室是内分泌科。76.78%的患者有糖尿病诊断。765例存在各种糖尿病慢性并发症，以糖尿病神经病变（470例，4.32%）和糖尿病肾病（248例，2.28%）最多；2 429例患者合并诊断心血管疾病和危险因素，以高血压（1 379例，12.67%）和高脂血症（1 342例，11.31%）最常见。56.74%（6 176例）的患者为司美格鲁肽单药治疗，36.79%（3 075例/8 357例）糖尿病患者合并使用口服降糖药或胰岛素，以双胍类和钠-葡萄糖协同转运蛋白2抑制药最多。约1/4的非糖尿病患者超说明书使用司美格鲁肽，风险因素分析显示，较高的年龄、所在地区一线城市、处方科室是内分泌科、较多的合并心血管疾病及危险因素的数量与司美格鲁肽超说明书用药的风险增加相关。
结论 糖尿病患者的含司美格鲁肽的治疗方案较为规范，基本符合临床指南推荐；超说明书用药的非糖尿病患者，在临床证据和指南共识的支持下，有一定的使用依据。
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张斌（1975-），女，主管药师，主要从事医院药学方向的相关研究
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