Article(id=1291404594001732556, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728921600000, receivedDateStr=2024-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824448346, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824448346, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824448346, creator=13701087609, updateTime=1785824448346, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=895, endPage=900, ext={EN=ArticleExt(id=1291404594735735757, articleId=1291404594001732556, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Development of non-clinical pharmacodynamic evaluation of IgA nephropathy, columnId=1291339025546211579, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Drug Evaluation and Administration, runingTitle=null, highlight=null, articleAbstract=

Immunoglobulin A (IgA) nephropathy is a common primary glomerular disease. Because the pathogenesis of IgA nephropathy is still unclear, it is difficult to study the pharmacodynamics of IgA nephropathy through an ideal non-clinical pharmacodynamic model. In order to provide non-clinical efficacy research and development reference for IgA nephropathy drugs, the non-clinical pharmacodynamic research and development of IgA nephropathy drugs, non-clinical efficacy model, clinical and non-clinical efficacy evaluation index of overseas marketed products in recent years are introduced in this paper.

, authors=Zeng-ping XU, Qing-li WANG, Mei-ling CHEN, Hong-mei GUANG, authorsList=Zeng-ping XU, Qing-li WANG, Mei-ling CHEN, Hong-mei GUANG, authorCompany=null, correspAuthors=Hong-mei GUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404595125806030, articleId=1291404594001732556, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=IgA肾病的非临床药效学评价进展, columnId=1291339025730760957, journalTitle=中国临床药理学杂志, columnName=药物评价与管理, runingTitle=null, highlight=null, articleAbstract=

免疫球蛋白A（IgA）肾病是常见的一种原发性肾小球疾病。由于IgA肾病的发病机制目前尚未明确，通过一种理想的非临床药效模型对IgA肾病进行药效学研究较为困难。本文通过介绍IgA肾病的非临床药效学研发进展，近年来国外已上市产品的非临床药效模型、临床和非临床有效性评价指标等信息，以期为IgA肾病药物的研发提供非临床药效研发参考。

, authors=许曾平, 王庆利, 陈美灵, 光红梅, authorsList=许曾平, 王庆利, 陈美灵, 光红梅, authorCompany=null, correspAuthors=光红梅, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=9NjqT4CDI4SUlC1bJgqKmA==, magXml=8E1vkMOQb+l3okuFqJWzjA==, pdfUrl=null, pdf=x95iGMC1IvCE6B0Ar+SNVA==, pdfFileSize=1359329, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=u5A5dP0yYGgIZYVxkCEQBQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291404663174193453, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404594001732556, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404663933362479, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404594001732556, authorId=1291404663174193453, language=EN, stringName=Zeng-ping XU, firstName=Zeng-ping, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Centre for Drug Evaluation, National Medical Products Administration, Beijing 100076, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404664000471344, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404594001732556, authorId=1291404663174193453, language=CN, stringName=许曾平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=国家药品监督管理局 药品审评中心，北京 100076, bio={"content":"

许曾平（1990-），男，主管药师，主要从事新药药理毒理审评工作

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许曾平（1990-），男，主管药师，主要从事新药药理毒理审评工作

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