Article(id=1291404565031669990, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732464000000, receivedDateStr=2024-11-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824441439, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824441439, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824441439, creator=13701087609, updateTime=1785824441439, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=751, endPage=754, ext={EN=ArticleExt(id=1291404565283328231, articleId=1291404565031669990, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical characteristics and drug resistance of strain analysis of patients with emphysematous pyelonephritis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the clinical characteristics of patients infected with emphysematous pyelonephritis (EPN) and the drug resistance of the strains. To enhance the understanding of EPN, provide a basis for the selection of antibacterial drugs in clinical practice.
Methods Evaluated 15 EPN patients’ clinical characteristics and outcome, analysis of pathogenic bacteria and drug resistance.
Results Among the 15 EPN patients, 66.67% (10 cases/15 cases) patients were cured, 13.33% (2 cases/15 cases) patients died, and 20.00% (3 cases/15 cases) patients were adverse. Fluid cultures identified 12 strains of pathogenic bacteria, with Escherichia coli being the most prevalent (66.67%, 8 cases/12 cases), followed by Klebsiella pneumoniae (25.00%, 3 cases/12 cases), and Pseudomonas aeruginosa was the least common (8.33%, 1 cases/12 cases), 75.00% (9 cases/12 cases) of the strains were multi-drug resistant. The drug sensitivity test results showed that amikacin, cefotetan, and cefoperazone sulbactam were 100.00% sensitive antibiotics; the sensitivity rates of meropenem, imipenem, and ertapenem were 91.67%.
Conclusion Patients with EPN have high mortality and poor prognosis. Escherichia coli was the most common pathogenic bacteria, followed by Klebsiella pneumoniae, and the proportion of multi-drug resistant strains was high. We recommend the use of over 90% of the pathogen-sensitive drugs with susceptibility about 90% identified in this study.
, authors=Cheng-cheng SUN
1a, Jia-en ZHANG
1b, Yi LIU
1c, Hui XIONG
1a, Yi-xiang MA
1a, authorsList=Cheng-cheng SUN, Jia-en ZHANG, Yi LIU, Hui XIONG, Yi-xiang MA, authorCompany=null, correspAuthors=Yi-xiang MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404566050885864, articleId=1291404565031669990, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=气肿性肾盂肾炎患者的临床特征及菌株耐药性分析, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 分析气肿性肾盂肾炎（EPN）患者的临床特征及菌株耐药性，提高对EPN的认识，为临床合理选择抗菌药物提供依据。
方法 分析15例EPN患者的临床特征、预后和病原菌分布及耐药性特点。
结果 在15例EPN患者中，66.67%（10例/15例）患者治愈，13.33%（2例/15例）患者死亡，20.00%（3例/15例）患者预后不佳。检出12例患者病原菌阳性，其中致病菌包括大肠埃希菌8例（66.7%）、肺炎克雷伯菌3例（25.00%）、铜绿假单胞菌1例（8.33%）；多重耐药菌株9例（75.00%）。药敏结果显示：本研究培养的细菌对阿米卡星、头孢替坦、头孢哌酮舒巴坦敏感率均为100.00%；美罗培南、亚胺培南、厄他培南敏感率均为91.67%。
结论 EPN患者死亡率高，预后差。大肠埃希菌是最常见的致病菌，其次为肺炎克雷伯菌，多重耐药菌株比例高，初始抗感染治疗推荐优先使用本研究敏感率90%以上的药物。
, authors=孙程程
1a, 张嘉恩
1b, 刘义
1c, 熊辉
1a, 马义祥
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