Article(id=1291404564066989040, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729612800000, receivedDateStr=2024-10-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824441209, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824441209, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824441209, creator=13701087609, updateTime=1785824441209, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=772, endPage=776, ext={EN=ArticleExt(id=1291404564255732721, articleId=1291404564066989040, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Arctigenin ameliorates bronchial epithelial cell injury in
Pseudomonas aeruginosa infection, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of arctigenin on bronchial epithelial cell injury caused by Pseudomonas aeruginosa (PA) infection and its mechanism.
Methods BEAS-2B cells were randomly divided into control group (conventional culture), PA group (1.50×108 CFU·mL-1 PA infection), PA+ low dose group (PA combined with 10.00 mmol·L-1 burdock aglycone), PA+ high-dose group (PA combined with 20.00 mmol·L-1 burdock aglycone). The expression of inflammatory factors and glutathione (GSH) was detected by kit assay, glutathione peroxidase 4 (GPX4) protein was detected by Western blot assay, and lipid peroxidation levels were detected by immunofluorescence assay.
Results The IL-6 contents of control group, PA group, PA+ low dose group and PA+ high dose group were (20.43±2.82), (106.28±8.07), (76.66±5.73) and (50.57±3.98) pg·mL-1, respectively; the GSH contents were (25.95±1.46), (10.59±0.60), (13.98±0.74) and (21.52±2.36) ng·mL-1, respectively; GPX4 protein expression levels were 0.76±0.06, 0.33±0.05, 0.46±0.05 and 0.62±0.06, respectively; the lipid peroxidation levels were (100.00±4.29)%, (470.91±36.33)%, (331.16±27.04)% and (160.16±18.65)%, respectively. The above indexes in PA group compared with control group, PA+ low dose group and PA+ high dose group were compared with PA group, and the differences were all statistically significant (all P<0.01).
Conclusion Arctigenin can reduce the inflammation of PA-infected BEAS-2B cells by inhibiting GPX4-related ferroptosis pathway.
, authors=Yan XU
1a, Kai WANG
1a, Ping SHEN
1b, authorsList=Yan XU, Kai WANG, Ping SHEN, authorCompany=null, correspAuthors=Ping SHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404564574499826, articleId=1291404564066989040, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=牛蒡子苷元对铜绿假单胞菌感染的支气管上皮细胞损伤的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨牛蒡子苷元对铜绿假单胞菌（PA）感染的支气管上皮细胞损伤的影响及其机制。
方法 将BEAS-2B细胞随机分为对照组（常规培养）、PA组（1.50×108CFU·mL-1的PA菌液感染）、PA+低剂量组（PA菌液联合10.00 mmol·L-1的牛蒡子苷元）、PA+高剂量组（PA菌液联合20.00 mmol·L-1的牛蒡子苷元）。用试剂盒法检测细胞炎性因子及谷胱甘肽（GSH）表达，用蛋白质印迹法检测谷胱甘肽过氧化物酶4（GPX4）蛋白表达情况，用免疫荧光法检测脂质过氧化水平。
结果 对照组、PA组、PA+低剂量组、PA+高剂量组的白细胞介素（IL）-6含量分别为（20.43±2.82）、（106.28±8.07）、（76.66±5.73）和（50.57±3.98）pg·mL-1，GSH含量分别为（25.95±1.46）、（10.59±0.60）、（13.98±0.74）和（21.52±2.36）ng·mL-1，GPX4蛋白相对表达水平分别为0.76±0.06、0.33±0.05、0.46±0.05和0.62±0.06，脂质过氧化水平分别为（100.00±4.29）%、（470.91±36.33）%、（331.16±27.04）%和（160.16±18.65）%；PA组的上述指标分别与对照组比较，在统计学上差异均有统计学意义（均P<0.01），PA+低剂量组、PA+高剂量组的上述指标分别与PA组比较，在统计学上差异均有统计学意义（均P<0.01）。
结论 牛蒡子苷元可以通过抑制GPX4相关铁死亡途径减轻PA感染的BEAS-2B细胞炎症反应。
, authors=徐燕
1a, 王凯
1a, 沈萍
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徐燕（1987-），女，副主任技师，主要从事临床微生物检验方面的研究
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