Article(id=1291404559520354504, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729785600000, receivedDateStr=2024-10-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824440126, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824440126, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824440125, creator=13701087609, updateTime=1785824440125, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=777, endPage=783, ext={EN=ArticleExt(id=1291404559738458313, articleId=1291404559520354504, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research on the anti-inflammatory effects and pyroptosis of nobiletin on lipopolysaccharide-induced periodontal ligament cells, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effect and mechanism of circular RNA RAS p21 protein activator 2 (circRASA2) mediated by nobiletin (NOB) on lipopolysaccharide (LPS)-induced hPDLCs in periodontal ligament cells.
Methods hPDLCs cells were divided into control group, model group (hPDLCs cells were treated with 10 μg·mL-1 LPS for 24 h), NOB-H group (Based on the model group, 20 μmol·L-1 NOB was given for 24 h), NOB+oe-NC group (hPDLCs cells transfected with oe-NC were treated with 20 μmol·L-1 NOB) and NOB+oe-circRASA2 group (hPDLCs cells transfected with oe-circRASA2 were treated with 20 μmol·L-1 NOB). Quantitative real time polymerase chain reaction was used to detect the mRNA expression levels of circRASA2. The secretion levels of inflammation-related factors were detected by enzyme-linked immunosorbent assay. Western blot analysis of slit homolog 2 (Slit2)/mitogen-activated protein kinase (MAPK) signaling pathway related protein expression levels.
Results The relative expression levels of circRASA2 in control group, model group and NOB-H group were 1.00±0.15, 2.83±0.50 and 1.36±0.27, respectively. The levels of interleukin-1β in control group, model group, NOB-H group, NOB+oe-NC group and NOB+oe-circRASA2 group were (144.82±24.89), (367.54±65.73), (228.51±40.24), (219.78±36.94) and (324.25±61.57) mg·mL-1, respectively; interleukin-18 levels were (167.50±27.33), (394.68±74.96), (212.47±39.51), (205.93±41.18) and (358.11±66.27) mg·mL-1, respectively; the relative expression levels of Slit2 protein were 1.00±0.18, 2.35±0.41, 1.61±0.29, 1.57±0.27 and 2.14±0.38, respectively; the ratios of phospho-p38 mitogen-activated protein kinase/p38 mitogen-activated protein kinase protein were 1.00±0.16, 2.08±0.37, 1.39±0.25, 1.33±0.21 and 1.92±0.34, respectively. The above indexes in the model group were compared with the control group, the NOB-H group was compared with the model group, and the NOB+oe-circRASA2 group was compared with the NOB+oe-NC group, and the differences were statistically significant (all P<0.05).
Conclusion NOB alleviates LPS-induced inflammation and inhibits pyroptosis in hPDLCs cells by inhibiting circRASA2 expression, possibly by inhibiting Slit2/MAPK signaling pathway.
, authors=Shu-hua LI
1, An-dong LIU
2, authorsList=Shu-hua LI, An-dong LIU, authorCompany=null, correspAuthors=Shu-hua LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404560027865290, articleId=1291404559520354504, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=川陈皮素对脂多糖诱导下牙周膜细胞的抗炎作用与细胞焦亡的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨川陈皮素（NOB）介导环状RNA RAS p21蛋白激活因子2（circRASA2）对脂多糖（LPS）诱导下牙周膜细胞hPDLCs的作用及其机制。
方法 将hPDLCs细胞分为对照组、模型组（hPDLCs细胞以10 μg·mL-1 LPS处理24 h）、NOB-H组（基于模型组，给予20 μmol·L-1 NOB处理24 h）、NOB+oe-NC组（20 μmol·L-1 NOB处理转染oe-NC的模型组hPDLCs细胞）和NOB+oe-circRASA2组（20 μmol·L-1 NOB处理转染oe-circRASA2的模型组hPDLCs细胞）。用实时定量反转录聚合酶链反应法检测circRASA2的相对表达水平，用酶联免疫吸附试验法检测炎症相关因子的分泌水平，用蛋白质印迹法检测SLIT同源物2（Slit2）/丝裂原活化蛋白激酶（MAPK）信号通路相关蛋白相对表达水平。
结果 对照组、模型组和NOB-H组的circRASA2相对表达水平分别为1.00±0.15、2.83±0.50和1.36±0.27。对照组、模型组、NOB-H组、NOB+oe-NC组和NOB+oe-circRASA2组的白细胞介素-1β水平分别为（144.82±24.89）、（367.54±65.73）、（228.51±40.24）、（219.78±36.94）和（324.25±61.57）mg·mL-1，白细胞介素-18水平分别为（167.50±27.33）、（394.68±74.96）、（212.47±39.51）、（205.93±41.18）和（358.11±66.27）mg·mL-1，Slit2蛋白相对表达水平分别为1.00±0.18、2.35±0.41、1.61±0.29、1.57±0.27和2.14±0.38，磷酸化-p38丝裂原活化蛋白激酶/p38丝裂原活化蛋白激酶蛋白比值分别为1.00±0.16、2.08±0.37、1.39±0.25、1.33±0.21和1.92±0.34。模型组的上述指标与对照组比较，NOB-H组的上述指标与模型组比较，NOB+oe-circRASA2组的上述指标与NOB+oe-NC组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 NOB通过抑制circRASA2表达，减轻LPS诱导的hPDLCs细胞炎症水平，抑制细胞焦亡，可能是通过抑制Slit2/MAPK信号通路实现的。
, authors=李淑华
1, 刘安东
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李淑华（1982-），女，副主任医师，主要从事口腔医学方向的相关研究
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